Studying the Interactions of U24 from HHV-6 in Order to Further Elucidate Its Potential Role in MS

Autor: Keng-Shuo Pi, Daria Bortolotti, Yurou Sang, Giovanna Schiuma, Silvia Beltrami, Sabrina Rizzo, Alessandra Bortoluzzi, Eleonora Baldi, A. Louise Creagh, Charles A. Haynes, Roberta Rizzo, Suzana K. Straus

Publikováno v: Viruses, Vol 14, Iss 11, p 2384 (2022)

A number of studies have suggested that human herpesvirus 6A (HHV-6A) may play a role in multiple sclerosis (MS). Three possible hypotheses have been investigated: (1) U24 from HHV-6A (U24-6A) mimics myelin basic protein (MBP) through analogous phosp

Externí odkaz: https://doaj.org/article/357b2295c4ec4a3a9c63046ff5c04217

Molecular Dissection of Xyloglucan Recognition in a Prominent Human Gut Symbiont

Autor: Alexandra S. Tauzin, Kurt J. Kwiatkowski, Nicole I. Orlovsky, Christopher J. Smith, A. Louise Creagh, Charles A. Haynes, Zdzislaw Wawrzak, Harry Brumer, Nicole M. Koropatkin

Publikováno v: mBio, Vol 7, Iss 2 (2016)

ABSTRACT Polysaccharide utilization loci (PUL) within the genomes of resident human gut Bacteroidetes are central to the metabolism of the otherwise indigestible complex carbohydrates known as “dietary fiber.” However, functional characterization

Externí odkaz: https://doaj.org/article/2694822f477d47c4b5977407768fbb46

Adaptation of Syntenic Xyloglucan Utilization Loci of Human Gut Bacteroidetes to Polysaccharide Side Chain Diversity

Autor: Stuart W. Bennett, Harry Brumer, A. Louise Creagh, Alexandra S. Tauzin, Guillaume Déjean

Publikováno v: Applied and Environmental Microbiology
Applied and Environmental Microbiology, American Society for Microbiology, 2019, 85 (20), ⟨10.1128/AEM.01491-19⟩
Applied and Environmental Microbiology, 2019, 85 (20), ⟨10.1128/AEM.01491-19⟩

Genome sequencing has revealed substantial variation in the predicted abilities of individual species within animal gut microbiota to metabolize the complex carbohydrates comprising dietary fiber. At the same time, a currently limited body of functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad12f8e82a88783f6412e2fb280e1e35
https://hal.inrae.fr/hal-02966599

Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors

Autor: Genmin Lu, Srinivas Abbina, Mark Karbarz, A. Louise Creagh, Manu Thomas Kalathottukaren, Charles A. Haynes, Pamela B. Conley, Anjali Pandey, Jayachandran N. Kizhakkedathu

Anticoagulants such as unfractionated heparin (UFH), low-molecular-weight heparins (LMWHs), fondaparinux, and direct oral anticoagulants (DOACs) targeting thrombin (IIa) or factor Xa (FXa) are widely used in prevention and treatment of thromboembolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf0c34ee188d23eeb014642b0cdbdb2
https://europepmc.org/articles/PMC6113616/

A new mixed-mode model for interpreting and predicting protein elution during isoelectric chromatofocusing

Autor: Eric von Lieres, A. Louise Creagh, Derek Choy, Charles A. Haynes

Publikováno v: Biotechnology and Bioengineering. 111:925-936

Experimental data are combined with classic theories describing electrolytes in solution and at surfaces to define the primary mechanisms influencing protein retention and elution during isoelectric chromatofocusing (ICF) of proteins and protein mixt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca906bba3afe0a60d4f0aefbcc11417f
https://doi.org/10.1002/bit.25166