Testing a breast cancer prevention and a multiple disease prevention weight loss programme amongst women within the UK NHS breast screening programme—a randomised feasibility study

Autor: Michelle Harvie, David P. French, Mary Pegington, Grace Cooper, Anthony Howell, Sarah McDiarmid, Cheryl Lombardelli, Louise Donnelly, Helen Ruane, Katharine Sellers, Emma Barrett, Christopher J. Armitage, D. Gareth Evans

Publikováno v: Pilot and Feasibility Studies, Vol 7, Iss 1, Pp 1-16 (2021)

Abstract Background Excess weight and unhealthy behaviours (e.g. sedentariness, high alcohol) are common amongst women including those attending breast screening. These factors increase the risk of breast cancer and other diseases. We tested the feas

Externí odkaz: https://doaj.org/article/8bf1d05021e043e6bc5930c055570ebb

Initiation of glucose‐lowering drugs reduces the anticoagulant effect of warfarin—But not through altered drug metabolism in patients with type 2 diabetes

Autor: Ann‐Cathrine Dalgård Dunvald, Flemming Nielsen, Dorte Aalund Olsen, Martin Thomsen Ernst, Louise Donnelly, Enrique Soto‐Pedre, Maja Refshauge Kristiansen, Jens Steen Nielsen, Frederik Persson, Kurt Højlund, Jonna Skov Madsen, Jens Søndergaard, Ewan Pearson, Anton Pottegård, Tore Bjerregaard Stage

Publikováno v: British Journal of Clinical Pharmacology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d5190bbb76b14886499b3c9895f6855
https://doi.org/10.1111/bcp.15725

Coordinated nasal mucosa-mediated immunity accelerates recovery from COVID-19

Autor: Steven Cass, Dan Nicolau, Jonathan Baker, Christine Mwasuku, Sanjay Ramakrishnan, Mahdi Mahdi, Peter Barnes, Louise Donnelly, Rocio T. Martinez-Nunez, Richard Russell, Mona Bafadhel

Viral infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induce a dynamic immune environment. Using nasal mucosal samples in 139 participants from the STOIC study (community-based randomised clinical trial for the use of bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee9d795b1e906091a34ba1b0caf2771e
https://doi.org/10.21203/rs.3.rs-2666607/v1

Photochemically Controlled Drug Dosing from a Polymeric Scaffold

Autor: Sean P. Gorman, Colin P. McCoy, John G. Hardy, Louise Donnelly, Nicola Irwin, David S. Jones

Publikováno v: Pharmaceutical Research
Donnelly, L, Hardy, J G, Gorman, S P, Jones, D S, Irwin, N J & McCoy, C P 2017, ' Photochemically controlled drug dosing from a polymeric scaffold ', Molecular Pharmaceutics . https://doi.org/10.1007/s11095-017-2164-9

Purpose To develop the first photoactive biomaterial coating capable of controlled drug dosing via inclusion of synthesised drug-3,5-dimethoxybenzoin (DMB) conjugates in a poly(2- methyoxyethyl acrylate) (pMEA) scaffold.Methods Flurbiprofen- and napr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83827b0c9d94f32f358db2e088c22d5
https://doi.org/10.1007/s11095-017-2164-9

Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery

Autor: Niamh McGoldrick, Maelíosa T.C. McCrudden, Ryan F. Donnelly, Colin P. McCoy, Eneko Larrañeta, Louise Donnelly, Nicola Irwin, Katarzyna Migalska, John G. Hardy

Publikováno v: Hardy, J G, Larrañeta, E, Donnelly, R F, McGoldrick, N, Migalska, K, McCrudden, M T C, Irwin, N J, Donnelly, L & McCoy, C P 2016, ' Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery ', Molecular Pharmaceutics, vol. 13, no. 3, pp. 907-914 . https://doi.org/10.1021/acs.molpharmaceut.5b00807

We describe, for the first time, stimuli-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically-relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdb2f88adcbd46f87cab5e241ba6fd6
https://doi.org/10.1021/acs.molpharmaceut.5b00807