Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Louise N. Slope"'
Autor:
Stefana Duca, Naa Dei Nikoi, Madeline Berrow, Lois Barber, Louise N. Slope, Anna F.A. Peacock, Felicity de Cogan
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35109- (2024)
Oligoarginine cell-penetrating peptides (CPPs) are short peptides that can enhance drug delivery into cells and are of particular interest in ocular topical formulations for age-related macular degeneration (AMD) treatments. The length and structural
Externí odkaz:
https://doaj.org/article/e19fb43b659b4f8684a91488cf7991d8
Publikováno v:
Angewandte Chemie (International Ed. in English)
Herein we report unprecedented location‐dependent, size‐selective binding to designed lanthanide (Ln3+) sites within miniature protein coiled coil scaffolds. Not only do these engineered sites display unusual Ln3+ selectivity for moderately large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494e6620cc27f32f23a8035a0166bba0
https://doi.org/10.1002/anie.202110500
https://doi.org/10.1002/anie.202110500
Autor:
Louise N. Slope, Jack A. Bryant, Matthew R. Berwick, Naa Dei Nikoi, Anna F. A. Peacock, Lily Riordan, Felicity de Cogan
Publikováno v:
Current Eye Research. 46:751-757
The development of a polyarginine cell-penetrating peptide (CPP) could enable the treatment of age-related macular degeneration, with drugs like bevacizumab, to be administered using eye drops instead of intravitreal injections. Topical formulations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744843fad820791fdddf360bcce44c64
https://doi.org/10.1080/02713683.2020.1830117
https://doi.org/10.1080/02713683.2020.1830117
Autor:
Catherine F. Smith, Melanie M. Britton, Anna F. A. Peacock, Louise N. Slope, Michael G Hill, Felicity de Cogan, Paul Teare
Publikováno v:
Chemical communications (Cambridge, England). 56(26)
The metal hydration state within a designed coiled coil can be progressively tuned across the full integer range (3 → 0 aqua ligands), by careful choice of a second sphere terminal residue, including the lesser used Trp. Potential implications incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6998b0b978b5811a5cfc98561cf1d4b2
https://pubmed.ncbi.nlm.nih.gov/32129331
https://pubmed.ncbi.nlm.nih.gov/32129331
Autor:
Louise N. Slope, Anna F. A. Peacock
Publikováno v:
Chemistry - An Asian Journal. 11:660-666
Bioinorganic chemists aspire to achieve the same exquisite and highly controlled inorganic chemistry featured in biology. An exciting mimetic approach involves the use of miniature artificial protein scaffolds designed de novo (often based on the coi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a61cb86f4637fc39d8fce09a4c75a0
https://doi.org/10.1002/asia.201501173
https://doi.org/10.1002/asia.201501173
Autor:
Melanie M. Britton, Stephen E. Harding, Caitlin F. Smith, Anna F. A. Peacock, Louise N. Slope, Matthew R. Berwick, Arthur J. Rowe, Gary G. Adams, Siobhan M. King, Sarah L. Newton, Richard B. Gillis
Herein, we establish for the first time the design principles for lanthanide coordination within coiled coils, and the important consequences of binding site translation. By interrogating design requirements and by systematically translating binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2420ffccd0115f5404ac3fb313970ce
