Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Louise Prakash"'
Autor:
Radhika Malik, Robert E. Johnson, Louise Prakash, Satya Prakash, Iban Ubarretxena-Belandia, Aneel K. Aggarwal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-6 (2022)
The structure of mismatched DNA-Polζ ternary complex provides a basis for understanding what makes Polζ adept at extending DNA synthesis past mismatched base pairs.
Externí odkaz:
https://doaj.org/article/f26c65399068427e98751e9f37644e54
Autor:
Olga Rechkoblit, Robert E. Johnson, Yogesh K. Gupta, Louise Prakash, Satya Prakash, Aneel K. Aggarwal
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The human DNA primase and DNA polymerase PrimPol replicates through the major oxidative DNA damage lesion 7,8-dihydro-8-oxoguanine (oxoG) via translesion synthesis in a mostly error-free manner thus suppressing oxoG-induced mutagenesis in mitochondri
Externí odkaz:
https://doaj.org/article/773f625abe814094998cc661e3a4cdba
Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine
Autor:
Olga Rechkoblit, Jayati Roy Choudhury, Angeliki Buku, Louise Prakash, Satya Prakash, Aneel K. Aggarwal
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Cytarabine (AraC) is an essential chemotherapeutic for acute myeloid leukemia (AML) and resistance to this drug is a major cause of treatment failure. AraC is a nucleoside analog that differs from 2′-deoxycytidine only by the presence of a
Externí odkaz:
https://doaj.org/article/fc4ac48cac464dccbd0b27802d40046f
Autor:
Yacob Gómez-Llorente, Radhika Malik, Rinku Jain, Jayati Roy Choudhury, Robert E. Johnson, Louise Prakash, Satya Prakash, Iban Ubarretxena-Belandia, Aneel K. Aggarwal
Publikováno v:
Cell Reports, Vol 5, Iss 1, Pp 79-86 (2013)
DNA polymerase ζ (Polζ) is specialized for the extension step of translesion DNA synthesis (TLS). Despite its central role in maintaining genome integrity, little is known about its overall architecture. Initially identified as a heterodimer of the
Externí odkaz:
https://doaj.org/article/b39f9dfc3c174090be184bc530b8c145
Autor:
Rinku Jain, Kanagalaghatta R Rajashankar, Angeliki Buku, Robert E Johnson, Louise Prakash, Satya Prakash, Aneel K Aggarwal
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94835 (2014)
DNA polymerase ε (Polε) is a multi-subunit polymerase that contributes to genomic stability via its roles in leading strand replication and the repair of damaged DNA. Here we report the ternary structure of the Polε catalytic subunit (Pol2) bound
Externí odkaz:
https://doaj.org/article/bfb805dfd0d24444b60e5287a3ee944c
Publikováno v:
mBio, Vol 3, Iss 5 (2012)
ABSTRACT DNA lesions in the template strand block synthesis by replicative DNA polymerases (Pols). Eukaryotic cells possess a number of specialized translesion synthesis (TLS) Pols with the ability to replicate through DNA lesions. The Epstein-Barr v
Externí odkaz:
https://doaj.org/article/466e71c4c55c4061bc77cbd147b19476
Requirement of Replication Checkpoint Protein Kinases Mec1/Rad53 for Postreplication Repair in Yeast
Publikováno v:
mBio, Vol 2, Iss 3 (2011)
ABSTRACT DNA lesions in the template strand block the replication fork. In Saccharomyces cerevisiae, replication through DNA lesions occurs via a Rad6/Rad18-dependent pathway where lesions can be bypassed by the action of translesion synthesis (TLS)
Externí odkaz:
https://doaj.org/article/66a38f1331a14c769c6d49a653cc48b4
Autor:
Rodrigo Vasquez-Del Carpio, Timothy D Silverstein, Samer Lone, Michael K Swan, Jayati R Choudhury, Robert E Johnson, Satya Prakash, Louise Prakash, Aneel K Aggarwal
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5766 (2009)
BACKGROUND:Oxygen-free radicals formed during normal aerobic cellular metabolism attack bases in DNA and 7,8-dihydro-8-oxoguanine (8-oxoG) is one of the major lesions formed. It is amongst the most mutagenic lesions in cells because of its dual codin
Externí odkaz:
https://doaj.org/article/4b1d6331eec7450fa5120fa3b21c251e
Publikováno v:
J Biol Chem
DNA mismatch repair (MMR) in eukaryotes is believed to occur post-replicatively, wherein nicks or gaps in the nascent DNA strand are suggested to serve as strand discrimination signals. However, how such signals are generated in the nascent leading s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4600130b68fdd01e22c01fc414f8fc
https://europepmc.org/articles/PMC10124943/
https://europepmc.org/articles/PMC10124943/
Autor:
Iban Ubarretxena-Belandia, Mykhailo Kopylov, Louise Prakash, Robert E. Johnson, Radhika Malik, Satya Prakash, Aneel K. Aggarwal, Rinku Jain, Yacob Gomez-Llorente
Publikováno v:
Nature structural & molecular biology
DNA polymerase ζ (Polζ) belongs to the same B-family as high-fidelity replicative polymerases, yet is specialized for the extension reaction in translesion DNA synthesis (TLS). Despite its importance in TLS, the structure of Polζ is unknown. We pr