Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Louise Doyon"'
Autor:
Alexandre Gagnon, René Coulombe, Michel Garneau, Araz Jakalian, Patrick Deroy, Bruno Simoneau, Jianmin Duan, Serge Landry, Eric Jolicoeur, Christiane Yoakim, Pierre R. Bonneau, Louise Doyon, Ingrid Guse, Eric Malenfant, Ma’an Amad
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4437-4441
A series of aryl thiotetrazolylacetanilides were synthesized and found to be potent inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases. The incorporation of an alkynyl fragment on the aniline provided inhibitors wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf01669bc7d576254bca643b9f8ed93
https://doi.org/10.1016/j.bmcl.2007.06.012
https://doi.org/10.1016/j.bmcl.2007.06.012
Publikováno v:
Antiviral Research. 68:27-35
Tipranavir is a novel, non-peptidic protease inhibitor, which possesses broad antiviral activity against multiple protease inhibitor-resistant HIV-1. Resistance to this inhibitor however has not yet been well described. HIV was passaged for 9 months
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e615dc6fd45b93c3a9163b8378f8d9fa
https://doi.org/10.1016/j.antiviral.2005.07.003
https://doi.org/10.1016/j.antiviral.2005.07.003
Publikováno v:
Cellular Immunology. 187:124-130
Mice infected with murine acquired immunodeficiency syndrome (MAIDS) virus developed lymphoadenopathy and profound immunodeficiency. Concomitantly the expression of endogenous mammary tumor virus (MTV) mRNA increased significantly, especially for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2cbc582d086305f7935d5271bbef83
https://doi.org/10.1006/cimm.1998.1326
https://doi.org/10.1006/cimm.1998.1326
Publikováno v:
Journal of Virology. 72:6146-6150
Human immunodeficiency virus type 1 (HIV-1) variants resistant to protease inhibitors have been shown to contain a mutation in the p1/p6 Gag precursor cleavage site. At the messenger RNA level, this mutation generates a U UUU UUU sequence that is rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4335f93d2a74eda0c44ab7e2aea1709
https://doi.org/10.1128/jvi.72.7.6146-6150.1998
https://doi.org/10.1128/jvi.72.7.6146-6150.1998
Publikováno v:
Journal of Virology. 70:3763-3769
Protease inhibitors are potent antiviral agents against human immunodeficiency virus type 1. As with reverse transcriptase inhibitors, however, resistance to protease inhibitors can develop and is attributed to the appearance of mutations in the prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bdd6ef7e7a20d64ce157a16392d368
https://doi.org/10.1128/jvi.70.6.3763-3769.1996
https://doi.org/10.1128/jvi.70.6.3763-3769.1996
Publikováno v:
Antimicrobial Drug Resistance ISBN: 9781603275927
The HIV-1 genome encodes an essential protease enzyme which is one of the major targets of antiviral therapy (1–3). Protease inhibitors (PIs) have been proven to be potent antiviral agents and their introduction in 1995 led to the era of highly act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09b1023fbda91cb05a403d2a83a2e6a5
https://doi.org/10.1007/978-1-59745-180-2_34
https://doi.org/10.1007/978-1-59745-180-2_34
Autor:
William W. Ogilvie, Serge Landry, Eric Malenfant, Jianmin Duan, Pierre R. Bonneau, Michel Garneau, Michael Bös, Bruno Simoneau, Julie Naud, Robert Deziel, Jeff A. O'Meara, Michael G. Cordingley, Christiane Yoakim, Bounkham Thavonekham, Louise Doyon, Ingrid Guse
Publikováno v:
Journal of medicinal chemistry. 48(17)
A series of novel 8-substituted dipyridodiazepinone-based inhibitors were investigated for their antiviral activity against wild type human immunodeficiency virus (HIV-1) and the clinically prevalent K103N/Y181C mutant virus. Our efforts have resulte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76001c69f732e210f2c8aafb7334835
https://pubmed.ncbi.nlm.nih.gov/16107158
https://pubmed.ncbi.nlm.nih.gov/16107158
Autor:
Peter W. White, Jacques Archambault, Michael G. Cordingley, Louise Thauvette, William W. Ogilvie, Steve Titolo, Karine Brault, Alex Pelletier, Ewald Welchner, Christiane Yoakim, Louise Doyon, Lise Bourgon
Publikováno v:
The Journal of biological chemistry. 278(29)
Human papillomavirus (HPV) DNA replication is initiated by recruitment of the E1 helicase by the E2 protein to the viral origin. Screening of our corporate compound collection with an assay measuring the cooperative binding of E1 and E2 to the origin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0c540be53e6d80b0a872dd60f661bf
https://pubmed.ncbi.nlm.nih.gov/12730224
https://pubmed.ncbi.nlm.nih.gov/12730224
Publikováno v:
Journal of virology. 71(2)
One hope to maintain the benefits of antiviral therapy against the human immunodeficiency virus type 1 (HIV-1), despite the development of resistance, is the possibility that resistant variants will show decreased viral fitness. To study this possibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fd7dbc06eac83b1f96d7f166ff0cc8
https://pubmed.ncbi.nlm.nih.gov/8995629
https://pubmed.ncbi.nlm.nih.gov/8995629