Modulation of Cell Death by M. tuberculosis as a Strategy for Pathogen Survival

Autor: Markos Abebe, Louise Kim, Graham Rook, Abraham Aseffa, Liya Wassie, Martha Zewdie, Alimuddin Zumla, Howard Engers, Peter Andersen, T. Mark Doherty

Publikováno v: Clinical and Developmental Immunology, Vol 2011 (2011)

It has been clearly demonstrated that in vitro, virulent M. tuberculosis can favor necrosis over apoptosis in infected macrophages, and this has been suggested as a mechanism for evading the host immune response. We recently reported that an effect c

Externí odkaz: https://doaj.org/article/f59835c3fb28470e9be01361f98c1f28

Autologous Stem Cells in Achilles Tendinopathy (ASCAT): protocol for a phase IIA, single-centre, proof-of-concept study

Autor: Andy Goldberg, Deirdre Brooking, Louise Kim, Razi Zaidi, Lorenzo Masci, Paul O'Donnell, Roger Smith, Michelle Korda, R. Green

Publikováno v: BMJ Open

IntroductionAchilles tendinopathy (AT) is a cause of pain and disability affecting both athletes and sedentary individuals. More than 150 000 people in the UK every year suffer from AT.While there is much preclinical work on the use of stem cells in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c114211fedb08fd9aff6746becc3e61
http://europepmc.org/articles/PMC5961605

Selection of phage-displayed human antibody fragments specific for CD1b presenting the Mycobacterium tuberculosis glycolipid Ac2SGL

Autor: Jim F. Huggett, Armando Acosta, Gennaro De Libero, Louise Kim, Oscar Otero, Lucia Mori, Graham A. W. Rook, Frank Camacho, Mohd Nor Norazmi, Germain Puzo, Fátima Reyes, Martine Gilleron, Maria E. Sarmiento, Marco Lepore

Publikováno v: International Journal of Mycobacteriology
International Journal of Mycobacteriology, 2016, 5 (2), pp.120-127. ⟨10.1016/j.ijmyco.2015.12.002⟩
International Journal of Mycobacteriology, Vol 5, Iss 2, Pp 120-127 (2016)

Objective/background The development of new tools capable of targeting Mycobacterium tuberculosis (Mtb)-infected cells have potential applications in diagnosis, treatment, and prevention of tuberculosis. In Mtb-infected cells, CD1b molecules present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d4acb591a8660ddeeae481a208a280
https://hal.archives-ouvertes.fr/hal-03178062

Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptor

Autor: Brian Gazzard, Pramod K. Srivastava, Justin Stebbing, Robert J. Binder, Louise Kim, Frances Gotch, Mark Bower, Steve Patterson, Sundhiya Mandalia, Simon Portsmouth

Publikováno v: Blood. 102:1806-1814

The most abundant intracellular proteins, heat shock proteins (HSPs), serve as molecular chaperones for regulatory and maturation pathways. Diverse families of HSPs have been shown to bind antigenic peptides and to play major roles in innate and adap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f60c754d0052d752badd185219682c
https://doi.org/10.1182/blood-2003-03-0891

Phage display of functional αβ single-chain T-cell receptor molecules specific for CD1b:Ac₂SGL complexes from Mycobacterium tuberculosis-infected cells

Autor: Frank, Camacho, Jim, Huggett, Louise, Kim, Juan F, Infante, Marco, Lepore, Viviana, Perez, María E, Sarmiento, Graham, Rook, Armando, Acosta

Publikováno v: BMC Immunology

The development of molecules specific for M. tuberculosis-infected cells has important implications, as these tools may facilitate understanding of the mechanisms regulating host pathogen interactions in vivo. In addition, development of new tools ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae41e5900cd27e2c731f51a586ffe2aa
https://pubmed.ncbi.nlm.nih.gov/23458512