Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Louise K. Hosking"'
Autor:
Paul C. Fletcher, Kay Maltby, Kijoung Song, Karin Mogg, Louise K Hosking, Edward T. Bullmore, Duncan Richards, Mark A. Bush, Brendan P. Bradley, Pradeep J. Nathan, Hisham Ziauddeen, Dawn M. Waterworth, Mauro Zucchetto, Liling Warren, Bhopinder K. Sarai, Chris M. Dodds, Lakshmi Vasist Johnson, Sam R. Miller
Publikováno v:
Journal of Clinical Pharmacology
The mu-opioid system has a key role in hedonic and motivational processes critical to substance addiction. However, existing mu-opioid antagonists have had limited success as anti-addiction treatments. GSK1521498 is a selective and potent mu-opioid a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760d461a33f5de661c4ca8fa2a77b894
https://doi.org/10.1002/jcph.110
https://doi.org/10.1002/jcph.110
Autor:
Liling Warren, Paul C. Fletcher, Louise K Hosking, Chris M. Dodds, Dawn M. Waterworth, Liam J Nestor, Lakshmi Vasist Johnson, Anna Korzeniowska, Duncan Richards, Naresh Subramaniam, Beta Win, Hisham Ziauddeen, Kay Maltby, Disala Fernando, Pradeep J. Nathan, Sam R. Miller, Edward T. Bullmore, Bhopinder K. Sarai
Publikováno v:
Neuropsychopharmacology
The A118G single-nucleotide polymorphism (SNP rs1799971) in the μ-opioid receptor gene, OPRM1, has been much studied in relation to alcohol use disorders. The reported effects of allelic variation at this SNP on alcohol-related behaviors, and on opi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3729718d0350134f7871028e0fa39e65
https://doi.org/10.1038/npp.2017.287
https://doi.org/10.1038/npp.2017.287
Publikováno v:
European Journal of Cancer. 32:2360-2363
In breast cancers and sarcomas, a variant polymorphism in the cell cycle inhibitor P21CIP1/WAF1 is under-represented in those individuals whose tumours contain mutated TP53. The aim of this study was to determine whether this variant polymorphism was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723a748020cf6d8074bd1a6237fa8ed0
https://doi.org/10.1016/s0959-8049(96)00306-1
https://doi.org/10.1016/s0959-8049(96)00306-1
Autor:
Bridget T. Hill, Sharon A. Shellard, Sally L. Davies, Mary K. Danks, Louise K. Hosking, Richard D. H. Whelan, Ian D. Hickson
Publikováno v:
International Journal of Cancer. 57:259-267
Mechanisms of resistance to VP-16 were monitored in a series of sublines of the human testicular teratoma cell line (SuSa) derived following exposure either to fractionated X-irradiation (DXR-10) or to VP-16 using pulsed 24-hr exposures (VP 10) or co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f59ae60b232f3d55c3a2cd846dee2c
https://doi.org/10.1002/ijc.2910570222
https://doi.org/10.1002/ijc.2910570222
Publikováno v:
International Journal of Radiation Biology. 63:765-773
We reported previously that Chinese hamster ovary (CHO) cells surviving exposure to repeated doses of 9 Gy of X-irradiation in vitro expressed a multiple drug resistance phenotype characterized by cross-resistance to epipodophyllotoxins and to Vinca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d16ca2e8ad0a453e78e1fb3218756d9
https://doi.org/10.1080/09553009314552171
https://doi.org/10.1080/09553009314552171
Publikováno v:
Biochemical Pharmacology. 40:1833-1842
Glutathione and its associated enzyme activities have been quantitated in a series of human tumour continuous cell lines expressing a range of in vitro sensitivities to certain antitumour agents. Fourteen different parental lines and 15 various drug-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d0c2fb7ab92d50120de129cf3b4771
https://doi.org/10.1016/0006-2952(90)90364-q
https://doi.org/10.1016/0006-2952(90)90364-q
Autor:
Bridget T. Hill, Louise K. Hosking, P. Bedford, S.A. Shellard, Anne Marie J. Fichtinger-Schepman†
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 19:75-83
In vitro exposure of a human testicular teratoma continuous cell line to fractionated X-irradiation resulted in the expression of resistance to cisplatin. In two independently-derived sublines, designated SUSA-DXR13 and SUSA-DXR10 resulting from trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58da352fa2014cdc40273eba17610663
https://doi.org/10.1016/0360-3016(90)90137-9
https://doi.org/10.1016/0360-3016(90)90137-9
Publikováno v:
JNCI Journal of the National Cancer Institute. 82:607-612
We observed that in vitro exposure of mammalian tumor cells to fractionated x irradiation results in the expression of drug resistance. The cause of this resistance was investigated in a series of Chinese hamster ovary cell lines that had survived ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248a4a311eda6bd906c3d7bc59efb43e
https://doi.org/10.1093/jnci/82.7.607
https://doi.org/10.1093/jnci/82.7.607
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(23)
Single-nucleotide polymorphism (SNP) genotypes were recently examined in an 890-kb region flanking the human gene CYP2D6 . Single-marker and haplotype-based analyses identified, with genomewide significance ( P < 10 -7 ), a 403-kb interval displaying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46034b793d50764a5c021984a99a8f6e
https://pubmed.ncbi.nlm.nih.gov/14597696
https://pubmed.ncbi.nlm.nih.gov/14597696
Publikováno v:
Biochemical pharmacology. 47(5)
Three etoposide-selected resistant sublines of the SuSa testicular teratoma cell line expressing 9-, 21- and 33-fold levels of resistance, proved increasingly cross resistant to cisplatin with levels approximating to 3-, 4- and 6-fold in sublines VPC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76df620c60efa0c6d3fe6ac8ce2c06a2
https://pubmed.ncbi.nlm.nih.gov/8135853
https://pubmed.ncbi.nlm.nih.gov/8135853