Výsledky vyhledávání - "Louise Laurell"

Akademický článek

Designing drug occupancy studies with PET neuroimaging: Sample size, occupancy ranges and analytical methods

Autor: Gjertrud Louise Laurell, Pontus Plavén-Sigray, Claus Svarer, R. Todd Ogden, Gitte Moos Knudsen, Martin Schain

Publikováno v: NeuroImage, Vol 263, Iss , Pp 119620- (2022)

Molecular neuroimaging is today considered essential for evaluation of novel CNS drugs; it is used to quantify blood-brain barrier permeability, verify interaction with key target and determine the drug dose resulting in 50% occupancy, IC50. In spite

Externí odkaz: https://doaj.org/article/fb55ae1d3f5f487b9b947c6edd72b463

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Kinetic models for estimating occupancy from single-scan PET displacement studies

Autor: Gjertrud Louise Laurell, Pontus Plavén-Sigray, Annette Johansen, Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Jacob Madsen, Hanne Demant Hansen, Lene Lundgaard Donovan, Gitte Moos Knudsen, Adriaan A Lammertsma, R Todd Ogden, Claus Svarer, Martin Schain

Publikováno v: Laurell, G L, Plavén-Sigray, P, Johansen, A, Raval, N R, Nasser, A, Aabye Madsen, C, Madsen, J, Hansen, H D, Donovan, L L, Knudsen, G M, Lammertsma, A A, Ogden, R T, Svarer, C & Schain, M 2023, ' Kinetic models for estimating occupancy from single-scan PET displacement studies ', Journal of Cerebral Blood Flow and Metabolism . https://doi.org/10.1177/0271678X231168591
Journal of Cerebral Blood Flow and Metabolism. Nature Publishing Group

The traditional design of PET target engagement studies is based on a baseline scan and one or more scans after drug administration. We here evaluate an alternative design in which the drug is administered during an on-going scan (i.e., a displacemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8f95e56fbb9c6f1084263313de0b41
http://www.scopus.com/inward/record.url?scp=85153370411&partnerID=8YFLogxK

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Kinetic models for PET displacement studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c519278d8bfc1442fe153b2b76797c44
https://doi.org/10.1101/2022.11.25.517914

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Children's advocacy centre fails to respond to dental, mental and physical ill-health in abused children

Autor: Linn Göransson, Sofia Ekermann, Christoffer Dovik, Gunilla Klingberg, Karin Ridell, Louise Laurell

Publikováno v: Acta paediatrica (Oslo, Norway : 1992). 111(6)

Aim Sweden´s first multidisciplinary children's advocacy centre (CAC) was founded in 2005 as a collaborative practice between child protection services, the legal system and health care in response to police-reported child abuse. CACs were introduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3080970c237323e0a0734c3c425729a0
https://pubmed.ncbi.nlm.nih.gov/35279867

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[Great need of improved training of paediatricians on children at risk of abuse]

Autor: Ingrid, Almén Uvnäs, Staffan, Janson, Louise, Laurell

Publikováno v: Lakartidningen. 119

In 2009 the Swedish Paediatric Society carried out a national survey that examined the training of paediatric specialty registrars concerning child abuse and neglect. The survey was repeated in 2016. Both surveys highlighted considerable deficits. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a82feee9dd77b39adb515bb5df557102
https://pubmed.ncbi.nlm.nih.gov/35019148

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Comparison of ultrasonography with Doppler and MRI for assessment of disease activity in juvenile idiopathic arthritis: a pilot study

Autor: Marek Zak, Susan Nielsen, Michel Court-Payen, Louise Laurell, Anders Fasth, Mikael Boesen

Publikováno v: Pediatric Rheumatology Online Journal, Vol 10, Iss 1, p 23 (2012)
Pediatric Rheumatology Online Journal
Pediatric Rheumatology; 10(23) (2012)

Background In juvenile idiopathic arthritis (JIA), the trend towards early therapeutic intervention and the development of new highly effective treatments have increased the need for sensitive and specific imaging. Numerous studies have demonstrated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6958bac399f4571ea510dbe742c6d1fa
http://www.ped-rheum.com/content/10/1/23

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Imaging in juvenile idiopathic arthritis with a focus on ultrasonography

Autor: Louise, Laurell, Michel, Court-Payen, Mikael, Boesen, Anders, Fasth

Publikováno v: Clinical and experimental rheumatology. 31(1)

Early therapeutic intervention and use of new highly efficacious treatments have improved the outcome in many patients with juvenile idiopathic arthritis (JIA), but have also led to the need for more precise methods to evaluate disease activity. In a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::abcbdfeeb5189e1ea62ea24c77805abe
https://pubmed.ncbi.nlm.nih.gov/23294536

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A Study of the Use of the Nicaraguan Antenatal Card

Autor: Rodolfo Peña, Per-Olof Östergren, Jerker Liljestrand, Birgitta Essén, Louise Laurell

Publikováno v: Journal of Tropical Pediatrics. 40:133-136

The present study describes the use of a home-based antenatal card in a sample of 120 consecutive women who were giving birth at a large teaching hospital in the city of León, Nicaragua. Information was obtained by interviews with the women before l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887860eeed6dac25d1e18d298d564f17
https://doi.org/10.1093/tropej/40.3.133

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Ultrasonography and color Doppler of proximal gluteal enthesitis in juvenile idiopathic arthritis: a descriptive study

Autor: Carsten Thomsen, Anders Fasth, Susan Nielsen, Michel Court-Payen, Marek Zak, Louise Laurell, Maribel Miguel-Pérez

Publikováno v: Pediatric Rheumatology Online Journal, Vol 9, Iss 1, p 22 (2011)
Pediatric Rheumatology; 9 (2011)
Dipòsit Digital de la UB
Universidad de Barcelona
Pediatric Rheumatology Online Journal
Recercat. Dipósit de la Recerca de Catalunya
instname

Background The presence of enthesitis (insertional inflammation) in patients with juvenile idiopathic arthritis (JIA) is difficult to establish clinically and may influence classification and treatment of the disease. We used ultrasonography (US) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabfea7b24a17e3579c66bab2b89e6c9
http://www.ped-rheum.com/content/9/1/22

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Ultrasonography and color Doppler in juvenile idiopathic arthritis: diagnosis and follow-up of ultrasound-guided steroid injection in the ankle region. A descriptive interventional study

Autor: Louise Laurell, Susan Nielsen, Michel Court-Payen, Anders Fasth, Mikael Boesen, Marek Zak

Publikováno v: Pediatric Rheumatology Online Journal, Vol 9, Iss 1, p 4 (2011)
Pediatric Rheumatology Online Journal
Pediatric Rheumatology; 9(1), no 4 (2011)

Background The ankle region is frequently involved in juvenile idiopathic arthritis (JIA) but difficult to examine clinically due to its anatomical complexity. The aim of the study was to evaluate the role of ultrasonography (US) of the ankle and mid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86435f9a5a971843fed640f0e2dd4766
http://www.ped-rheum.com/content/9/1/4

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