Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Louise F. Nikolajsen"'
Autor:
Frederic A. Meunier, Andreas Papadopulos, Michael J. Waters, Yash Chhabra, Birthe B. Kragelund, Ho Yi Wong, Helena Steinocher, Louise F. Nikolajsen, Kathryn A. Tunny, Aaron G. Smith, Andrew J. Brooks
Publikováno v:
Oncogene
Chhabra, Y, Wong, H Y, Nikolajsen, L F, Steinocher, H, Papadopulos, A, Tunny, K A, Meunier, F A, Smith, A G, Kragelund, B B, Brooks, A J & Waters, M J 2018, ' A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation ', Oncogene, vol. 37, pp. 489-501 . https://doi.org/10.1038/onc.2017.352
Chhabra, Y, Wong, H Y, Nikolajsen, L F, Steinocher, H, Papadopulos, A, Tunny, K A, Meunier, F A, Smith, A G, Kragelund, B B, Brooks, A J & Waters, M J 2018, ' A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation ', Oncogene, vol. 37, pp. 489-501 . https://doi.org/10.1038/onc.2017.352
Both humans and mice lacking functional growth hormone (GH) receptors are known to be resistant to cancer. Further, autocrine GH has been reported to act as a cancer promoter. Here we present the first example of a variant of the GH receptor (GHR) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a81d5f9d47c1a41e18529c63aa687af
https://doi.org/10.1038/onc.2017.352
https://doi.org/10.1038/onc.2017.352
Mechanism of JAK2 Activation by the Archetype Class I Cytokine Receptor, the Growth Hormone Receptor
Autor:
Andrew J. Brooks, Daniel Abankwa, Yash Chhabra, Alan E. Mark, Megan L. O'Mara, Yann Gambin, Wei Dai, Guillermo A. Gomez, Louise F. Nikolajsen, Michael W. Parker, Manolis Doxastakis, Michael J. Waters, Emma Sierecki, Gitte W. Haxholm, Kathryn A. Tunny
Publikováno v:
Biophysical Journal. 110(3)
The growth hormone receptor (GHR) has been the archetype for the class I cytokine receptor family. The original paradigm for how growth hormone (GH) binding to the GHR led to activation of the associated JAK2 was based on biophysical and structural s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00532d5b9f83fdbc979eccebe21c4f3
Autor:
Suwen Zhao, Raymond C. Stevens, Walden E. Bjørn-Yoshimoto, Lu Qu, Xi Ping Huang, Jianjun Cheng, Vsevolod Katritch, Kang Ding, Michael A. Hanson, Zhi-Jie Liu, Anders A. Jensen, Petr Popov, Yao Peng, Mengchen Pu, Ling Shen, Daniel Wacker, Louise F. Nikolajsen, John D. McCorvy, Shuguang Yuan, Gye Won Han, Tao Che, Katherine Lansu, David E. Gloriam, Bryan L. Roth, Kasper Harpsøe, Yiran Wu
Publikováno v:
Cell. 172:719-730.e14
Summary Drugs frequently require interactions with multiple targets—via a process known as polypharmacology—to achieve their therapeutic actions. Currently, drugs targeting several serotonin receptors, including the 5-HT 2C receptor, are useful f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::418cf9a8ea70063f82dd0b1e4db975b9
https://doi.org/10.1016/j.cell.2018.01.001
https://doi.org/10.1016/j.cell.2018.01.001
Autor:
Helena Steinocher, Andrew J. Brooks, Kresten Lindorff-Larsen, Birthe B. Kragelund, Katrine Bugge, Louise F. Nikolajsen
Publikováno v:
Biophysical Journal. 112:171a
The Growth Hormone Receptor (GHR) is a member of the Class I Cytokine Receptor family and comprises three different domains, an extracellular domain (ECD), a cell membrane spanning helix constituting the transmembrane domain (TMD) and an intracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f14b96b36004e2c109f0420aaedb707
https://doi.org/10.1016/j.bpj.2016.11.947
https://doi.org/10.1016/j.bpj.2016.11.947
Autor:
Michael A. Hanson, David E. Gloriam, Eshita Mutt, Vignir Isberg, Raymond C. Stevens, Janne M. Bibbe, Tilman Flock, Xavier Deupi, Louise F. Nikolajsen, Christian Munk
Publikováno v:
Nature Methods
G-protein-coupled receptors (GPCRs) transduce physiological and sensory stimuli into appropriate cellular responses and mediate the actions of one-third of drugs. GPCR structural studies have revealed the general bases of receptor activation, signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bc97a92d212b2ae59ae6d81c34818b