Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Louise C, Serpell"'
Autor:
Rafael O. Moreno-Tortolero, Yijie Luo, Fabio Parmeggiani, Nick Skaer, Robert Walker, Louise C. Serpell, Chris Holland, Sean A. Davis
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Fibroins’ transition from liquid to solid is fundamental to spinning and underpins the impressive native properties of silk. Herein, we establish a fibroin heavy chain fold for the Silk-I polymorph, which could be relevant for other simila
Externí odkaz:
https://doaj.org/article/220e309ec4b64949825d1fe31c79ddab
Autor:
Zaid Muhammad, Phoebe W. Brown, Larema Babazau, Abdulrahman I. Alkhamis, Baba W. Goni, Haruna A. Nggada, Kefas M. Mbaya, Selina Wray, Isa H. Marte, Celeste M. Karch, Louise C. Serpell, Mahmoud B. Maina
Publikováno v:
Stem Cell Research, Vol 80, Iss , Pp 103503- (2024)
Genetic backgrounds influence cellular phenotypes, drug responses, and health outcomes, yet most human iPSC lines are derived from individuals of European descent, with lines from indigenous Africans particularly scarce. Addressing this gap, we gener
Externí odkaz:
https://doaj.org/article/c6d390ba54254cd6a3c68b1584f11a95
Autor:
Chen Lyu, Stefano Da Vela, Youssra Al-Hilaly, Karen E. Marshall, Richard Thorogate, Dmitri Svergun, Louise C. Serpell, Annalisa Pastore, Diane P. Hanger
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/8d84e8da21eb45a592eba0b8d3402fde
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Oxidative stress is a significant source of damage that accumulates during aging and contributes to Alzheimer’s disease (AD) pathogenesis. Oxidation of proteins can give rise to covalent links between adjacent tyrosines known as dityrosine (DiY) cr
Externí odkaz:
https://doaj.org/article/70a09f36edf04aff9cce76085be19d7f
Autor:
Youssra K. Al-Hilaly, Connor Hurt, Janet E. Rickard, Charles R. Harrington, John M. D. Storey, Claude M. Wischik, Louise C. Serpell, Ansgar B. Siemer
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Aggregation of the tau protein into fibrillar cross-β aggregates is a hallmark of Alzheimer’s diseases (AD) and many other neurodegenerative tauopathies. Recently, several core structures of patient-derived tau paired helical filaments (PHFs) have
Externí odkaz:
https://doaj.org/article/594cc6b618014d32a8d39a0d9b3fe5ca
Autor:
Devkee M. Vadukul, Céline Vrancx, Pierre Burguet, Sabrina Contino, Nuria Suelves, Louise C. Serpell, Loïc Quinton, Pascal Kienlen-Campard
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract A key hallmark of Alzheimer’s disease is the extracellular deposition of amyloid plaques composed primarily of the amyloidogenic amyloid-β (Aβ) peptide. The Aβ peptide is a product of sequential cleavage of the Amyloid Precursor Protein
Externí odkaz:
https://doaj.org/article/cffde72cfd7a458c9a29c038453f9d37
Autor:
Chen Lyu, Stefano Da Vela, Youssra Al-Hilaly, Karen E. Marshall, Richard Thorogate, Dmitri Svergun, Louise C. Serpell, Annalisa Pastore, Diane P. Hanger
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Tau35 is a truncated form of tau found in human brain in a subset of tauopathies. Tau35 expression in mice recapitulates key features of human disease, including progressive increase in tau phosphorylation, along with cognitive and motor dysfunction.
Externí odkaz:
https://doaj.org/article/be685484133d4c3a8d3091c5db1f9df6
Autor:
Pedro M. Martins, Susanna Navarro, Alexandra Silva, Maria F. Pinto, Zsuzsa Sárkány, Francisco Figueiredo, Pedro José Barbosa Pereira, Francisca Pinheiro, Zuzana Bednarikova, Michał Burdukiewicz, Oxana V. Galzitskaya, Zuzana Gazova, Cláudio M. Gomes, Annalisa Pastore, Louise C. Serpell, Rostislav Skrabana, Vytautas Smirnovas, Mantas Ziaunys, Daniel E. Otzen, Salvador Ventura, Sandra Macedo-Ribeiro
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Reports on phase separation and amyloid formation for multiple proteins and aggregation-prone peptides are recurrently used to explore the molecular mechanisms associated with several human diseases. The information conveyed by these reports can be u
Externí odkaz:
https://doaj.org/article/fc44793c97ba412084f310dcf7f683f9
Autor:
Sebastian S. Oakley, Mahmoud B. Maina, Karen E. Marshall, Youssra K. Al-Hilaly, Charlie R. Harrington, Claude M. Wischik, Louise C. Serpell
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Tau plays an important pathological role in a group of neurodegenerative diseases called tauopathies, including Alzheimer's disease, Pick's disease, chronic traumatic encephalopathy and corticobasal degeneration. In each disease, tau self-assembles a
Externí odkaz:
https://doaj.org/article/5b7b64b5eba24b5790a5b05d5ddc4ab8
Autor:
Mahmoud B. Maina, Gunasekhar Burra, Youssra K. Al-Hilaly, Kurtis Mengham, Kate Fennell, Louise C. Serpell
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101537- (2020)
Summary: Dityrosine (DiY), via the cross-linking of tyrosine residues, is a marker of protein oxidation, which increases with aging. Amyloid-β (Aβ) forms DiY in vitro and DiY-cross-linked Aβ is found in the brains of patients with Alzheimer diseas
Externí odkaz:
https://doaj.org/article/4f3367717ded4dfe87b1faeb3c86248f