Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Louise J. McHeyzer-Williams"'
Autor:
Andrew G. Shuparski, Brett W. Higgins, Karen B. Miller, Chad R. Dufaud, Amanda M. Robinson, Katharina Dueker, Louise J. McHeyzer-Williams, Michael G. McHeyzer-Williams
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101064- (2022)
Summary: Adaptive T and B lymphocytes expand, respond, and persist across a multitude of separable cell differentiation states. Small compartments of these cells present defined cell surface phenotype, but express potentially divergent immune functio
Externí odkaz:
https://doaj.org/article/518966a842d649ecbed2a12ba3e566c3
Autor:
Amanda M. Robinson, Brett W. Higgins, Andrew G. Shuparski, Karen B. Miller, Louise J. McHeyzer-Williams, Michael G. McHeyzer-Williams
Publikováno v:
Sci Immunol
Understanding how follicular helper T cells (TFH) regulate the specialization, maturation, and differentiation of adaptive B cell immunity is crucial for developing durable high-affinity immune protection. Using indexed single-cell molecular strategi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ee52087caad88daeed7c497dd0627a
https://europepmc.org/articles/PMC9881730/
https://europepmc.org/articles/PMC9881730/
Autor:
Brett W. Higgins, Andrew G. Shuparski, Karen B. Miller, Amanda M. Robinson, Louise J. McHeyzer-Williams, Michael G. McHeyzer-Williams
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(25)
Antibodies are produced across multiple isotypes with distinct properties that coordinate initial antigen clearance and confer long-term antigen-specific immune protection. Here, we interrogate the molecular programs of isotype-specific murine plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77514ef99660226ae29342c1efce173b
https://pubmed.ncbi.nlm.nih.gov/35704755
https://pubmed.ncbi.nlm.nih.gov/35704755
Autor:
Karen B. Miller, Andrew G. Shuparski, Brett W. Higgins, Siddhartha M. Sharma, Pierre J. Milpied, Louise J. McHeyzer-Williams, Michael G. McHeyzer-Williams
B cells differentiate into antibody-producing plasma cells (PC) and germinal center (GC) B cells under the guidance of specialized CD4+ follicular helper T (TFH) cells. Here, we demonstrate that CD4 T cells require Prdm1 expression for both early PC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::447eb83afe3b6407722a354ee63b4446
https://doi.org/10.1101/2022.03.31.486642
https://doi.org/10.1101/2022.03.31.486642
Autor:
Andrew G. Shuparski, Brett W. Higgins, Karen B. Miller, Chad R. Dufaud, Amanda M. Robinson, Katharina Dueker, Louise J. McHeyzer-Williams, Michael G. McHeyzer-Williams
Publikováno v:
STAR Protocols
STAR Protocols, Vol 3, Iss 1, Pp 101064-(2022)
STAR Protocols, Vol 3, Iss 1, Pp 101064-(2022)
Summary Adaptive T and B lymphocytes expand, respond, and persist across a multitude of separable cell differentiation states. Small compartments of these cells present defined cell surface phenotype, but express potentially divergent immune function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854afed680993be2bd6d893268311606
http://europepmc.org/articles/PMC8715333
http://europepmc.org/articles/PMC8715333
Autor:
Andrew G Shuparski, Brett W. Higgins, Louise J. McHeyzer-Williams, Michael G. McHeyzer-Williams, Karen B Miller
Multiple CD4 T cell dependent tolerance mechanisms control adaptive B cell immunity to environmental antigens. We recently demonstrated a PD-1 checkpoint within steady-state splenic germinal centers (GC) that constrains the maturation of type 2 IgG1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4ec385cde9a76479ea1edf5d68450aa
https://doi.org/10.1101/2021.09.27.462076
https://doi.org/10.1101/2021.09.27.462076
Autor:
Brett W. Higgins, Louise J. McHeyzer-Williams, Michael G. McHeyzer-Williams, Amanda M Robinson, Andrew G Shuparski, Karen B Miller
Understanding how follicular helper T cells (TFH) regulate the specialization, maturation, and differentiation of adaptive B cell immunity is crucial for developing durable high-affinity immune protection. Using indexed-single cell molecular strategi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59efcdd94cc9a1412fa42eb3340aabae
https://doi.org/10.1101/2021.09.17.460841
https://doi.org/10.1101/2021.09.17.460841
Autor:
Louise J. McHeyzer-Williams, Brett W. Higgins, Amanda M Robinson, Andrew G Shuparski, Karen B Miller, Michael G. McHeyzer-Williams
Antibodies are produced across multiple isotypes with distinct properties that coordinate initial antigen clearance and confer long-term antigen-specific immune protection. Here, we interrogate the molecular programs of isotype-specific murine plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cac5c7e76e31d042b8c00f2839e70772
https://doi.org/10.1101/2021.08.31.458458
https://doi.org/10.1101/2021.08.31.458458
PD-1 checkpoint blockade disrupts CD4 T cell regulated adaptive B cell tolerance to foreign antigens
Autor:
Brett W. Higgins, Michael G. McHeyzer-Williams, Andrew G Shuparski, Chad Dufaud, Louise J. McHeyzer-Williams
SUMMARYAdaptive B cell immunity to environmental antigens must be regulated by multiple CD4 T cell dependent tolerance mechanisms. Using integrated single cell strategies, we demonstrate that acute PD-1 blockade induces extensive and selective local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::784e0c2ffbd9898b65559f0c7bc57644
https://doi.org/10.1101/2021.06.10.447979
https://doi.org/10.1101/2021.06.10.447979
Publikováno v:
Current Opinion in Immunology. 45:112-118
Successful vaccination relies on driving the immune response towards high specificity, affinity and longevity. Germinal centers facilitate the evolution of antigen-specific B cells by iterative rounds of diversification, selection, and differentiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ce36aa913ca13d6f5c1746a3e52d30
https://doi.org/10.1016/j.coi.2017.03.007
https://doi.org/10.1016/j.coi.2017.03.007