Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Louise H W Kung"'
Autor:
Louise H. W. Kung, Lorna Mullan, Jamie Soul, Ping Wang, Kazutoshi Mori, John F. Bateman, Michael D. Briggs, Raymond P. Boot-Handford
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-13 (2019)
Abstract Background Osteoarthritis has been associated with a plethora of pathological factors and one which has recently emerged is chondrocyte endoplasmic reticulum (ER) stress. ER stress is sensed by key ER-resident stress sensors, one of which is
Externí odkaz:
https://doaj.org/article/a4f7bbd62ff44cc7942e5f91d11de813
Autor:
Shireen R. Lamandé, Elizabeth S. Ng, Trevor L. Cameron, Louise H. W. Kung, Lisa Sampurno, Lynn Rowley, Jinia Lilianty, Yudha Nur Patria, Tayla Stenta, Eric Hanssen, Katrina M. Bell, Ritika Saxena, Kathryn S. Stok, Edouard G. Stanley, Andrew G. Elefanty, John F. Bateman
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Chondrocytes and osteoblasts differentiated from induced pluripotent stem cells (iPSCs) will provide insights into skeletal development and genetic skeletal disorders and will generate cells for regenerative medicine applications. Here, we describe a
Autor:
Martha Blank, Narelle E. McGregor, Lynn Rowley, Louise H. W. Kung, Blessing Crimeen‐Irwin, Ingrid J. Poulton, Emma C. Walker, Jonathan H. Gooi, Shireen R. Lamandé, Natalie A. Sims, John F. Bateman
Publikováno v:
Journal of Cellular and Molecular Medicine. 26:4021-4031
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117016 (2015)
Mutations in genes encoding cartilage oligomeric matrix protein and matrilin-3 cause a spectrum of chondrodysplasias called multiple epiphyseal dysplasia (MED) and pseudoachondroplasia (PSACH). The majority of these diseases feature classical endopla
Externí odkaz:
https://doaj.org/article/dd5c17f983e44dffa4ba9f6b5e564e6c
Publikováno v:
Stem Cell Research, Vol 50, Iss, Pp 102118-(2021)
miR-26b has been implicated in a wide range of human diseases, including cancer, diabetes, heart disease, Alzheimer’s disease and osteoarthritis. To provide a tool to explore the importance of miR-26b in this broad context, we have generated and ch
Autor:
Kathryn M. Yammine, John F. Bateman, Penny McDonald, Matthew D. Shoulders, Alison Graham, Lisa Sampurno, Shireen R. Lamandé, Louise H. W. Kung
Publikováno v:
Stem Cell Research, Vol 48, Iss, Pp 101962-(2020)
To develop an in vitro disease model of a human chondrodysplasia, we used CRISPR/Cas9 gene editing to generate a heterozygous COL2A1 exon 50 c.3508 GGT > TCA (p.G1170S) mutation in a control human iPSC line. Both the control and COL2A1 mutant lines d
Autor:
John F. Bateman, Varshini Ravi, Louise H. W. Kung, Lynn Rowley, Katrina M. Bell, Christopher B. Little
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
To better understand the molecular processes involved in driving osteoarthritis disease progression we characterized expression profiles of microRNAs (miRNA) and mRNAs in synovial tissue from a post-traumatic OA mouse model. OA was induced in 10–12
Autor:
Sanaa Zaki, Margaret M. Smith, John F. Bateman, Katrina M. Bell, L. Rowley, Louise H. W. Kung, Christopher B. Little, Varshini Ravi
Publikováno v:
Osteoarthritis and Cartilage. 25:426-434
Summary Objective The purpose of this study was to determine if serum microRNA (miRNA) signatures were biomarkers of early cartilage degeneration in preclinical mouse models of post-traumatic osteoarthritis (OA) and inflammatory arthritis. Methods Ca
Autor:
John F. Bateman, Christopher B. Little, V. Ravi, Amanda J. Fosang, Constanza Angelucci, Louise H. W. Kung, Lynn Rowley, Katrina M. Bell
To explore the role of microRNAs in osteoarthritis (OA), we conducted microRNA expression profiling on micro-dissected tibial cartilage and subchondral bone in a mouse model of OA produced by medial meniscus destabilization (DMM). DMM mice had charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a98832b1bbd0b9c0f0aa37db8e52b1
https://doi.org/10.1101/113456
https://doi.org/10.1101/113456
Publikováno v:
Journal of Histochemistry and Cytochemistry
Mutations causing metaphyseal chondrodysplasia type Schmid (MCDS) (e.g., Col10a1p.N617K) induce the pathology by a mechanism involving increased endoplasmic reticulum (ER) stress triggering an unfolded protein response (UPR) in hypertrophic chondrocy