Výsledky vyhledávání - "Louise M. Paterson"

Akademický článek

Re-evaluating our focus in addiction: emotional dysregulation is a critical driver of relapse to drug use

Autor: Lexi J. Hand, Louise M. Paterson, Anne R. Lingford-Hughes

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract Most addiction research has focused on reward- and impulsivity-related neurocircuitry. However, the impact of the withdrawal/negative affect stage in the addiction cycle has been somewhat overlooked, despite it being commonly evident in the

Externí odkaz: https://doaj.org/article/525c7d16456a40e1b54f8f5a6ec7f998

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Akademický článek

Exploratory study of associations between monetary reward anticipation brain responses and mu-opioid signalling in alcohol dependence, gambling disorder and healthy controls

Autor: Samuel Turton, Louise M. Paterson, James FM. Myers, Inge Mick, Chen-Chia Lan, John McGonigle, Henrietta Bowden-Jones, Luke Clark, David J. Nutt, Anne R. Lingford-Hughes

Publikováno v: Neuroimage: Reports, Vol 4, Iss 3, Pp 100211- (2024)

Alcohol dependence (AD) and gambling disorder (GD) are common addiction disorders with significant physical and mental health consequences. AD and GD are associated with dysregulated responses to reward which could be due to a common mechanism of dys

Externí odkaz: https://doaj.org/article/0c0ed09750da47048d97c96f3d5a9606

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Akademický článek

Selective D3 receptor antagonism modulates neural response during negative emotional processing in substance dependence

Autor: Ioanna A. Vamvakopoulou, Leon Fonville, Alexandra Hayes, John McGonigle, Rebecca Elliott, Karen D. Ersche, Remy Flechais, Csaba Orban, Anna Murphy, Dana G. Smith, John Suckling, Eleanor M. Taylor, Bill Deakin, Trevor W. Robbins, David J. Nutt, Anne R. Lingford-Hughes, Louise M. Paterson

Publikováno v: Frontiers in Psychiatry, Vol 13 (2022)

IntroductionNegative affective states contribute to the chronic-relapsing nature of addiction. Mesolimbic dopamine D3 receptors are well placed to modulate emotion and are dysregulated in substance dependence. Selective antagonists might restore dopa

Externí odkaz: https://doaj.org/article/4e8eb72042e4416497f16af44766cb8c

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Akademický článek

Disturbances across whole brain networks during reward anticipation in an abstinent addiction population

Autor: Liam J. Nestor, John Suckling, Karen D. Ersche, Anna Murphy, John McGonigle, Csaba Orban, Louise M. Paterson, Laurence Reed, Eleanor Taylor, Remy Flechais, Dana Smith, Edward T. Bullmore, Rebecca Elliott, Bill Deakin, Ilan Rabiner, Anne-Lingford Hughes, Barbara J. Sahakian, Trevor W. Robbins, David J. Nutt

Publikováno v: NeuroImage: Clinical, Vol 27, Iss , Pp 102297- (2020)

The prevalent spatial distribution of abnormalities reported in cognitive fMRI studies in addiction suggests there are extensive disruptions across whole brain networks. Studies using resting state have reported disruptions in network connectivity in

Externí odkaz: https://doaj.org/article/9987c11e6b0d4de496ea949fe410a846

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Akademický článek

The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective

Publikováno v: Frontiers in Psychiatry, Vol 9 (2019)

Alcohol use disorder (AUD) is a brain disorder associated with high rates of mortality and morbidity worldwide. Baclofen, a selective gamma-aminobutyric acid-B (GABA-B) receptor agonist, has emerged as a promising drug for AUD. The use of this drug r

Externí odkaz: https://doaj.org/article/be518acbfc254740b3543c08429da6f2

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Akademický článek

Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures

Autor: Claire F. Durant, Louise M. Paterson, Sam Turton, Susan J. Wilson, James F. M. Myers, Suresh Muthukumaraswamy, Ashwin Venkataraman, Inge Mick, Susan Paterson, Tessa Jones, Limon K. Nahar, Rosa E. Cordero, David J. Nutt, Anne Lingford-Hughes

Publikováno v: Frontiers in Psychiatry, Vol 9 (2018)

Background: The role of GABA-B neurotransmission in addiction has recently received increased attention, with clinical trials indicating that baclofen, a GABA-B receptor agonist, may reduce alcohol consumption, craving and promote abstinence. However

Externí odkaz: https://doaj.org/article/b7a7f1523dd8436cba5c44f089043865

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FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment-a pharmacokinetic-pharmacodynamic study

Autor: Louise M Paterson, Dominic Barker, Suzie Cro, Pavel Mozgunov, Rachel Phillips, Claire Smith, Limon K Nahar, Susan Paterson, Anne R Lingford-Hughes

Background Treatment of opiate addiction with opiate substitution treatment (e.g. methadone) is beneficial. However, some individuals desire or would benefit from abstinence but there are limited options to attenuate problems with opiate withdrawal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6250d3208e0eb42796d27def54252b
https://www.repository.cam.ac.uk/handle/1810/342335

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The neurobiology of substance use and addiction: evidence from neuroimaging and relevance to treatment

Autor: Louise M. Paterson, Anne Lingford-Hughes, Katherine Herlinger, Alexandra Hayes

Publikováno v: BJPsych Advances. 26:367-378

SUMMARYAddiction is a global health problem with a chronic relapsing nature for which there are few treatment options. In the past few decades, neuroimaging has allowed us to better understand the neurobiology of addiction. Functional neuroimaging pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::debbffa989521f6bb5c5247564addea9
https://doi.org/10.1192/bja.2020.68

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A dose-finding design for dual-agent trials with patient-specific doses for one agent with application to an opiate detoxification trial

Autor: Pavel Mozgunov, Suzie Cro, Anne Lingford‐Hughes, Louise M. Paterson, Thomas Jaki

Publikováno v: Pharmaceutical statistics. 21(2)

There is a growing interest in early phase dose-finding clinical trials studying combinations of several treatments. While the majority of dose finding designs for such setting were proposed for oncology trials, the corresponding designs are also ess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7232a0482f9f6f046f2ec72cfc131fb7
https://pubmed.ncbi.nlm.nih.gov/34891221

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Preclinical and clinical aspects of nicotinic acetylcholine receptor imaging

Autor: Patrick J. Riss, Cornelius K. Donat, Peter Brust, Louise M. Paterson, Winnie Deuther-Conrad, Henryk Barthel, Paul Cumming, Alexander Hoepping, Osama Sabri

Publikováno v: RAJO Dierckx et al.: PET and SPECT of Neurobiological Systems, 2nd edition, Heidelberg: Springer, 2021, 978-3-030-53175-1, 593-660
PET and SPECT of Neurobiological Systems ISBN: 9783030531751

Innovations in radiochemistry and pharmacology are opening new vistas for studies of nicotinergic acetylcholine receptors (nAChRs) in human brain by positron emission tomography (PET) and by single-photon emission computed tomography (SPECT). In para

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018b1926bd5d719f14bebba24df1d978
https://www.hzdr.de/publications/Publ-30900-1

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