Efficacy and safety of eculizumab in children with Shiga-toxin-producing Escherichia coli haemolytic uraemic syndrome: the ECUSTEC RCT

Autor: Natalie Ives, Rebecca Woolley, Moin A Saleem, Catherine A Moakes, Aoife Waters, Rodney D Gilbert, Hugh Jarrett, Elizabeth Brettell, Steve Nash, Louise K Farmer, Khadija Ourradi, Sally A Johnson

Publikováno v: Efficacy and Mechanism Evaluation, Vol 11, Iss 11 (2024)

Background Shiga-toxin-producing Escherichia coli haemolytic uraemic syndrome affects ~100 United Kingdom children each year. Around half need dialysis, a quarter develop serious complications with long-term consequences and ~3% die. No effective int

Externí odkaz: https://doaj.org/article/d211a98eb57e4132bc1c294a564bffab

VEGFC Reduces Glomerular Albumin Permeability and Protects Against Alterations in VEGF Receptor Expression in Diabetic Nephropathy

Autor: David O. Bates, Monica Gamez, Andrew H.J. Salmon, Sara Desideri, Simon C. Satchell, Benjamin P. Dallyn, Siân L. Baker, Raina D. Ramnath, Peter W. Mathieson, Gavin I. Welsh, Louise K. Farmer, Nicola Buckner, Christopher R. Neal, Rebecca R. Foster, Karen L. Onions, Luigi Gnudi, Kai B. Betteridge, Kari Alitalo

Publikováno v: Onions, K L, Gamez, M, Buckner, N R, Baker, S L, Betteridge, K B, Desideri, S, Dallyn, B P, Ramnath, R D, Neal, C R, Farmer, L K, Mathieson, P W, Gnudi, L, Alitalo, K, Bates, D O, Salmon, A H J, Welsh, G I, Satchell, S C & Foster, R R 2019, ' VEGFC reduces glomerular albumin permeability and protects against alterations in VEGF receptor expression in diabetic nephropathy ', Diabetes, vol. 68, no. 1, pp. 172-187 . https://doi.org/10.2337/db18-0045
Onions, K, Gamez, M, Buckner, N R, Baker, S L, Betteridge, K B, Desideri, S, Dallyn, B P, Ramnath, R, Neal, C R, Farmer, L K, Mathieson, P W, Gnudi, L, Alitalo, K, Bates, D O, Salmon, A H J, Welsh, G I, Satchell, S C & Foster, R R 2019, ' VEGFC reduces glomerular albumin permeability and protects against alterations in VEGF receptor expression in diabetic nephropathy ', Diabetes, vol. 68, no. 1, pp. 172-187 . https://doi.org/10.2337/db18-0045

Elevated levels of vascular endothelial growth factor (VEGF) A are thought to cause glomerular endothelial cell (GEnC) dysfunction and albuminuria in diabetic nephropathy. We hypothesized that VEGFC could counteract these effects of VEGFA to protect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c39bf793bc204a86d876d372fe64aec
https://doi.org/10.2337/db18-0045

Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region

Autor: Hong, Huo, Alistair G, Fryatt, Louise K, Farmer, Ralf, Schmid, Richard J, Evans

Publikováno v: The Journal of Biological Chemistry

ATP is the native agonist for cell-surface ligand-gated P2X receptor (P2XR) cation channels. The seven mammalian subunits (P2X1–7) form homo- and heterotrimeric P2XRs having significant physiological and pathophysiological roles. Pyridoxalphosphate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b8799a3a2bbe196c1938574138d8be5
https://pubmed.ncbi.nlm.nih.gov/29997254

The Penultimate Arginine of the Carboxyl Terminus Determines Slow Desensitization in a P2X Receptor from the Cattle Tick Boophilus microplus

Autor: Steven J. Ennion, Volko A. Straub, Louise K. Farmer, Shire K Singh, Felix D Guerrero, Selvan Bavan

Publikováno v: Molecular Pharmacology. 79:776-785

P2X ion channels have been functionally characterized from a range of eukaryotes. Although these receptors can be broadly classified into fast and slow desensitizing, the molecular mechanisms underlying current desensitization are not fully understoo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8602b768aed9753984a0ced07344e0a
https://doi.org/10.1124/mol.110.070037