Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

Autor: Katharina von Loga, Andrew Woolston, Marco Punta, Louise J. Barber, Beatrice Griffiths, Maria Semiannikova, Georgia Spain, Benjamin Challoner, Kerry Fenwick, Ronald Simon, Andreas Marx, Guido Sauter, Stefano Lise, Nik Matthews, Marco Gerlinger

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Tumours that are deficient in mismatch-repair genes should, in theory, have higher evolvability. Here, the authors explore this theory in gastro-oesophageal tumours.

Externí odkaz: https://doaj.org/article/f202e0a95a5045ca81301d8ebb687ecf

CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids

Autor: Reyes Gonzalez-Exposito, Maria Semiannikova, Beatrice Griffiths, Khurum Khan, Louise J. Barber, Andrew Woolston, Georgia Spain, Katharina von Loga, Ben Challoner, Radhika Patel, Michael Ranes, Amanda Swain, Janet Thomas, Annette Bryant, Claire Saffery, Nicos Fotiadis, Sebastian Guettler, David Mansfield, Alan Melcher, Thomas Powles, Sheela Rao, David Watkins, Ian Chau, Nik Matthews, Fredrik Wallberg, Naureen Starling, David Cunningham, Marco Gerlinger

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-14 (2019)

Abstract Background The T cell bispecific antibody cibisatamab (CEA-TCB) binds Carcino-Embryonic Antigen (CEA) on cancer cells and CD3 on T cells, which triggers T cell killing of cancer cell lines expressing moderate to high levels of CEA at the cel

Externí odkaz: https://doaj.org/article/ed3d536126fe414a9681258db65b3503

Data from Efficacy of Chemotherapy in BRCA1/2 Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study

Autor: Stan B. Kaye, Alan Ashworth, Christopher J. Lord, Martin E. Gore, Johann S. de Bono, Lina Chen, James Campbell, Ioannis Assiotis, Kerry Fenwick, Iwanka Kozarewa, Louise J. Barber, Ursula Matulonis, Amit M. Oza, Bella Kaufman, Michael L. Friedlander, Lee-May Chen, Susana Banerjee, Shahneen Sandhu, Timothy A. Yap, Tina Atkinson, Jacques De Greve, Vincent Castonguay, Ronnie Shapira-Frommer, Hilda High, C. Bethan Powell, Charlie Gourley, Joo Ern Ang

Purpose: Preclinical data suggest that exposure to PARP inhibitors (PARPi) may compromise benefit to subsequent chemotherapy, particularly platinum-based regimens, in patients with BRCA1/2 mutation carrier ovarian cancer (PBMCOC), possibly through th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee24a5675257ecabc8bdfc17846d1662
https://doi.org/10.1158/1078-0432.c.6520686.v1

Data from Inhibitors of the Proteasome Suppress Homologous DNA Recombination in Mammalian Cells

Autor: Shunichi Takeda, Simon J. Boulton, Helfrid Hochegger, Guang Yu Zhao, Alan Lehmann, Atsuko Niimi, Hiroshi Kimura, Kyoko Yokomori, Weihua Zeng, Louise J. Barber, Eiichiro Sonoda, Yasuhiro Murakawa

Proteasome inhibitors are novel antitumor agents against multiple myeloma and other malignancies. Despite the increasing clinical application, the molecular basis of their antitumor effect has been poorly understood due to the involvement of the ubiq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582aa01d2fa48fcdcf55ee8e2c21a8b0
https://doi.org/10.1158/0008-5472.c.6496311.v1

Computational Image Analysis of T-Cell Infiltrates in Resectable Gastric Cancer: Association with Survival and Molecular Subtypes

Autor: Maria Semiannikova, Beatrice Griffiths, Alice Newey, Alan Melcher, David Mansfield, Naureen Starling, Marco Gerlinger, Louise J. Barber, Naser Davarzani, Katharina von Loga, Heike I. Grabsch, Nanna Sivamanoharan, Benjamin Challoner, Andrew Woolston, Yuichi Saito, Lindsay C. Hewitt

Publikováno v: Journal of the National Cancer Institute, 113(1), 88-98. Oxford University Press
JNCI Journal of the National Cancer Institute
JNCI: Journal of the National Cancer Institute

Background Gastric and gastro-esophageal junction cancers (GCs) frequently recur after resection, but markers to predict recurrence risk are missing. T-cell infiltrates have been validated as prognostic markers in other cancer types, but not in GC be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a484e10998a482fedbfe2a0d3158e9d9
https://doi.org/10.1093/jnci/djaa051