An isoform of the giant protein titin is a master regulator of human T lymphocyte trafficking

Autor: Lara Toffali, Beatrice D’Ulivo, Cinzia Giagulli, Alessio Montresor, Elena Zenaro, Massimo Delledonne, Marzia Rossato, Barbara Iadarola, Andrea Sbarbati, Paolo Bernardi, Gabriele Angelini, Barbara Rossi, Nicola Lopez, Wolfgang A. Linke, Andreas Unger, Dario Di Silvestre, Louise Benazzi, Antonella De Palma, Sara Motta, Gabriela Constantin, Pierluigi Mauri, Carlo Laudanna

Publikováno v: Cell Reports, Vol 42, Iss 5, Pp 112516- (2023)

Summary: Response to multiple microenvironmental cues and resilience to mechanical stress are essential features of trafficking leukocytes. Here, we describe unexpected role of titin (TTN), the largest protein encoded by the human genome, in the regu

Externí odkaz: https://doaj.org/article/170109d87daa42509161d0df15919a04

Biomarker discovery in asthma and COPD by proteomic approaches

Autor: Anna Maria Riccio, Rossana Rossi, Louise Benazzi, Antonella De Palma, Pierluigi Mauri, Giorgio Walter Canonica

Publikováno v: PROTEOMICS - Clinical Applications. 8:901-915

Asthma and chronic obstructive pulmonary disease (COPD) are multifactorial respiratory diseases, characterized by reversible and irreversible airway obstruction, respectively. Even if the primary causes of these diseases remain unknown, inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c5054d5d89ee79711875d29dc29706
https://doi.org/10.1002/prca.201300108

Selenocysteine oxidation in glutathione peroxidase catalysis: an MS-supported quantum mechanics study

Autor: Laura Orian, Stefano Toppo, Matilde Maiorino, Antonella Roveri, Giovanni Miotto, Antonino Polimeno, Pierluigi Mauri, Leopold Flohé, Louise Benazzi, Valentina Bosello-Travain, Fulvio Ursini, Antonella De Palma, Mattia Zaccarin

Publikováno v: Free radical biology & medicine 87 (2015): 1–14. doi:10.1016/j.freeradbiomed.2015.06.011
info:cnr-pdr/source/autori:Orian L.; Mauri P.; Roveri A.; Toppo S.; Benazzi L.; Bosello-Travain V.; De Palma A.; Maiorino M.; Miotto G.; Zaccarin M.; Polimeno A.; Flohe L.; Ursini F./titolo:Selenocysteine oxidation in glutathione peroxidase catalysis: An MS-supported quantum mechanics study/doi:10.1016%2Fj.freeradbiomed.2015.06.011/rivista:Free radical biology & medicine/anno:2015/pagina_da:1/pagina_a:14/intervallo_pagine:1–14/volume:87

Glutathione peroxidases (GPxs) are enzymes working with either selenium or sulfur catalysis. They adopted diverse functions ranging from detoxification of H2O2 to redox signaling and differentiation. The relative stability of the selenoenzymes, howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2e31250f29e89dd01f8bc2a3819c73
https://pubmed.ncbi.nlm.nih.gov/26163004

The Circulating Level of FABP3 Is an Indirect Biomarker of MicroRNA-1

Autor: Francesca Varrone, PHD, Barbara Gargano, Pierluigi Carullo, BSC, +? Dario Di Silvestre, § Antonella De Palma, § Ludovica Grasso, Carolina Di Somma, ¶ Pierluigi Mauri, § Louise Benazzi, § Anna Franzone, Gloria Saccani Jotti, Marie-Louise Bang, +? Giovanni Esposito, Annamaria Colao, Gianluigi Condorelli, +? Daniele Catalucci, PHD+?

Publikováno v: Journal of the American College of Cardiology (Online) (2012).
info:cnr-pdr/source/autori:Francesca Varrone, PHD,* Barbara Gargano, PHD,* Pierluigi Carullo, BSC,+? Dario Di Silvestre, PHD,§ Antonella De Palma, PHD,§ Ludovica Grasso, MD,? Carolina Di Somma, MD,¶ Pierluigi Mauri, PHD,§ Louise Benazzi, PHD,§ Anna Franzone, MD,# Gloria Saccani Jotti, MD, PHD,** Marie-Louise Bang, PHD,+? Giovanni Esposito, MD, PHD,# Annamaria Colao, MD, PHD,? Gianluigi Condorelli, MD, PHD,+? Daniele Catalucci, PHD+?/titolo:The Circulating Level of FABP3 Is an Indirect Biomarker of MicroRNA-1/doi:/rivista:Journal of the American College of Cardiology (Online)/anno:2012/pagina_da:/pagina_a:/intervallo_pagine:/volume

OBJECTIVES: This study sought to identify proteins from the cardiomyocyte (CM) secretome that are directly targeted by the muscle-specific microRNA-1 (miR-1), and thus reflect the pathophysiological state of the CM. BACKGROUND: MicroRNAs play critica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::6e7b3ce347b3d9f19a2b914d0f27c457
https://publications.cnr.it/doc/192141

Proteomics of bronchial biopsies: Galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients

Autor: Laura De Ferrari, Dario Di Silvestre, Anna Maria Riccio, Stephen T. Holgate, Giorgio Walter Canonica, Pierluigi Mauri, Rossana Rossi, Roberto W. Dal Negro, Louise Benazzi

Publikováno v: Immunology letters 162 (2014): 2–10. doi:10.1016/j.imlet.2014.08.010
info:cnr-pdr/source/autori:Mauri, Pierluigi; Riccio, Anna Maria; Rossi, Rossana; Di Silvestre, Dario; Benazzi, Louise; De Ferrari, Laura; Dal Negro, Roberto Walter; Holgate, Stephen T.; Canonica, Giorgio Walter/titolo:Proteomics of bronchial biopsies: Galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients/doi:10.1016%2Fj.imlet.2014.08.010/rivista:Immunology letters/anno:2014/pagina_da:2/pagina_a:10/intervallo_pagine:2–10/volume:162

Asthma is a chronic inflammatory disease. Reticular basement membrane (RBM) thickening is considered feature of airway remodelling (AR) particularly in severe asthma (SA). Omalizumab, mAb to IgE is effective in SA and can modulate AR. Herein we descr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd205d5652a543660a73fd165e0c94d3