Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Louise E, Reynolds"'
Autor:
Tanguy Lechertier, Louise E. Reynolds, Hyojin Kim, Ana Rita Pedrosa, Jesús Gómez-Escudero, José M. Muñoz-Félix, Silvia Batista, Matthew Dukinfield, Fevzi Demircioglu, Ping Pui Wong, Kylie P. Matchett, Neil C. Henderson, Gabriela D’Amico, Maddy Parsons, Catherine Harwood, Pascal Meier, Kairbaan M. Hodivala-Dilke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/33e6176c6d6a4fc595fff02b19cc1f2f
Autor:
Tanguy Lechertier, Louise E. Reynolds, Hyojin Kim, Ana Rita Pedrosa, Jesús Gómez-Escudero, José M. Muñoz-Félix, Silvia Batista, Matthew Dukinfield, Fevzi Demircioglu, Ping Pui Wong, Kylie P. Matchett, Neil C. Henderson, Gabriela D’Amico, Maddy Parsons, Catherine Harwood, Pascal Meier, Kairbaan M. Hodivala-Dilke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Abstract The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour growth, but how pericyte FAK regulates tumour angiogenesis is unknown. We show tha
Externí odkaz:
https://doaj.org/article/327b0c1e155a4263840ab94acda7cb38
Autor:
Fevzi Demircioglu, Jun Wang, Juliana Candido, Ana S. H. Costa, Pedro Casado, Beatriz de Luxan Delgado, Louise E. Reynolds, Jesus Gomez-Escudero, Emma Newport, Vinothini Rajeeve, Ann-Marie Baker, Marina Roy-Luzarraga, Trevor A. Graham, Julie Foster, Yu Wang, James J. Campbell, Rajinder Singh, Penglie Zhang, Thomas J. Schall, Frances R. Balkwill, Jane Sosabowski, Pedro R. Cutillas, Christian Frezza, Patricia Sancho, Kairbaan Hodivala-Dilke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Cancer associated fibroblasts (CAFs) have been suggested to regulate cancer cell metabolism, but the mechanisms are not completely elucidated. Here, the authors show that low FAK expression in stromal cells correlates with poor prognosis in breast an
Externí odkaz:
https://doaj.org/article/514da35f7c834a7f879f285d226a9e53
Autor:
Daniel E Foxler, Katherine S Bridge, John G Foster, Paul Grevitt, Sean Curry, Kunal M Shah, Kathryn M Davidson, Ai Nagano, Emanuela Gadaleta, Hefin I Rhys, Paul T Kennedy, Miguel A Hermida, Ting‐Yu Chang, Peter E Shaw, Louise E Reynolds, Tristan R McKay, Hsei‐Wei Wang, Paulo S Ribeiro, Michael J Plevin, Dimitris Lagos, Nicholas R Lemoine, Prabhakar Rajan, Trevor A Graham, Claude Chelala, Kairbaan M Hodivala‐Dilke, Ian Spendlove, Tyson V Sharp
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 8, Pp 1-18 (2018)
Abstract The adaptive cellular response to low oxygen tensions is mediated by the hypoxia‐inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF‐α and HIF‐β subunits. Prolonged HIF expression is a key contri
Externí odkaz:
https://doaj.org/article/9b04680e29334b599d9575042b42aeeb
Autor:
Kairbaan M. Hodivala-Dilke, Thomas Iskratsch, Maddy Parsons, Bryan Serrels, Bernardo Tavora, Silvia Batista, Annika N. Alexopoulou, Vassiliki Kostourou, Delphine M. Lees, Isabelle Fernandez, Paraskivi Natalia Georgiou, Louise E. Reynolds, Edward P. Carter, Jesus Gomez-Escudero, Natalia Bodrug, Ana-Rita Pedrosa
Supplementary Figure 1 and 2. Generation and Characterisation of ECCre+;FAKY397F/Y397F and ECCre+;FAKY861F/Y861F mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5282133926484d2f37715e73d3989246
https://doi.org/10.1158/0008-5472.22422237.v1
https://doi.org/10.1158/0008-5472.22422237.v1
Autor:
Kairbaan M. Hodivala-Dilke, Thomas Iskratsch, Maddy Parsons, Bryan Serrels, Bernardo Tavora, Silvia Batista, Annika N. Alexopoulou, Vassiliki Kostourou, Delphine M. Lees, Isabelle Fernandez, Paraskivi Natalia Georgiou, Louise E. Reynolds, Edward P. Carter, Jesus Gomez-Escudero, Natalia Bodrug, Ana-Rita Pedrosa
Supplementary Figure 6. Knocking down Ang-2 in B16F0s cells ablates angiogenic response in ECCre+;FAKY861F/Y861F mice in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ed9c4100bd25c2f70043fe68231339
https://doi.org/10.1158/0008-5472.22422225.v1
https://doi.org/10.1158/0008-5472.22422225.v1
Autor:
Kairbaan Hodivala-Dilke, Pedro R. Cutillas, Cyrill Géraud, Ping-Pui Wong, Victoria Sanz-Moreno, Dieter Saur, Peter B. Vermeulen, Ya-Ming Meng, Christof Dormann, Céline Weller, Frances M. Richards, Jesús Gómez-Escudero, Rebecca J.G. Drake, Vinothini Rajeeve, Emma Newport, Laura Wisniewski, Oscar Maiques, Beatriz de Luxán-Delgado, Louise E. Reynolds, Marina Roy-Luzarraga
Supplementary Data from Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6fbefb5bd893c63c43ec853b8f0ac9
https://doi.org/10.1158/0008-5472.22430214.v1
https://doi.org/10.1158/0008-5472.22430214.v1
Autor:
Moritz Felcht, Hellmut G. Augustin, Kairbaan M. Hodivala-Dilke, Sergij Goerdt, Markus Thomas, Jochen Utikal, Cyrill Géraud, Dorothee Terhardt, Louise E. Reynolds, Nicolas Gengenbacher, Anja Gampp, Benjamin Schieb, Carolin Mogler, Corinne Hübers, Mahak Singhal, Ashik Ahmed Abdul Pari
The angiopoietin (Angpt)–TIE signaling pathway controls vascular maturation and maintains the quiescent phenotype of resting vasculature. The contextual agonistic and antagonistic Tie2 ligand ANGPT2 is believed to be exclusively produced by endothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59e3921bd8e86136df6666680597eaf7
https://doi.org/10.1158/0008-5472.c.6511466.v1
https://doi.org/10.1158/0008-5472.c.6511466.v1
Autor:
Moritz Felcht, Hellmut G. Augustin, Kairbaan M. Hodivala-Dilke, Sergij Goerdt, Markus Thomas, Jochen Utikal, Cyrill Géraud, Dorothee Terhardt, Louise E. Reynolds, Nicolas Gengenbacher, Anja Gampp, Benjamin Schieb, Carolin Mogler, Corinne Hübers, Mahak Singhal, Ashik Ahmed Abdul Pari
This file consists of supplementary figures (SF) 1-11 consisting of: SF1: Melanoma cells express ANGPT2 (A-F). SF2: Melanoma cell-expressed Angpt2 does not modulate tumor cell proliferation (A-B). SF3: Tumor cell knockdown of Angpt2 does not impact g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449cc8e11f6161b45bdcc4084ff2d5e3
https://doi.org/10.1158/0008-5472.22423301
https://doi.org/10.1158/0008-5472.22423301
Autor:
Kairbaan M. Hodivala-Dilke, Thomas Iskratsch, Maddy Parsons, Bryan Serrels, Bernardo Tavora, Silvia Batista, Annika N. Alexopoulou, Vassiliki Kostourou, Delphine M. Lees, Isabelle Fernandez, Paraskivi Natalia Georgiou, Louise E. Reynolds, Edward P. Carter, Jesus Gomez-Escudero, Natalia Bodrug, Ana-Rita Pedrosa
Expression of focal adhesion kinase (FAK) in endothelial cells (EC) is essential for angiogenesis, but how FAK phosphorylation at tyrosine-(Y)397 and Y861 regulate tumor angiogenesis in vivo is unknown. Here, we show that tumor growth and angiogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eee9a002e76a2569618268b1a0af530
https://doi.org/10.1158/0008-5472.c.6511158.v1
https://doi.org/10.1158/0008-5472.c.6511158.v1