Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Louise Hedskog"'
Autor:
Helena Karlström, Lena Lilius, Louise Hedskog, Birgitta Wiehager, Catarina Moreira Pinho, Elzbieta Glaser, Caroline Graff, Maria Ankarcrona, Jesper Brohede, Priya Revathikumar
Publikováno v:
Journal of Alzheimer's Disease. 31:527-536
The apolipoprotein E (APOE) gene remains the most strongly established risk factor for late onset Alzheimer's disease (LOAD). Recently the gene, TOMM40, which is in linkage disequilibrium with APOE, was identified to be associated with LOAD in genome
Publikováno v:
Antioxidants & Redox Signaling. 16:1476-1491
Detailed knowledge about cell death and cell survival mechanisms and how these pathways are impaired in neurodegenerative disorders and cancer forms the basis for future drug development for these diseases that affect millions of people around the wo
γ-secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ42/Aβ40 ratio
Autor:
Lars O. Tjernberg, Louise Hedskog, Helena Karlström, Anne-Lie Svensson, Hedvig Welander, Maria Ankarcrona, Camilla A. Hansson Petersen
Publikováno v:
Journal of Cellular and Molecular Medicine
Markers for caspase activation and apoptosis have been shown in brains of Alzheimer's disease (AD) patients and AD-mouse models. In neurons, caspase activation is associated with elevated amyloid β-peptide (Aβ) production. Caspases cleave numerous
Publikováno v:
Journal of Alzheimer's disease : JAD. 43(2)
Extracellular aggregates of amyloid-β peptides (Aβ) are a hallmark in Alzheimer's disease (AD) brains. Recent findings suggest that Aβ is generated intracellularly and potential production sites include endosomes and trans-Golgi network. We determ
Autor:
Catarina Moreira Pinho, Elzbieta Glaser, Pia Larssen, Annica Rönnbäck, Sandra Gellhaar, Anna Sandebring, Riccardo Filadi, Marie Westerlund, Paola Pizzo, Caroline Graff, Dagmar Galter, Bengt Winblad, Maria Ankarcrona, Homira Behbahani, Louise Hedskog, Birgitta Wiehager, Laura Hertwig
It is well-established that subcompartments of endoplasmic reticulum (ER) are in physical contact with the mitochondria. These lipid raft-like regions of ER are referred to as mitochondria-associated ER membranes (MAMs), and they play an important ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026f92a9d25e17e4ef92d7a1cfd28e72
https://europepmc.org/articles/PMC3651455/
https://europepmc.org/articles/PMC3651455/
Autor:
Annica Rönnbäck, Louise Hedskog, Dagmar Galter, Birgitta Wiehager, Laura Hertwig, Anna Sandebring, Mimi Marie Westerlund, Maria Ankarcrona, Catarina Moreira Pinho, Elzbieta Glaser, Homira Behbahani
Publikováno v:
Alzheimer's & Dementia. 8
Publikováno v:
Journal of Alzheimer's disease : JAD. 21(2)
Dimebon, a drug currently being evaluated in multiple Phase III Alzheimer's disease trials, has previously been shown to have effects on isolated mitochondria at muM concentrations. Here the effects of nM concentrations of Dimebon on mitochondrial fu
Publikováno v:
Alzheimer's & Dementia. 4