Apoptotic priming is defined by the dynamic exchange of Bcl-2 proteins between mitochondria and cytosol

Autor: Louise E. King, Ricardo Rodriguez-Enriquez, Robert Pedley, Charlotte E. L. Mellor, Pengbo Wang, Egor Zindy, Michael R. H. White, Keith Brennan, Andrew P. Gilmore

Publikováno v: Cell Death & Differentiation. 29:2262-2274

Apoptosis is regulated by interactions between the BH3-only and multi-domain Bcl-2 family proteins. These interactions are integrated on the outer mitochondrial membrane (OMM) where they set the threshold for apoptosis, known as mitochondrial priming

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f21e57fd062a503420047e54a7f479f
https://doi.org/10.1038/s41418-022-01013-z

Apoptosis regulation at the mitochondria membrane level

Autor: Ana J. García-Sáez, Louise E. King, Shashank Dadsena

Publikováno v: Biochimica et Biophysica Acta (BBA)-Biomembranes

Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis that activates the caspase cascade and irreversibly causes the majority of cells to die. The proteins of the Bcl-2 family are master regulators of apoptosis that fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f51dde504acdf64f9fd551fac84080a

Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization

Autor: Tomomi Kuwana, Julian Suess, Louise E. King, Katia Cosentino, Donald D. Newmeyer, Andrew P. Gilmore, Ana J. García-Sáez

Publikováno v: J Biol Chem
Kuwana, T, King, L E, Cosentino, K, Suess, J, García-sáez, A J, Gilmore, A P & Newmeyer, D D 2020, ' Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization ', Journal of Biological Chemistry, pp. jbc.RA119.011635 . https://doi.org/10.1074/jbc.RA119.011635

Permeabilization of the mitochondrial outer membrane is a key step in the intrinsic apoptosis pathway, triggered by the release of mitochondrial intermembrane space proteins into the cytoplasm. The BCL-2-associated X apoptosis regulator (BAX) protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4727bc3df6df9bc59c28439e02ae66
https://pubmed.ncbi.nlm.nih.gov/31901077

E2F1 interacts with BCL-xL and regulates its subcellular localization dynamics to trigger cell death

Autor: Frédérique Braun, Andrew P. Gilmore, Laurent Maillet, Fabien Gautier, Aurélie Fétiveau, Philippe Juin, Laurence Dubrez, Cémile Kayaci, Céline Vuillier, Steven Lohard, Sophie Barillé-Nion, Jennifer Allègre, Louise E. King

Publikováno v: Vuillier, C, Lohard, S, Fétiveau, A, Allègre, J, Kayaci, C, King, L E, Braun, F, Barillé-Nion, S, Gautier, F, Dubrez, L, Gilmore, A P, Juin, P P & Maillet, L 2017, ' E2F1 interacts with BCL-xL and regulates its subcellular localization dynamics to trigger cell death ', EMBO reports . https://doi.org/10.15252/embr.201744046
EMBO Reports
EMBO Reports, EMBO Press, 2017, 〈10.15252/embr.201744046〉
EMBO Reports, EMBO Press, 2018, 19 (2), pp.234-243. ⟨10.15252/embr.201744046⟩
EMBO Reports, 2018, 19 (2), pp.234-243. ⟨10.15252/embr.201744046⟩

International audience; E2F1 is the main pro-apoptotic effector of the pRB-regulated tumor suppressor pathway by promoting the transcription of various pro-apoptotic proteins. We report here that E2F1 partly localizes to mitochondria, where it favors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9cd3296f527cb955054b0511462e17
https://pure.manchester.ac.uk/ws/files/67684278/Vuillier_et_al_EMBOR_2017_44046V3.pdf