Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Louise N. Reynard"'
Publikováno v:
Epigenetics, Vol 15, Iss 6-7, Pp 594-603 (2020)
DNA methylation of CpG sites is commonly measured using Illumina Infinium BeadChip platforms. The Infinium MethylationEPIC array has replaced the Infinium Methylation450K array. The two arrays use the same technology, with the EPIC array assaying alm
Externí odkaz:
https://doaj.org/article/df1f7d28e78143c3a7cc6a6f2d4c6408
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-9 (2019)
Abstract Background Osteoarthritis (OA) is a common disease of older individuals that impacts detrimentally on the quality and the length of life. It is characterised by the painful loss of articular cartilage and is polygenic and multifactorial. Gen
Externí odkaz:
https://doaj.org/article/ffe635fcb70a49d9ad8410ba05cde729
Autor:
Saad Aldalaqan, Caroline Dalgliesh, Sara Luzzi, Chileleko Siachisumo, Louise N Reynard, Ingrid Ehrmann, David J. Elliott
Publikováno v:
Cell Cycle. 21:219-227
High levels of transcription and alternative splicing are recognized hallmarks of gene expression in the testis and largely driven by cells in meiosis. Because of this, the male meiosis stage of the cell cycle is often viewed as having a relatively p
Autor:
Louise N. Reynard, Alexander D. Clark, Arthur G. Pratt, Richard Howey, Najib Naamane, Heather J. Cordell
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 9, p e1009811 (2021)
PLoS Genetics, Vol 17, Iss 9, p e1009811 (2021)
Bayesian networks can be used to identify possible causal relationships between variables based on their conditional dependencies and independencies, which can be particularly useful in complex biological scenarios with many measured variables. Here
Autor:
Arthur G. Pratt, Louise N. Reynard, Ellis Niemantsverdriet, Ben Hargreaves, Nisha Nair, Kieran Murray, Najib Naamane, Anne Barton, Alexander D. Clark, Steve Eyre, Nishanthi Thalayasingam, Annette H M van der Helm-van Mil
Publikováno v:
Rheumatology. 60
Background/Aims Early diagnosis and intervention improves outcomes of immune mediated rheumatic and musculoskeletal diseases (RMDs) but may be hampered by diagnostic uncertainty. The extent to which rationally selected molecular parameters add value
Autor:
Rodolfo Gómez, David Young, Hannah R Elliott, Louise N. Reynard, Andrew J. Skelton, Julia Falk, Matt J. Barter, Kathleen Cheung, Catherine Bui
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-58093-5⟩
Barter, M J, Bui, C, Cheung, K, Falk, J, Gómez, R, Skelton, A J, Elliott, H R, Reynard, L N & Young, D A 2020, ' DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions ', Scientific Reports, vol. 10, 1169 (2020) . https://doi.org/10.1038/s41598-020-58093-5
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-58093-5⟩
Barter, M J, Bui, C, Cheung, K, Falk, J, Gómez, R, Skelton, A J, Elliott, H R, Reynard, L N & Young, D A 2020, ' DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions ', Scientific Reports, vol. 10, 1169 (2020) . https://doi.org/10.1038/s41598-020-58093-5
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Regulation of transcription occurs in a cell type specific manner orchestrated by epigenetic mechanisms including DNA methylation. Methylation changes may also play a key role in lineage specification during stem cell differentiation. To further our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259d354a28bf7d8693992d9cae8e041f
https://hal.univ-lorraine.fr/hal-02949383
https://hal.univ-lorraine.fr/hal-02949383
Autor:
Anne Barton, Arthur G. Pratt, Louise N. Reynard, Julie Diboll, Nisha Nair, Alexander D. Clark, Amy E. Anderson, Andrew J. Skelton, Stephen Eyre, John D. Isaacs, Najib Naamane, Nishanthi Thalayasingam
Publikováno v:
Rheumatology. 59
Background The aetiology of rheumatoid arthritis (RA) is complex. In particular, the vast majority of disease-associated variants implicated by genome-wide association studies are non-coding, leaving genetic mechanisms of adaptive immune dysregulatio
Autor:
Katarzyna A. Piróg, Robert M. Jackson, Tamas Dalmay, Matt J. Barter, Dimitra Tsompani, Sarah Charlton, Andrew J. Skelton, David Young, Kathleen Cheung, Tracey E. Swingler, Jamie Soul, Ian M. Clark, Louise N. Reynard, N. Crowe, Yao Hao, Steven Woods, Colin G. Miles
Publikováno v:
Woods, S, Charlton, S, Cheung, K, Hao, Y, Soul, J, Reynard, L N, Crowe, N, Swingler, T E, Skelton, A J, Piróg, K A, Miles, C G, Tsompani, D, Jackson, R M, Dalmay, T, Clark, I M, Barter, M J & Young, D A 2020, ' microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs ', RNA (New York, N.Y.) . https://doi.org/10.1261/rna.075176.120
RNA
RNA
MiR-140 is selectively expressed in cartilage. Deletion of the entire miR-140 locus in mice results in growth retardation and early-onset osteoarthritis-like pathology, however the relative contribution of miR-140-5p or miR-140-3p to the phenotype re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640a49e1e7871988538477c18d056f34
https://www.research.manchester.ac.uk/portal/en/publications/micrornaseq-of-cartilage-reveals-an-overabundance-of-mir1403p-which-contains-functional-isomirs(25abf5c9-f846-4858-b0ae-09f5d2f6babb).html
https://www.research.manchester.ac.uk/portal/en/publications/micrornaseq-of-cartilage-reveals-an-overabundance-of-mir1403p-which-contains-functional-isomirs(25abf5c9-f846-4858-b0ae-09f5d2f6babb).html
Publikováno v:
Epigenetics
article-version (VoR) Version of Record
article-version (VoR) Version of Record
BackgroundDNA methylation of CpG sites is commonly measured using Illumina Infinium BeadChip platforms. The Infinium MethylationEPIC array has replaced the Infinium Methylation450K array. The two arrays use the same technology, with the EPIC array as
Autor:
Louise N. Reynard
Publikováno v:
Seminars in Cell & Developmental Biology. 62:57-66
Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is complex and highly heritable, with genetic variation estimated to contr