Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Louise K. McCready"'
Autor:
Megan M. Weivoda, Chee Kian Chew, David G. Monroe, Joshua N. Farr, Elizabeth J. Atkinson, Jennifer R. Geske, Brittany Eckhardt, Brianne Thicke, Ming Ruan, Amanda J. Tweed, Louise K. McCready, Robert A. Rizza, Aleksey Matveyenko, Moustapha Kassem, Thomas Levin Andersen, Adrian Vella, Matthew T. Drake, Bart L. Clarke, Merry Jo Oursler, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy s
Externí odkaz:
https://doaj.org/article/801d47b97fd94e109d4d6b51b08d8de3
Autor:
Amanda J Tweed, Shreyasee Amin, Lifeng Yu, Sara J. Achenbach, Elizabeth J. Atkinson, Jad G Sfeir, Jon J. Camp, Sundeep Khosla, Matthew T. Drake, Louise K. McCready, Mark C. Adkins
Publikováno v:
Bone. 112:145-152
Central quantitative computed tomography (QCT) is increasingly used in clinical trials and practice to assess bone mass or strength and to evaluate longitudinal changes in response to drug treatment. Current studies utilize single-energy (SE) QCT sca
Autor:
Brianne S Thicke, Ming Ruan, Aleksey V. Matveyenko, Jennifer R. Geske, Merry Jo Oursler, Amanda J Tweed, David G. Monroe, Bart L. Clarke, Brittany A. Eckhardt, Thomas Levin Andersen, Joshua N. Farr, Chee Kian Chew, Matthew T. Drake, Sundeep Khosla, Adrian Vella, Robert A. Rizza, Elizabeth J. Atkinson, Moustapha Kassem, Louise K. McCready, Megan M. Weivoda
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Weivoda, M M, Chew, C K, Monroe, D G, Farr, J N, Atkinson, E J, Geske, J R, Eckhardt, B, Thicke, B, Ruan, M, Tweed, A J, McCready, L K, Rizza, R A, Matveyenko, A, Kassem, M, Andersen, T L, Vella, A, Drake, M T, Clarke, B L, Oursler, M J & Khosla, S 2020, ' Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism ', Nature Communications, vol. 11, 87 . https://doi.org/10.1038/s41467-019-14003-6
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Weivoda, M M, Chew, C K, Monroe, D G, Farr, J N, Atkinson, E J, Geske, J R, Eckhardt, B, Thicke, B, Ruan, M, Tweed, A J, McCready, L K, Rizza, R A, Matveyenko, A, Kassem, M, Andersen, T L, Vella, A, Drake, M T, Clarke, B L, Oursler, M J & Khosla, S 2020, ' Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism ', Nature Communications, vol. 11, 87 . https://doi.org/10.1038/s41467-019-14003-6
Bone remodeling consists of resorption by osteoclasts followed by formation by osteoblasts, and osteoclasts are a source of bone formation-stimulating factors. Here we utilize osteoclast ablation by denosumab (DMAb) and RNA-sequencing of bone biopsie
Autor:
Koji Fujita, David G. Monroe, Matthew T. Drake, Terry M. Therneau, Matthew M. Roforth, Sundeep Khosla, Elizabeth J. Atkinson, Louise K. McCready, Joshua N. Farr, Julie M. Cunningham
Publikováno v:
Bone. 76:49-57
Age-related bone loss in humans is associated with a decrease in bone formation relative to bone resorption, although the mechanisms for this impairment in bone formation with aging are not well understood. It is known that the precursors for the bon
Autor:
Louise K. McCready, L. Joseph Melton, Joshua N. Farr, Nathan K. LeBrasseur, Elizabeth J. Atkinson, Sundeep Khosla, Shreyasee Amin, Sara J. Achenbach
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 99:4641-4648
Numerous studies have examined the association of body composition with bone development in children and adolescents, but none have used micro-finite element (μFE) analysis of high-resolution peripheral quantitative computed tomography images to ass
Autor:
Shreyasee Amin, L. Joseph Melton, Joshua N. Farr, Salman Kirmani, Sara J. Achenbach, Louise K. McCready, Elizabeth J. Atkinson, Sundeep Khosla
Publikováno v:
Journal of Bone and Mineral Research. 29:2193-2202
Children and adolescents who sustain a distal forearm fracture (DFF) owing to mild, but not moderate, trauma have reduced bone strength and cortical thinning at the distal radius and tibia. Whether these skeletal deficits track into adulthood is unkn
Autor:
Matthew M Drake, Shreyasee Amin, Louise K. McCready, L. Joseph Melton, Joshua N. Farr, Sundeep Khosla
Publikováno v:
Journal of Bone and Mineral Research. 29:787-795
Although patients with type 2 diabetes (T2D) are at significant risk for well-recognized diabetic complications, including macrovascular disease, retinopathy, nephropathy, and neuropathy, it is also clear that T2D patients are at increased risk for f
Autor:
Shreyasee Amin, Salman Kirmani, L. Joseph Melton, Ralph Müller, Elizabeth J. Atkinson, Joshua N. Farr, Louise K. McCready, Sundeep Khosla
Publikováno v:
Journal of Bone and Mineral Research. 29:590-599
Although distal forearm fractures (DFFs) are common during childhood and adolescence, it is unclear whether they reflect underlying skeletal deficits or are simply a consequence of the usual physical activities, and associated trauma, during growth.
Autor:
James M. Peterson, Joshua N. Farr, Louise K. McCready, Elizabeth J. Atkinson, Sundeep Khosla, David G. Monroe, Koji Fujita, Matthew T. Drake, Matthew M. Roforth
Publikováno v:
Osteoporosis International. 25:887-895
We isolate and characterize osteoblasts from humans without in vitro culture. These techniques should be broadly applicable to studying the pathogenesis of osteoporosis and other bone disorders.There is currently no data regarding the expression of s
Autor:
L. Joseph Melton, Shreyasee Amin, B. Lawrence Riggs, Elizabeth J. Atkinson, Sundeep Khosla, Kristy M. Nicks, Louise K. McCready, Klaus Engelke
Publikováno v:
Bone. 55:179-188
Aging is associated with worsening bone structure and increasing risk of hip fracture. However, the commonly used clinical tool, dual-energy x-ray absorptiometry, does not provide information on changes with age or disease separately in trabecular ve