Zobrazeno 1 - 10 of 63 pro vyhledávání: '"Louise H. Boyle"'
1
Akademický článek
Reanalysis of Immunopeptidomics Datasets Provides Mechanistic Insight into TAPBPR-Mediated Peptide Editing on HLA-A, -B and -C Molecules [version 1; peer review: 1 approved, 2 approved with reservations]
Autor: Jack L Morley, Arwen F Altenburg, Juliane S Walz, Jens Bauer, Louise H Boyle
Publikováno v: Wellcome Open Research, Vol 9 (2024)
Background Major histocompatibility class I (MHC-I, human leukocyte antigen [HLA]-I in humans) molecules present small fragments of the proteome on the cell surface for immunosurveillance, which is pivotal to control infected and malignant cells. Imm
Externí odkaz: https://doaj.org/article/ab62c45160514459b941413a277bb80b
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2
Akademický článek
Distinct Polymorphisms in HLA Class I Molecules Govern Their Susceptibility to Peptide Editing by TAPBPR
Autor: F. Tudor Ilca, Linnea Z. Drexhage, Gemma Brewin, Sarah Peacock, Louise H. Boyle
Publikováno v: Cell Reports, Vol 29, Iss 6, Pp 1621-1632.e3 (2019)
Summary: Understanding how peptide selection is controlled on different major histocompatibility complex class I (MHC I) molecules is pivotal for determining how variations in these proteins influence our predisposition to infectious diseases, cancer
Externí odkaz: https://doaj.org/article/eca1794479964c7690a001cdde7da6d6
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3
Akademický článek
TAPBPR mediates peptide dissociation from MHC class I using a leucine lever
Autor: F Tudor Ilca, Andreas Neerincx, Clemens Hermann, Ana Marcu, Stefan Stevanović, Janet E Deane, Louise H Boyle
Publikováno v: eLife, Vol 7 (2018)
Tapasin and TAPBPR are known to perform peptide editing on major histocompatibility complex class I (MHC I) molecules; however, the precise molecular mechanism(s) involved in this process remain largely enigmatic. Here, using immunopeptidomics in com
Externí odkaz: https://doaj.org/article/d267f215987a4db2b173a8b9f985aef6
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6
Why TAPBPR? Implications of an additional player in MHC class I peptide presentation
Autor: Louise H. Boyle, Ida Hafstrand, Aure Aflalo
Publikováno v: Current Opinion in Immunology. 70:90-94
The peptide editor TAPBPR is the newest member of the major histocompatibility complex class I (MHC-I) antigen processing and presentation pathway. Since 2013, studies have explored the functions and mechanisms of action of this tapasin homolog. Here
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d351142b20c232ccbccda1f2be3754fa
https://doi.org/10.1016/j.coi.2021.04.011
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7
Akademický článek
TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway
Autor: Andreas Neerincx, Clemens Hermann, Robin Antrobus, Andy van Hateren, Huan Cao, Nico Trautwein, Stefan Stevanović, Tim Elliott, Janet E Deane, Louise H Boyle
Publikováno v: eLife, Vol 6 (2017)
Recently, we revealed that TAPBPR is a peptide exchange catalyst that is important for optimal peptide selection by MHC class I molecules. Here, we asked whether any other co-factors associate with TAPBPR, which would explain its effect on peptide se
Externí odkaz: https://doaj.org/article/c132d87a727842aba0f630db881afb89
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9
Akademický článek
TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst
Autor: Clemens Hermann, Andy van Hateren, Nico Trautwein, Andreas Neerincx, Patrick J Duriez, Stefan Stevanović, John Trowsdale, Janet E Deane, Tim Elliott, Louise H Boyle
Publikováno v: eLife, Vol 4 (2015)
Our understanding of the antigen presentation pathway has recently been enhanced with the identification that the tapasin-related protein TAPBPR is a second major histocompatibility complex (MHC) class I-specific chaperone. We sought to determine whe
Externí odkaz: https://doaj.org/article/ada3abf3139b4cf88664e56269726921
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