SARS-CoV-2 spike HexaPro formulated in aluminium hydroxide and administered in an accelerated vaccination schedule partially protects Syrian Hamsters against viral challenge despite low neutralizing antibody responses

Autor: Dennis Christensen, Charlotta Polacek, Daniel J. Sheward, Leo Hanke, Gerald McInerney, Ben Murrell, Katrine Top Hartmann, Henrik Elvang Jensen, Julie Zimmermann, Gregers Jungersen, Kristin Engelhart Illigen, Louise Krag Isling, Carlota Fernandez-Antunez, Santseharay Ramirez, Jens Bukh, Gabriel Kristian Pedersen

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

SARS-CoV-2 continues to pose a threat to human health as new variants emerge and thus a diverse vaccine pipeline is needed. We evaluated SARS-CoV-2 HexaPro spike protein formulated in Alhydrogel® (aluminium oxyhydroxide) in Syrian hamsters, using an

Externí odkaz: https://doaj.org/article/12655cec9204492e97cfbf44f7b7e228

Protection against SARS-CoV-2 transmission by a parenteral prime—Intranasal boost vaccine strategy

Autor: Dennis Christensen, Charlotta Polacek, Daniel J. Sheward, Leo Hanke, Ainhoa Moliner-Morro, Gerald McInerney, Ben Murrell, Katrine Top Hartmann, Henrik Elvang Jensen, Gregers Jungersen, Kristin Illigen, Louise Krag Isling, Rune Fledelius Jensen, Julia Sid Hansen, Ida Rosenkrands, Carlota Fernandez-Antunez, Santseharay Ramirez, Frank Follmann, Jens Bukh, Gabriel Kristian Pedersen

Publikováno v: Christensen, D, Polacek, C, Sheward, D J, Hanke, L, Moliner-morro, A, Mcinerney, G, Murrell, B, Hartmann, K T, Jensen, H E, Jungersen, G, Illigen, K, Isling, L K, Jensen, R F, Hansen, J S, Rosenkrands, I, Fernandez-antunez, C, Ramirez, S, Follmann, F, Bukh, J & Pedersen, G K 2022, ' Protection against SARS-CoV-2 transmission by a parenteral prime—Intranasal boost vaccine strategy ', EBioMedicine, vol. 84, 104248 . https://doi.org/10.1016/j.ebiom.2022.104248

BackgroundLicensed vaccines against SARS-CoV-2 effectively protect against severe disease, but display incomplete protection against virus transmission. Mucosal vaccines providing immune responses in the upper airways are one strategy to protect agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2478ec4aa0e62dda8ed072c9896cfd5e
https://curis.ku.dk/portal/da/publications/protection-against-sarscov2-transmission-by-a-parenteral-primeintranasal-boost-vaccine-strategy(a89bca21-8a1d-4c31-b509-47e01826cdbd).html

Late-life effects on rat reproductive system after developmental exposure to mixtures of endocrine disrupters

Autor: Julie Boberg, Sofie Christiansen, Marta Axelstad, Karen Mandrup, Pernille Rosenskjold Jacobsen, Ulla Hass, Andreas Kortenkamp, Louise Krag Isling, Camilla Taxvig, Anne Marie Vinggaard

Publikováno v: REPRODUCTION. 147:465-476

This study examined late-life effects of perinatal exposure of rats to a mixture of endocrine-disrupting contaminants. Four groups of 14 time-mated Wistar rats were exposed by gavage from gestation day 7 to pup day 22 to a mixture of 13 anti-androgen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263429f7f5451bd04a8fbb131f425e44
https://doi.org/10.1530/rep-13-0448

Persistent developmental toxicity in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides

Autor: Julie Boberg, Line Olrik Berthelsen, Anne Marie Vinggaard, Pernille Rosenskjold Jacobsen, Marta Axelstad, Sofie Christiansen, Louise Krag Isling, Ulla Hass, Karen Mandrup

Publikováno v: Reproductive Toxicology. 34:237-250

There is growing concern of permanent damage to the endocrine and nervous systems after developmental exposure to endocrine disrupting chemicals. In this study the permanent reproductive and neurobehavioral effects of combined exposure to five endocr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5cac2eb3dd8496369d9c6a222cc773
https://doi.org/10.1016/j.reprotox.2012.05.099

Epidermolysis bullosa in Danish Hereford calves is caused by a deletion in LAMC2 gene

Autor: Vidhya Jagannathan, Cord Drögemüller, Leonardo Murgiano, Natalie Wiedemar, Louise Krag Isling, Jørgen S. Agerholm

Publikováno v: BMC Veterinary Research
Murgiano, Leonardo; Wiedemar, Natalie; Jagannathan, Vidhya; Isling, Louise K; Drögemüller, Cord; Agerholm, Jørgen S (2015). Epidermolysis bullosa in Danish Hereford calves is caused by a deletion in LAMC2 gene. BMC veterinary research, 11(1), p. 334. BioMed Central 10.1186/s12917-015-0334-8
Murgiano, L, Wiedemar, N, Jagannathan, V, Isling, L K, Drögemüller, C & Agerholm, J S 2015, ' Epidermolysis bullosa in Danish Hereford calves is caused by a deletion in LAMC2 gene ', B M C Veterinary Research, vol. 11, 23 . https://doi.org/10.1186/s12917-015-0334-8

Background Heritable forms of epidermolysis bullosa (EB) constitute a heterogeneous group of skin disorders of genetic aetiology that are characterised by skin and mucous membrane blistering and ulceration in response to even minor trauma. Here we re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f885050f35fef158bddc0c0b92d4c98