Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Louise K Farmer"'
Autor:
Natalie Ives, Rebecca Woolley, Moin A Saleem, Catherine A Moakes, Aoife Waters, Rodney D Gilbert, Hugh Jarrett, Elizabeth Brettell, Steve Nash, Louise K Farmer, Khadija Ourradi, Sally A Johnson
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 11, Iss 11 (2024)
Background Shiga-toxin-producing Escherichia coli haemolytic uraemic syndrome affects ~100 United Kingdom children each year. Around half need dialysis, a quarter develop serious complications with long-term consequences and ~3% die. No effective int
Externí odkaz:
https://doaj.org/article/d211a98eb57e4132bc1c294a564bffab
Autor:
Rebecca H. Vaughan, Jean-Claude Kresse, Louise K. Farmer, Marie L. Thézénas, Benedikt M. Kessler, Jan H.N. Lindeman, Edward J. Sharples, Gavin I. Welsh, Rikke Nørregaard, Rutger J. Ploeg, Maria Kaisar
Publikováno v:
American Journal of Transplantation, 22(4), 1073-1087. WILEY
Vaughan, R H, Kresse, J C, Farmer, L K, Thézénas, M L, Kessler, B M, Lindeman, J H N, Sharples, E J, Welsh, G I, Nørregaard, R, Ploeg, R J & Kaisar, M 2022, ' Cytoskeletal protein degradation in brain death donor kidneys associates with adverse posttransplant outcomes ', American Journal of Transplantation, vol. 22, no. 4, pp. 1073-1087 . https://doi.org/10.1111/ajt.16912
Vaughan, R, Kresse, J-C, Farmer, L K, Thézénas, M, Kessler, B, Lindeman, J, Sharples, E, Welsh, G I, Nørregaard, R, Ploeg, R & Kaisar, M 2021, ' Cytoskeletal protein degradation in brain death donor kidneys associates with adverse posttransplant outcomes ', American Journal of Transplantation . https://doi.org/10.1111/ajt.16912
Vaughan, R H, Kresse, J C, Farmer, L K, Thézénas, M L, Kessler, B M, Lindeman, J H N, Sharples, E J, Welsh, G I, Nørregaard, R, Ploeg, R J & Kaisar, M 2022, ' Cytoskeletal protein degradation in brain death donor kidneys associates with adverse posttransplant outcomes ', American Journal of Transplantation, vol. 22, no. 4, pp. 1073-1087 . https://doi.org/10.1111/ajt.16912
Vaughan, R, Kresse, J-C, Farmer, L K, Thézénas, M, Kessler, B, Lindeman, J, Sharples, E, Welsh, G I, Nørregaard, R, Ploeg, R & Kaisar, M 2021, ' Cytoskeletal protein degradation in brain death donor kidneys associates with adverse posttransplant outcomes ', American Journal of Transplantation . https://doi.org/10.1111/ajt.16912
In brain death, cerebral injury contributes to systemic biological dysregulation, causing significant cellular stress in donor kidneys adversely impacting the quality of grafts. Here, we hypothesized that donation after brain death (DBD) kidneys unde
Autor:
David O. Bates, Monica Gamez, Andrew H.J. Salmon, Sara Desideri, Simon C. Satchell, Benjamin P. Dallyn, Siân L. Baker, Raina D. Ramnath, Peter W. Mathieson, Gavin I. Welsh, Louise K. Farmer, Nicola Buckner, Christopher R. Neal, Rebecca R. Foster, Karen L. Onions, Luigi Gnudi, Kai B. Betteridge, Kari Alitalo
Publikováno v:
Onions, K L, Gamez, M, Buckner, N R, Baker, S L, Betteridge, K B, Desideri, S, Dallyn, B P, Ramnath, R D, Neal, C R, Farmer, L K, Mathieson, P W, Gnudi, L, Alitalo, K, Bates, D O, Salmon, A H J, Welsh, G I, Satchell, S C & Foster, R R 2019, ' VEGFC reduces glomerular albumin permeability and protects against alterations in VEGF receptor expression in diabetic nephropathy ', Diabetes, vol. 68, no. 1, pp. 172-187 . https://doi.org/10.2337/db18-0045
Onions, K, Gamez, M, Buckner, N R, Baker, S L, Betteridge, K B, Desideri, S, Dallyn, B P, Ramnath, R, Neal, C R, Farmer, L K, Mathieson, P W, Gnudi, L, Alitalo, K, Bates, D O, Salmon, A H J, Welsh, G I, Satchell, S C & Foster, R R 2019, ' VEGFC reduces glomerular albumin permeability and protects against alterations in VEGF receptor expression in diabetic nephropathy ', Diabetes, vol. 68, no. 1, pp. 172-187 . https://doi.org/10.2337/db18-0045
Onions, K, Gamez, M, Buckner, N R, Baker, S L, Betteridge, K B, Desideri, S, Dallyn, B P, Ramnath, R, Neal, C R, Farmer, L K, Mathieson, P W, Gnudi, L, Alitalo, K, Bates, D O, Salmon, A H J, Welsh, G I, Satchell, S C & Foster, R R 2019, ' VEGFC reduces glomerular albumin permeability and protects against alterations in VEGF receptor expression in diabetic nephropathy ', Diabetes, vol. 68, no. 1, pp. 172-187 . https://doi.org/10.2337/db18-0045
Elevated levels of vascular endothelial growth factor (VEGF) A are thought to cause glomerular endothelial cell (GEnC) dysfunction and albuminuria in diabetic nephropathy. We hypothesized that VEGFC could counteract these effects of VEGFA to protect
Autor:
Ruth Rollason, Shang-Zhong Xu, Lutz Birnbaumer, Daniel J. Whitcomb, Lan Ni, Moin A. Saleem, Louise K. Farmer, Kate J. Heesom, Alexander Goodliff, Abigail C Lay, Gavin I. Welsh
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Journal of the American Society of Nephrology. August 2019:ASN.2018070729
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA
Farmer, L, Rollason, R, Whitcomb, D, Ni, L, Goodlif, A, Lay, A, Birnbaumer, L, Heesom, K, Xu, S-Z, Saleem, M & Welsh, G 2019, ' TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility ', Journal of the American Society of Nephrology, vol. 30, no. 10, pp. 1910-1924 . https://doi.org/10.1681/ASN.2018070729
J Am Soc Nephrol
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Journal of the American Society of Nephrology. August 2019:ASN.2018070729
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA
Farmer, L, Rollason, R, Whitcomb, D, Ni, L, Goodlif, A, Lay, A, Birnbaumer, L, Heesom, K, Xu, S-Z, Saleem, M & Welsh, G 2019, ' TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility ', Journal of the American Society of Nephrology, vol. 30, no. 10, pp. 1910-1924 . https://doi.org/10.1681/ASN.2018070729
J Am Soc Nephrol
Fil: Farmer, Louise K. University of Bristol. Bristol Medical School. Briston Renal; Gran Bretaña Fil: Rollason, Ruth. University of Bristol. Bristol Medical School. Briston Renal; Gran Bretaña Fil: Whitcomb, Daniel J. University of Bristol. Bristo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f4cad1110536e07501e256be5a0c20
https://jasn.asnjournals.org/content/30/10/1910
https://jasn.asnjournals.org/content/30/10/1910
Publikováno v:
The Journal of Biological Chemistry
ATP is the native agonist for cell-surface ligand-gated P2X receptor (P2XR) cation channels. The seven mammalian subunits (P2X1–7) form homo- and heterotrimeric P2XRs having significant physiological and pathophysiological roles. Pyridoxalphosphate
Publikováno v:
The Journal of Biological Chemistry
Background: P2X receptor subtypes show differences in pharmacology. Results: Chimeric P2X receptors exhibit modified partial agonist action and recovery from desensitization. Conclusion: Interactions among the extracellular, transmembrane, and intrac
Autor:
Steven J. Ennion, Volko A. Straub, Louise K. Farmer, Shire K Singh, Felix D Guerrero, Selvan Bavan
Publikováno v:
Molecular Pharmacology. 79:776-785
P2X ion channels have been functionally characterized from a range of eukaryotes. Although these receptors can be broadly classified into fast and slow desensitizing, the molecular mechanisms underlying current desensitization are not fully understoo
Publikováno v:
The Journal of Biological Chemistry
Background: NF449 is a selective P2X1 receptor antagonist. Results: Chimeric/mutant P2X1/4 receptors and molecular docking provided models of NF449 binding. Conclusion: NF449 is coordinated by the core ATP-binding site, the base of the cysteine-rich