Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Louise N. Paton"'
Autor:
Martina Paumann-Page, Nikolaus F. Kienzl, Jyoti Motwani, Boushra Bathish, Louise N. Paton, Nicholas J. Magon, Benjamin Sevcnikar, Paul G. Furtmüller, Michael W. Traxlmayr, Christian Obinger, Mike R. Eccles, Christine C. Winterbourn
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102090- (2021)
Peroxidasin, a heme peroxidase, has been shown to play a role in cancer progression. mRNA expression has been reported to be upregulated in metastatic melanoma cell lines and connected to the invasive phenotype, but little is known about how peroxida
Externí odkaz:
https://doaj.org/article/ecab46f1afd042139dc822be8320f965
Autor:
Teagan S. Edwards, Nina Dickerhof, Nicholas J. Magon, Louise N. Paton, Peter D. Sly, Anthony J. Kettle
Publikováno v:
The Journal of Immunology. 208:979-990
Calprotectin is released by activated neutrophils along with myeloperoxidase (MPO) and proteases. It plays numerous roles in inflammation and infection, and is used as an inflammatory biomarker. However, calprotectin is readily oxidized by MPO-derive
Autor:
Jyoti Motwani, Martina Paumann-Page, Christian Obinger, Nikolaus F. Kienzl, Christine C. Winterbourn, Louise N. Paton, Michael R. Eccles, Boushra Bathish, Benjamin Sevcnikar, Nicholas J. Magon, Michael W. Traxlmayr, P. G. Furtmueller
Publikováno v:
Redox Biology
Redox Biology, Vol 46, Iss, Pp 102090-(2021)
Redox Biology, Vol 46, Iss, Pp 102090-(2021)
Peroxidasin, a heme peroxidase, has been shown to play a role in cancer progression. mRNA expression has been reported to be upregulated in metastatic melanoma cell lines and connected to the invasive phenotype, but little is known about how peroxida
Autor:
Martina Paumann-Page, Christine C. Winterbourn, Boushra Bathish, Anthony J. Kettle, Louise N. Paton
Publikováno v:
J Biol Chem
Peroxidasin is a heme peroxidase that oxidizes bromide to hypobromous acid (HOBr), a powerful oxidant that promotes the formation of the sulfilimine crosslink in collagen IV in basement membranes. We investigated whether HOBr released by peroxidasin
Publikováno v:
Free radical biologymedicine. 158
Bacillithiol is a major low-molecular-weight thiol in gram-positive firmicutes including the human pathogen Staphylococcus aureus. Bacillithiol is regarded as an important defence mechanism against oxidants produced by the immune system, especially m
Autor:
Christine C. Winterbourn, Marjolein Soethoudt, Markus Bachschmid, Paul E. Pace, Jessica B. Behring, Louise N. Paton, Alexander V. Peskin
Publikováno v:
Journal of Biological Chemistry. 291:3053-3062
Peroxiredoxin 2 (Prx2) is a thiol protein that functions as an antioxidant, regulator of cellular peroxide concentrations, and sensor of redox signals. Its redox cycle is widely accepted to involve oxidation by a peroxide and reduction by thioredoxin
Autor:
Alexander V. Peskin, Louise N. Paton, Paul E. Pace, Marjolein Soethoudt, Christine C. Winterbourn, Nina Dickerhof
Publikováno v:
Free Radical Biology and Medicine. 77:331-339
The diterpenoid, adenanthin, represses tumor growth and prolongs survival in mouse promyelocytic leukemia models (Liu et al., Nat. Chem. Biol. 8, 486, 2012). It was proposed that this was done by inactivating peroxiredoxins (Prxs) 1 and 2 through the
Autor:
Rebecca A. Poynton, Nina Dickerhof, Paul E. Pace, Christine C. Winterbourn, Alexander V. Peskin, Louise N. Paton, Mark B. Hampton
Publikováno v:
Journal of Biological Chemistry. 288:14170-14177
Typical 2-Cys peroxiredoxins (Prxs) react rapidly with H2O2 to form a sulfenic acid, which then condenses with the resolving cysteine of the adjacent Prx in the homodimer or reacts with another H2O2 to become hyperoxidized. Hyperoxidation inactivates
Autor:
Anna-Karin Tidén, Stefan Lundquist, Louisa V. Forbes, Nicholas J. Magon, Guy N. L. Jameson, Henrietta Norman, Staffan Schmidt, Alexandra Bernlind, Françoise Auchère, Susanne Gustavsson, Mats Svensson, Anthony J. Kettle, Revathy Senthilmohan, Per-Olof Markgren, Louise N. Paton, Tove Sjögren, Håkan Eriksson
Publikováno v:
Journal of Biological Chemistry. 286:37578-37589
Myeloperoxidase (MPO) is a prime candidate for promoting oxidative stress during inflammation. This abundant enzyme of neutrophils uses hydrogen peroxide to oxidize chloride to highly reactive and toxic chlorine bleach. We have identified 2-thioxanth
Publikováno v:
Experimental Dermatology. 16:707-714
Three different cell types have been identified in the cortex of wool: orthocortex, mesocortex and paracortex. Fine wool fibres, particularly Merino sheep, are noted for their bilateral distribution of orthocortical and paracortical cells, with the l