Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Louise K. Modis"'
Autor:
Martha Triantafilou, Joshi Ramanjulu, Lee M. Booty, Gisela Jimenez-Duran, Hakan Keles, Ken Saunders, Neysa Nevins, Emma Koppe, Louise K. Modis, G. Scott Pesiridis, John Bertin, Kathy Triantafilou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Evidence exists that the typically antiviral signaling mediator STING is, counterintuitively, needed for optimal human rhinovirus infection. Here the authors confirm this finding and show how human rhinovirus can reduce stored Ca2+ levels to drive th
Externí odkaz:
https://doaj.org/article/59654decd629466e86c28da34c89bb64
Autor:
Gisela Jimenez-Duran, Joseph Kozole, Rachel Peltier-Heap, Eleanor R. Dickinson, Christopher R. Kwiatkowski, Francesca Zappacosta, Roland S. Annan, Nicholas W. Galwey, Eva-Maria Nichols, Louise K. Modis, Martha Triantafilou, Kathy Triantafilou, Lee M. Booty
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The complement system is an ancient and critical part of innate immunity. Recent studies have highlighted novel roles of complement beyond lysis of invading pathogens with implications in regulating the innate immune response, as well as contributing
Externí odkaz:
https://doaj.org/article/18224861a8b0475c8ebbec8ed8c12015
Autor:
Silvia Galván-Peña, Richard G. Carroll, Carla Newman, Elizabeth C. Hinchy, Eva Palsson-McDermott, Elektra K. Robinson, Sergio Covarrubias, Alan Nadin, Andrew M. James, Moritz Haneklaus, Susan Carpenter, Vincent P. Kelly, Michael P. Murphy, Louise K. Modis, Luke A. O’Neill
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Host metabolic reprogramming plays a role in functional responses against pathogens. Here, the authors characterise malonylated proteins in macrophages and show that malonylation of the glycolytic enzyme GAPDH impacts cytokine production by modulatin
Externí odkaz:
https://doaj.org/article/4a15ae022f184e95bae97dad5d2e7a5a
Autor:
Lorna Chernajovsky, Christopher D. Buckley, Luke A. J. O'Neill, Paul P. Tak, Louise K. Modis, Rachel Connor, Elizabeth A. Waterman, Yuti Chernajovsky, David Coutts, Doug Brown
Publikováno v:
Nature Immunology. 22:1344-1348
If new treatments for immune-mediated inflammatory diseases (IMIDs) are to emerge, then a radical new approach that moves the field from one that is based on clinical signs and symptoms to one that is based on immunological and molecular mechanisms i
Autor:
Kevin M.-C. Lee, Christian Ellson, Andrew D. Cook, Maria Feeney, Adrian Achuthan, Andrew J. Fleetwood, John A. Hamilton, Louise K. Modis, Julia Smith, Andrew G. Jarnicki, Gary P. Anderson
Publikováno v:
The Journal of Immunology. 205:213-222
It has been reported that a GM-CSF→CCL17 pathway, originally identified in vitro in macrophage lineage populations, is implicated in the control of inflammatory pain, as well as arthritic pain and disease. We explore, in this study and in various i
Autor:
Eva-Maria Nichols, Kathy Triantafilou, Eleanor Dickinson, Francesca Zappacosta, Roland S. Annan, Lee M. Booty, Louise K. Modis, Christopher Kwiatkowski, Joseph Kozole, Gisela Jimenez-Duran, Nicholas Galwey, Rachel E. Heap, Martha Triantafilou
The complement system is an ancient and critical element of the innate immune system. The terminal step in the complement pathway, the membrane attack complex (MAC), has previously been linked to inflammasome activation and is linked to the pathogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a32efa29276c00b6e76644b5bed4507
https://doi.org/10.21203/rs.3.rs-829685/v1
https://doi.org/10.21203/rs.3.rs-829685/v1
Autor:
Carlos Perez-Sanchez, Ariana Barbera Betancourt, Paul A. Lyons, Zinan Zhang, Chenqu Suo, James C. Lee, Eoin F. McKinney, Louise K. Modis, Christian Ellson, Kenneth G.C. Smith
Publikováno v:
The Journal of experimental medicine. 219(5)
Funder: UK National Institute of Health Research Cambridge Biomedical Research Centre
MicroRNAs are critical regulators of gene expression controlling cellular processes including inflammation. We explored their role in the pathogenesis of infla
MicroRNAs are critical regulators of gene expression controlling cellular processes including inflammation. We explored their role in the pathogenesis of infla
Autor:
Martha Triantafilou, Joshi Ramanjulu, Lee M. Booty, Gisela Jimenez-Duran, Hakan Keles, Ken Saunders, Neysa Nevins, Emma Koppe, Louise K. Modis, G. Scott Pesiridis, John Bertin, Kathy Triantafilou
Publikováno v:
Nature communications. 13(1)
Human rhinovirus (HRV), like coronavirus (HCoV), are positive-strand RNA viruses that cause both upper and lower respiratory tract illness, with their replication facilitated by concentrating RNA-synthesizing machinery in intracellular compartments m
Autor:
Martha Triantafilou, Seth L. Masters, Robert G. Ferris, Louise K. Modis, Magdalena Czubala, Kathy Triantafilou, Christopher J. K. Ward, Emma Koppe, Curt Dale Haffner, Vipulkumar Kantibhai Patel, Heather Amrine-Madsen, Vincent Piguet
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 4, p e1009417 (2021)
PLoS Pathogens, Vol 17, Iss 4, p e1009417 (2021)
Macrophages are important drivers of pathogenesis and progression to AIDS in HIV infection. The virus in the later phases of the infection is often predominantly macrophage-tropic and this tropism contributes to a chronic inflammatory and immune acti
Publikováno v:
Trends in immunology. 41(1)
Memory T cells possess functional differences from naive T cells that powerfully contribute to the efficiency of secondary immune responses. These abilities are imprinted during the primary response, linked to the acquisition of novel patterns of gen