Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Louise Ford"'
Autor:
Rachel H. Clare, Catherine Bardelle, Paul Harper, W. David Hong, Ulf Börjesson, Kelly L. Johnston, Matthew Collier, Laura Myhill, Andrew Cassidy, Darren Plant, Helen Plant, Roger Clark, Darren A. N. Cook, Andrew Steven, John Archer, Paul McGillan, Sitthivut Charoensutthivarakul, Jaclyn Bibby, Raman Sharma, Gemma L. Nixon, Barton E. Slatko, Lindsey Cantin, Bo Wu, Joseph Turner, Louise Ford, Kirsty Rich, Mark Wigglesworth, Neil G. Berry, Paul M. O’Neill, Mark J. Taylor, Stephen A. Ward
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Parasitic nematodes causing onchocerciasis and lymphatic filariasis rely on a bacterial endosymbiont, Wolbachia, which is a validated therapeutic target. Here, Clare et al. perform a high-throughput screen of 1.3 million compounds and identify 5 chem
Externí odkaz:
https://doaj.org/article/4cb4bba947a8460babf1f27b9cb22a73
Autor:
Ghaith Aljayyoussi, Hayley E. Tyrer, Louise Ford, Hanna Sjoberg, Nicolas Pionnier, David Waterhouse, Jill Davies, Joanne Gamble, Haelly Metuge, Darren A. N. Cook, Andrew Steven, Raman Sharma, Ana F. Guimaraes, Rachel H. Clare, Andrew Cassidy, Kelly L. Johnston, Laura Myhill, Laura Hayward, Samuel Wanji, Joseph D. Turner, Mark J. Taylor, Stephen A. Ward
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Lymphatic filariasis (LF) and onchocerciasis are priority neglected tropical diseases targeted for elimination. The only safe drug treatment with substantial curative activity against the filarial nematodes responsible for LF (Brugia malayi,
Externí odkaz:
https://doaj.org/article/5458446623e84d6f9b626f860c2cd9e3
Autor:
Thomas W von Geldern, Howard E Morton, Rick F Clark, Brian S Brown, Kelly L Johnston, Louise Ford, Sabine Specht, Robert A Carr, Deanne F Stolarik, Junli Ma, Matthew J Rieser, Dominique Struever, Stefan J Frohberger, Marianne Koschel, Alexandra Ehrens, Joseph D Turner, Marc P Hübner, Achim Hoerauf, Mark J Taylor, Stephen A Ward, Kennan Marsh, Dale J Kempf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007159 (2019)
There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide) would be expected to substanti
Externí odkaz:
https://doaj.org/article/68bed1add1a349b9b6bff6345f18be14
Autor:
Sabine Specht, Kenneth M Pfarr, Sandra Arriens, Marc P Hübner, Ute Klarmann-Schulz, Marianne Koschel, Sonja Sternberg, Coralie Martin, Louise Ford, Mark J Taylor, Achim Hoerauf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006116 (2018)
Filarial parasites can be targeted by antibiotic treatment due to their unique endosymbiotic relationship with Wolbachia bacteria. This finding has led to successful treatment strategies in both, human onchocerciasis and lymphatic filariasis. A 4-6 w
Externí odkaz:
https://doaj.org/article/6980e7b8ae6245a286ea69f8f6cf2598
Autor:
Kelly L. Johnston, Louise Ford, Indira Umareddy, Simon Townson, Sabine Specht, Kenneth Pfarr, Achim Hoerauf, Ralf Altmeyer, Mark J. Taylor
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 4, Iss 3, Pp 278-286 (2014)
Lymphatic filariasis and onchocerciasis are debilitating diseases caused by parasitic filarial nematodes infecting around 150 million people throughout the tropics with more than 1.5 billion at risk. As with other neglected tropical diseases, classic
Externí odkaz:
https://doaj.org/article/191f48b845eb4d168c6bc523ea0cd3ab
Autor:
Ute Klarmann-Schulz, Sabine Specht, Alexander Yaw Debrah, Linda Batsa, Nana Kwame Ayisi-Boateng, Jubin Osei-Mensah, Yusif Mubarik, Peter Konadu, Arcangelo Ricchiuto, Rolf Fimmers, Sandra Arriens, Bettina Dubben, Louise Ford, Mark Taylor, Achim Hoerauf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 1, p e0005156 (2017)
The search for new macrofilaricidal drugs against onchocerciasis that can be administered in shorter regimens than required for doxycycline (DOX, 200mg/d given for 4-6 weeks), identified minocycline (MIN) with superior efficacy to DOX. Further reduct
Externí odkaz:
https://doaj.org/article/7e05df65a5f2493cba57b00fb500101a
Autor:
Denis Voronin, Ana F Guimarães, Gemma R Molyneux, Kelly L Johnston, Louise Ford, Mark J Taylor
Publikováno v:
Parasites & Vectors, Vol 7, Iss 1, Pp 1-10 (2014)
Abstract Background Lipoproteins are the major agonists of Wolbachia-dependent inflammatory pathogenesis in filariasis and a validated target for drug discovery. Here we characterise the abundance, localisation and serology of the Wolbachia lipoprote
Externí odkaz:
https://doaj.org/article/21a33ac83dc347d79dbef05a08e3d713
Autor:
Jeremy M Foster, Frédéric Landmann, Louise Ford, Kelly L Johnston, Sarah C Elsasser, Albrecht I Schulte-Hostedde, Mark J Taylor, Barton E Slatko
Publikováno v:
Parasites & Vectors, Vol 7, Iss 1, Pp 1-5 (2014)
Abstract Background Wolbachia endosymbionts are a proven target for control of human disease caused by filarial nematodes. However, little is known about the occurrence of Wolbachia in taxa closely related to the superfamily Filarioidea. Our study ad
Externí odkaz:
https://doaj.org/article/a4306c9524d44cf2ab68b32c09af3c92
Autor:
Ghaith Aljayyoussi, Hayley E. Tyrer, Louise Ford, Hanna Sjoberg, Nicolas Pionnier, David Waterhouse, Jill Davies, Joanne Gamble, Haelly Metuge, Darren A. N. Cook, Andrew Steven, Raman Sharma, Ana F. Guimaraes, Rachel H. Clare, Andrew Cassidy, Kelly L. Johnston, Laura Myhill, Laura Hayward, Samuel Wanji, Joseph D. Turner, Mark J. Taylor, Stephen A. Ward
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
Externí odkaz:
https://doaj.org/article/e385b0ad0b0a47df831e0a685925f5a2
Autor:
Jan-Hendrik Schroeder, Bigboy H Simbi, Louise Ford, Sara R Cole, Mark J Taylor, Charlotte Lawson, Rachel A Lawrence
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 11, p e1914 (2012)
Lymphatic filariasis is a major tropical disease caused by the parasite Brugia malayi. Microfilariae (Mf) circulate in the peripheral blood for 2-3 hours in synchronisation with maximal feeding of the mosquito vector. When absent from the peripheral
Externí odkaz:
https://doaj.org/article/25b7ac93d4934b2d87308fba184bb421