Corticotropin‐releasing factor receptor‐1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease

Autor: Louise Monte, Setareh H. Moghadam, Eliezer Masliah, Paul E. Sawchenko, Shannon N. Campbell, Cheng Zhang, Kenner C. Rice, Ching-Chang Kuo, Robert A. Rissman

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 12, iss 5
Zhang, C; Kuo, CC; Moghadam, SH; Monte, L; Campbell, SN; Rice, KC; et al.(2016). Corticotropin-releasing factor receptor-1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease. Alzheimer's and Dementia, 12(5), 527-537. doi: 10.1016/j.jalz.2015.09.007. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/738623k0

© 2016 Alzheimer's Association. Published by Elsevier Inc. All rights reserved. Introduction Stress and corticotropin-releasing factor (CRF) have been implicated as mechanistically involved in Alzheimer's disease (AD), but agents that impact CRF sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903fb7aea599a34662fc0254716cb9e4
https://doi.org/10.1016/j.jalz.2015.09.007

Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606

Autor: Robert A. Rissman, Phuong Nguyen, Weiming Xia, Doo Yeon Kim, Deborah Masliah, Steven K. Duddy, Louise Monte, Ann Becker, Graham Johnson, Jiunn H. Lin, Can Zhang, Kevin D. Rynearson, William C. Mobley, Corinne M. Echmalian, Rudolph E. Tanzi, Steven L. Wagner, Uyen Vo, Justin B. Klee, Luisa Quinti

Publikováno v: The Journal of pharmacology and experimental therapeutics, vol 362, iss 1
The Journal of Pharmacology and Experimental Therapeutics

Alzheimer's disease (AD) is characterized neuropathologically by an abundance of 1) neuritic plaques, which are primarily composed of a fibrillar 42-amino-acid amyloid-β peptide (Aβ), as well as 2) neurofibrillary tangles composed of aggregates of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a46fd75288db093dbde82421751825
https://escholarship.org/uc/item/6n31h1k9

Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport

Autor: April M. Weissmiller, Po Han Lin, Louise Monte, Michelle H. Le, Orlangie Natera, Tia Hexom, Robert A. Rissman, Chengbiao Wu

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0147250 (2016)
PloS one, vol 11, iss 1
PLoS ONE
Le, MH; Weissmiller, AM; Monte, L; Lin, PH; Hexom, TC; Natera, O; et al.(2016). Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport. PLOS ONE, 11(1). doi: 10.1371/journal.pone.0147250. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/15f1873x

Stress exposure or increased levels of corticotropin-releasing factor (CRF) induce hippocampal tau phosphorylation (tau-P) in rodent models, a process that is dependent on the type-1 CRF receptor (CRFR1). Although these preclinical studies on stress-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4617c3c8d70a6d0cb8beebe66ff3f1e6
http://europepmc.org/articles/PMC4720402?pdf=render

Reading between everybody's lines intertextuality in the work of Flannery O'Connor

Autor: Williams, Louise Monte

Publikováno v: Retrospective Theses and Dissertations.

Externí odkaz: https://stars.library.ucf.edu/rtd/1402