Výsledky vyhledávání - "Louise E, Bird"

Akademický článek

The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif

Autor: Petra Lukacik, C. David Owen, Gemma Harris, Jani Reddy Bolla, Sarah Picaud, Irfan Alibay, Joanne E. Nettleship, Louise E. Bird, Raymond J. Owens, Philip C. Biggin, Panagis Filippakopoulos, Carol V. Robinson, Martin A. Walsh

Publikováno v: PLoS ONE, Vol 16, Iss 10 (2021)

Nontypeable Haemophilus influenzae (NTHi) is a significant pathogen in respiratory disease and otitis media. Important for NTHi survival, colonization and persistence in vivo is the Sap (sensitivity to antimicrobial peptides) ABC transporter system.

Externí odkaz: https://doaj.org/article/e0a881dfff0a4bcfb91cb3fe4f1e1dcd

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Akademický článek

The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity.

Autor: Sarah Mas-Y-Mas, Marta Barbon, Catherine Teyssier, Hélène Déméné, João E Carvalho, Louise E Bird, Andrey Lebedev, Juliana Fattori, Michael Schubert, Christian Dumas, William Bourguet, Albane le Maire

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0165139 (2016)

Mixed Lineage Leukemia 5 (MLL5) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. Chromatin binding is ensured by its plant homeodomain (PHD) through a direct interaction with the N-terminus of histone H3 (H3). In additio

Externí odkaz: https://doaj.org/article/c5e2ea2db33b4a239f05a9d52d8e1be4

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Structure of a collagen VI α3 chain VWA domain array: Adaptability and functional implications of myopathy causing mutations

Autor: Mats Paulsson, Jörn M. Werner, Raimund Wagener, Dmitri I. Svergun, Carolin D. Freiburg, Herimela Solomon-Degefa, Ulrich Baumann, Cy M. Jeffries, Louise E. Bird, Jan M. Gebauer, Elmar Behrmann, Patrick Meckelburg, Raymond J. Owens

Publikováno v: 'Journal of Biological Chemistry ', vol: 295, pages: 12755-12771 (2020)
The Journal of Biological Chemistry
JBC papers in press 295(36), 12755-12771 (2020). doi:10.1074/jbc.RA120.014865
J Biol Chem

Collagen VI is a ubiquitous heterotrimeric protein of the extracellular matrix (ECM) that plays an essential role in the proper maintenance of skeletal muscle. Mutations in collagen VI lead to a spectrum of congenital myopathies, from the mild Bethle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544667f612a25c7465f5e7554222d7c9
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:55852

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Crystallographic approach to fragment-based hit discovery against Schistosoma mansoni purine nucleoside phosphorylase

Autor: Louise E. Bird, Muhammad Faheem, Juliana Roberta Torini, Nicholas M Pearce, Humberto D'Muniz Pereira, Raymond J. Owens, José Brandão-Neto, Dom Bellini, João Alexandre Ribeiro Gonçalves Barbosa, Frank von Delft, Napoleão Fonseca Valadares, P.M. Collins

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Several Schistosoma species cause Schistosomiasis, an endemic disease in 78 countries that is ranked second amongst the parasitic diseases in terms of its socioeconomic impact and human health importance. The drug recommended for treatment by the WHO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ac4904581b9efac3887c75a8205aa3
https://pubmed.ncbi.nlm.nih.gov/34529035

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The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif

Autor: Joanne E. Nettleship, Martin A. Walsh, Panagis Filippakopoulos, Sarah Picaud, Philip C. Biggin, Gemma Harris, Louise E. Bird, Petra Lukacik, Carol V. Robinson, Irfan Alibay, C. David Owen, Raymond J. Owens, Jani Reddy Bolla

Publikováno v: PLoS ONE, Vol 16, Iss 10, p e0256070 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43947534db5a9690a6847f30f538eff4
https://doaj.org/article/3848955c7713409e903d25b26102d894

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The Dual PDZ Domain from Postsynaptic Density Protein 95 Forms a Scaffold with Peptide Ligand

Autor: Michael P. Lockhart-Cairns, Nazahiyah Ahmad Rodzli, Stephen M. Prince, John Chipperfield, Clair Baldock, Colin Levy, Louise E. Bird

Publikováno v: Biophysical journal 119(3), 667-689 (2020). doi:10.1016/j.bpj.2020.06.018
Rodzli, N, Lockhart, M, Levy, C W, Chipperfield, J, Bird, L, Baldock, C & Prince, S M 2020, ' The dual PDZ domain from Postsynaptic density protein 95 forms a scaffold with peptide ligand ', Biophysical Journal, vol. 119, no. 3, pp. 667-689 . https://doi.org/10.1016/j.bpj.2020.06.018
Biophysical Journal

Biophysical journal 119(3), 667 - 689 (2020). doi:10.1016/j.bpj.2020.06.018
PSD-95 is a member of the membrane-associated guanylate kinase class of proteins that forms scaffolding interactions with partner proteins, including ion and receptor ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29252dd697f8e6d5966e4fbba77c521b
https://bib-pubdb1.desy.de/record/454411

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Surveying GPCR solubilisation conditions using surface plasmon resonance

Autor: Tonia Aristotelous, Andrew L. Hopkins, Iva Navratilova, Louise E Bird

Publikováno v: Analytical Biochemistry. 556:23-34

Biophysical screening techniques, such as surface plasmon resonance, enable detailed kinetic analysis of ligands binding to solubilised G-protein coupled receptors. The activity of a receptor solubilised out of the membrane is crucially dependent on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74764f75f3c67e81c8b1ea82fa093afe
https://doi.org/10.1016/j.ab.2018.06.012

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Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites

Autor: Paul W. Denny, Ehmke Pohl, Amjed Qays Al-Qaisi, Morten K. Grøftehauge, Louise E. Bird, Hosam Shams-Eldin, Julie K. Thye, Steven Pratt, Robert H. Dods, Jackie A. Mosely, John G. Mina, Ralph T. Schwarz

Publikováno v: The Journal of Biological Chemistry
Journal of biological chemistry, 2017, Vol.292(29), pp.12208-12219 [Peer Reviewed Journal]

Toxoplasma gondii is an obligate, intracellular eukaryotic apicomplexan protozoan parasite that can cause fetal damage and abortion in both animals and humans. Sphingolipids are essential and ubiquitous components of eukaryotic membranes that are bot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7d2f9725c0290d3ed912353f3931f1
https://doi.org/10.1074/jbc.m117.792374

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How the dual PDZ domain from Postsynaptic density protein 95 clusters ion channels and receptors

Autor: Louise E. Bird, Nazahiyah Ahmad Rodzli, John Chipperfield, Clair Baldock, Michael P. Lockhart-Cairns, Colin Levy, Stephen M. Prince

PSD-95 is a member of Membrane Associated Guanylate Kinase class of proteins which form scaffolding interactions with partner proteins including ion and receptor channels. PSD-95 is directly implicated in modulating the electrical responses of excita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4064ddbbcdcd7fc7dae7f8579530fe93

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Characterization of a Schistosoma mansoni NDPK expressed in sexual and digestive organs

Autor: Adriano de Freitas Fernandes, Ricardo DeMarco, Vitor Serrão, L. Romanello, Joanne E. Nettleship, José Brandão-Neto, Raymond J. Owens, Ana Eliza Zeraik, Juliana Roberta Torini, Louise E. Bird, Humberto D'Muniz Pereira

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Nucleoside diphosphate kinases (NDPKs) are crucial to keep the high triphosphate nucleotide levels in the biological process. The enzymatic mechanism has been extensively described; however, the structural characteristics and kinetic parameters have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7923ad2c5527aa4b1614a2a5b92f10d
https://pubmed.ncbi.nlm.nih.gov/31103556

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