Fatty acid type–specific regulation of SIRT1 does not affect insulin sensitivity in human skeletal muscle

Autor: Jørgen F. P. Wojtaszewski, Jacob Jeppesen, Andreas M. Fritzen, Henrik Hall Deleuran, Louise D. Høeg, Erik A. Richter, Bente Kiens, Kim A. Sjøberg, Anne-Marie Lundsgaard

Publikováno v: The FASEB Journal. 33:5510-5519

The nicotinamide adenine dinucleotide-dependent deacetylase, sirtuin (SIRT)1, in skeletal muscle is reduced in insulin-resistant states. However, whether this is an initial mechanism responsible for mediating insulin resistance in human skeletal musc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839ee006a5f1447a0073aca1c062fcd9
https://doi.org/10.1096/fj.201801950r

Adaptations in Mitochondrial Enzymatic Activity Occurs Independent of Genomic Dosage in Response to Aerobic Exercise Training and Deconditioning in Human Skeletal Muscle

Autor: Bente Kiens, Lotte Risom, Frank B Thøgersen, Tina D. Jeppesen, Andreas M. Fritzen, Christoffer Rasmus Vissing, Thomas Krag, Louise D. Høeg, Flemming Wibrand, Morten Duno, Kasper Thybo, Cristina Ruiz-Ruiz, John Vissing

Publikováno v: Cells
Volume 8
Issue 3
Fritzen, A M, Thøgersen, F B, Thybo, K, Vissing, C R, Krag, T O, Ruiz-Ruiz, C, Risom, L, Wibrand, F, Høeg, L D, Kiens, B, Duno, M, Vissing, J & Jeppesen, T D 2019, ' Adaptations in mitochondrial enzymatic activity occurs independent of genomic dosage in response to aerobic exercise training and deconditioning in human skeletal muscle ', Cells, vol. 8, no. 3, 237 . https://doi.org/10.3390/cells8030237
Cells, Vol 8, Iss 3, p 237 (2019)

Mitochondrial DNA (mtDNA) replication is thought to be an integral part of exercise-training-induced mitochondrial adaptations. Thus, mtDNA level is often used as an index of mitochondrial adaptations in training studies. We investigated the hypothes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81518dcd136a7441ca0ffd2aec35a12e

Contraction-induced lipolysis is not impaired by inhibition of hormone-sensitive lipase in skeletal muscle

Autor: Annette K. Serup, Henrik Galbo, Bente Kiens, Louise D. Høeg, Cecilia Holm, Peter Schjerling, Robert Zimmermann, Thomas J. Alsted, Thorkil Ploug, Christian Fledelius, Clara Prats

Publikováno v: The Journal of Physiology. 591:5141-5155

In skeletal muscle hormone-sensitive lipase (HSL) has long been accepted to be the principal enzyme responsible for lipolysis of intramyocellular triacylglycerol (IMTG) during contractions. However, this notion is based on in vitro lipase activity da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8891daea6d92b0ec1f0ccf59e2970a9e
https://doi.org/10.1113/jphysiol.2013.260794

Exercise Alleviates Lipid-Induced Insulin Resistance in Human Skeletal Muscle–Signaling Interaction at the Level of TBC1 Domain Family Member 4

Autor: Jesper B. Birk, Louise D. Høeg, Erik A. Richter, Bente Kiens, Nina Brandt, Laurie J. Goodyear, Kim A. Sjøberg, Jørgen F. P. Wojtaszewski, Christian Pehmøller

Publikováno v: Diabetes

Excess lipid availability causes insulin resistance. We examined the effect of acute exercise on lipid-induced insulin resistance and TBC1 domain family member 1/4 (TBCD1/4)-related signaling in skeletal muscle. In eight healthy young male subjects,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3caa7ea13ee885f9a9727172b9b6aaa
https://doi.org/10.2337/db11-1572

Higher intramuscular triacylglycerol in women does not impair insulin sensitivity and proximal insulin signaling

Autor: Carsten Roepstorff, Erik A. Richter, Bente Kiens, Jørgen F. P. Wojtaszewski, Louise D. Høeg, Maja Thiele

Publikováno v: Journal of applied physiology (Bethesda, Md. : 1985). 107(3)

Women have been shown to have higher muscle triacylglycerol (IMTG) levels than men and could therefore be expected to have lower insulin sensitivity than men, since previous studies have linked high IMTG to decreased insulin sensitivity. Therefore, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0439739e13cd4eeb36f9828e010b5bec
https://pubmed.ncbi.nlm.nih.gov/19574502