Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Louise F.B. Nicholson"'
Publikováno v:
F1000Research, Vol 5 (2016)
Systemic inflammation is associated with neurodegeneration, with elevated interleukin-6 (IL-6) in particular being correlated with an increased risk of dementia. The brain endothelial cells of the blood brain barrier (BBB) serve as the interface betw
Externí odkaz:
https://doaj.org/article/66bd7c1de5f04c589d6bc912da4c4190
Autor:
Joo Hyun Kim, Dian Shi, Joshua W. Chang, Louise F.B. Nicholson, Simon J. O'Carroll, Jai Min Choi, Bronwen Connor
Publikováno v:
Neuroscience. 380:146-151
Receptor for advanced glycation end products (RAGE) is a multi-ligand receptor involved in the pathology of several progressive neurodegenerative disorders including Huntington's disease (HD). We previously showed that the expression of RAGE and its
Autor:
Yeri Kim, Colin R. Green, Simon J. O'Carroll, Joanne O. Davidson, Jie Zhang, Louise F.B. Nicholson
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1860:224-236
A common cause of mortality and long-term adult disability, cerebral ischemia or brain ischemia imposes a significant health and financial burden on communities worldwide. Cerebral ischemia is a condition that arises from a sudden loss of blood flow
Autor:
Catherine A. Gorrie, Tara Nguyen, Colin R. Green, Simon J. O'Carroll, Ryan S. Tonkin, Yilin Mao, Louise F.B. Nicholson, Gila Moalem-Taylor
Publikováno v:
Journal of Neurotrauma. 34:707-719
© Mary Ann Liebert, Inc. 2017. Blocking of Connexin43 hemichannels, the main gap junction protein located on astrocytes in the central nervous system, has been shown to reduce neural injury in a number of models. We demonstrated previously that loca
Autor:
Laverne D Robilliard, E Scott Graham, Simon J. O'Carroll, Louise F.B. Nicholson, Odunayo O Mugisho
Publikováno v:
Cell biology international.
Neuroinflammatory disorders such as Alzheimer's and Parkinson's diseases are characterised by chronic inflammation and loss of vascular integrity. Bradykinin 1 receptor (B1R) activation has been implicated in many neuroinflammatory diseases, but the
Publikováno v:
The Neuroscientist. 23:7-15
Engaging young people with science is essential to ensuring a scientifically literate society. Furthermore, it is important to enable access to a variety of sciences during adolescence, when individuals are making decisions about their future educati
Publikováno v:
Journal of Neurochemistry. 134:927-942
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by an expansion of the CAG repeat in the huntingtin gene. One of the brain changes that occurs in HD is the expression of the receptor for advanced glycation end prod
Autor:
Chamini J. Perera, Preet G.S. Makker, Anthony S. Don, Thomas Fath, Justin G. Lees, Samuel S. Duffy, Brooke A Keating, Ryan S. Tonkin, Simon J. O'Carroll, Louise F.B. Nicholson, Collin Tran, Gila Moalem-Taylor, Callum Bowles, Lu Liu, Catherine A. Gorrie, Colin R. Green
Publikováno v:
Experimental neurology. 300
© 2017 Elsevier Inc. Connexin43 (Cx43) hemichannels in spinal cord astrocytes are implicated in the maintenance of neuropathic pain following peripheral nerve injury. Peptide5 is a Cx43 mimetic peptide that blocks hemichannels. In this study, we inv
Autor:
Ilva D. Rupenthal, Louise F.B. Nicholson, Helen V. Danesh-Meyer, Colin R. Green, Yeri Kim, Simon J. O'Carroll, Jarred M. Griffin, Jie Zhang, Peter S. Freestone, Monica L. Acosta, Mohd N Mat Nor
Publikováno v:
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 14(4)
The cis benzopyran compound tonabersat (SB-220453) has previously been reported to inhibit connexin26 expression in the brain by attenuating the p38-mitogen-activated protein kinase pathway. We show here that tonabersat directly inhibits connexin43 h
Publikováno v:
Experimental Neurology. 248:301-308
There is increasing evidence that connexin hemichannels, the half gap junctions that sit unopposed in the cell membrane, can open during ischemia and that blockade of connexin43 hemichannels after cerebral ischemia can improve neural outcomes. Howeve