Zobrazeno 1 - 10 of 46 pro vyhledávání: '"Louise H. Boyle"'
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Akademický článek
Distinct Polymorphisms in HLA Class I Molecules Govern Their Susceptibility to Peptide Editing by TAPBPR
Autor: F. Tudor Ilca, Linnea Z. Drexhage, Gemma Brewin, Sarah Peacock, Louise H. Boyle
Publikováno v: Cell Reports, Vol 29, Iss 6, Pp 1621-1632.e3 (2019)
Summary: Understanding how peptide selection is controlled on different major histocompatibility complex class I (MHC I) molecules is pivotal for determining how variations in these proteins influence our predisposition to infectious diseases, cancer
Externí odkaz: https://doaj.org/article/eca1794479964c7690a001cdde7da6d6
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3
Akademický článek
Reanalysis of Immunopeptidomics Datasets Provides Mechanistic Insight into TAPBPR-Mediated Peptide Editing on HLA-A, -B and -C Molecules [version 1; peer review: 1 approved, 2 approved with reservations]
Autor: Jack L Morley, Arwen F Altenburg, Juliane S Walz, Jens Bauer, Louise H Boyle
Publikováno v: Wellcome Open Research, Vol 9 (2024)
Background Major histocompatibility class I (MHC-I, human leukocyte antigen [HLA]-I in humans) molecules present small fragments of the proteome on the cell surface for immunosurveillance, which is pivotal to control infected and malignant cells. Imm
Externí odkaz: https://doaj.org/article/ab62c45160514459b941413a277bb80b
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6
Why TAPBPR? Implications of an additional player in MHC class I peptide presentation
Autor: Louise H. Boyle, Ida Hafstrand, Aure Aflalo
Publikováno v: Current Opinion in Immunology. 70:90-94
The peptide editor TAPBPR is the newest member of the major histocompatibility complex class I (MHC-I) antigen processing and presentation pathway. Since 2013, studies have explored the functions and mechanisms of action of this tapasin homolog. Here
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d351142b20c232ccbccda1f2be3754fa
https://doi.org/10.1016/j.coi.2021.04.011
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9
Polymorphisms in MHC class I molecules influence their interactions with components of the antigen processing and presentation pathway
Autor: Louise H. Boyle, Aure Aflalo
MHC class I (MHC-I) molecules undergo an intricate folding process in order to pick up antigenic peptide to present to the immune system. In recent years, the discovery of a new peptide editor for MHC-I has added an extra level of complexity in our u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee117ae6c4204bd647abb06557b5dae
https://www.repository.cam.ac.uk/handle/1810/323234
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10
The glycosylation status of MHC class I molecules impacts their interactions with TAPBPR
Autor: Louise H. Boyle, F. Tudor Ilca
Publikováno v: Molecular Immunology
Highlights • The interaction between TAPBPR and MHC-I is stronger when MHC-I lacks a glycan. • TAPBPR dissociates peptides more easily from non-glycosylated MHC-I. • Glycosylation status of MHC-I influences their ability to undergo peptide exch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c730f7419cfa8f1bde6dc39004598db
https://pubmed.ncbi.nlm.nih.gov/34543843
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