Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Louise J Walport"'
Autor:
Jack P.C. Williams, Stephane Mouilleron, Rolando Hernandez Trapero, M. Teresa Bertran, Joseph A. Marsh, Louise J. Walport
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3258-3269 (2024)
Peptidyl arginine deiminase 6 (PADI6 or PAD6) is vital for early embryonic development in mice and humans, yet its function remains elusive. PADI6 is less conserved than other PADIs and it is currently unknown whether it has a catalytic function. Her
Externí odkaz:
https://doaj.org/article/fcbf4234441b46b89675f2fb277a903d
Corrigendum: HPLC for at-line reaction monitoring and purification improves yield and purity of tRNA
Autor:
Polona Megušar, Ewen D. D. Calder, Tina Vodopivec Seravalli, Sergeja Lebar, Louise J. Walport, Rok Sekirnik
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/5162f5b8cb7b4c169967c77223525909
Autor:
Polona Megušar, Ewen D. D. Calder, Tina Vodopivec Seravalli, Sergeja Lebar, Louise J. Walport, Rok Sekirnik
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Engineered transfer RNA is an emerging therapeutic modality, particularly suited to treatment of diseases caused by genetic disorders based on premature termination codons, frameshifts, or missense mutations. It is also extensively used in reprogramm
Externí odkaz:
https://doaj.org/article/779c136fa8384102820cf3811c0f1c73
Autor:
Yuteng Wu, M. Teresa Bertran, Dhira Joshi, Sarah L. Maslen, Catherine Hurd, Louise J. Walport
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-9 (2023)
Abstract Photoaffinity labelling is a promising method for studying protein-ligand interactions. However, obtaining a specific, efficient crosslinker can require significant optimisation. We report a modified mRNA display strategy, photocrosslinking-
Externí odkaz:
https://doaj.org/article/ac80405cd43a480cbf4202f8da9ed517
Autor:
Kuo-Feng Hsu, Sarah E. Wilkins, Richard J. Hopkinson, Rok Sekirnik, Emily Flashman, Akane Kawamura, James S.O. McCullagh, Louise J. Walport, Christopher J. Schofield
Publikováno v:
Epigenetics, Vol 16, Iss 1, Pp 14-27 (2021)
Post-translational modifications (PTMs) to the tails of the core histone proteins are critically involved in epigenetic regulation. Hypoxia affects histone modifications by altering the activities of histone-modifying enzymes and the levels of hypoxi
Externí odkaz:
https://doaj.org/article/232fbe08a0724f6ca2a8f27be76d1d05
Autor:
Akane Kawamura, Martin Münzel, Tatsuya Kojima, Clarence Yapp, Bhaskar Bhushan, Yuki Goto, Anthony Tumber, Takayuki Katoh, Oliver N. F. King, Toby Passioura, Louise J. Walport, Stephanie B. Hatch, Sarah Madden, Susanne Müller, Paul E. Brennan, Rasheduzzaman Chowdhury, Richard J. Hopkinson, Hiroaki Suga, Christopher J. Schofield
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
JmjC histone demethylases (KDMs) are cancer targets due to their links to cell proliferation, but selective inhibition remains a challenge. Here the authors identify potent inhibitors of KDM4A-C—viain vitroselection from a vast library of cyclic pe
Externí odkaz:
https://doaj.org/article/ef8ec2f09725496691198a2fa7af4d88
Autor:
Jason K K Low, Karishma Patel, Paul Solomon, Alexander Norman, Petr Pachl, Natasha Jones, Richard J Payne, Toby Passioura, Hiroaki Suga, Louise J Walport, Joel P Mackay
Bromodomains regulate gene expression by recognizing protein motifs containing acetyllysine. Although originally characterized as histone-binding proteins, it has since become clear that these domains interact with other acetylated proteins, perhaps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27ab2199ddb8297634faec9650223e54
https://doi.org/10.1101/2023.05.17.541126
https://doi.org/10.1101/2023.05.17.541126
Autor:
Louise J. Walport, Richard J. Hopkinson, Rasheduzzaman Chowdhury, Rachel Schiller, Wei Ge, Akane Kawamura, Christopher J. Schofield
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
While reversal of lysine methylation on histone tails is a well-established mechanism to tune gene expression, the existence of a similar arginine demethylation process is controversial. Here, the authors show that some jumonji enzymes possess both l
Externí odkaz:
https://doaj.org/article/b3dc6971dc6349f5a32b481bb23ad534
Autor:
Charlotte Franck, Karishma Patel, Louise J Walport, Mary Christie, Alexander Norman, Toby Passioura, Hiroaki Suga, Richard J Payne, Joel P Mackay
SUMMARYDNA encoded cyclic peptide libraries offer unique opportunities to discover high-potency, high-specificity ligands directed against a target protein. We set out to explore the potential for such libraries to provide ligands that can distinguis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac57072ed90b6678daaf12bce6eb31b6
https://doi.org/10.1101/2022.12.25.521885
https://doi.org/10.1101/2022.12.25.521885
Publikováno v:
Chemical Society Reviews. 50:12292-12307
Protein interactions underlie most molecular events in biology. Many methods have been developed to identify protein partners, to measure the affinity with which these biomolecules interact and to characterise the structures of the complexes. Each ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc5af1a313fd50d4b61cf62e88c33d5
https://doi.org/10.1039/d1cs00548k
https://doi.org/10.1039/d1cs00548k