Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Louise Barys"'
Autor:
Inês A. M. Barbosa, Rajaraman Gopalakrishnan, Samuele Mercan, Thanos P. Mourikis, Typhaine Martin, Simon Wengert, Caibin Sheng, Fei Ji, Rui Lopes, Judith Knehr, Marc Altorfer, Alicia Lindeman, Carsten Russ, Ulrike Naumann, Javad Golji, Kathleen Sprouffske, Louise Barys, Luca Tordella, Dirk Schübeler, Tobias Schmelzle, Giorgio G. Galli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract YAP is a key transcriptional co-activator of TEADs, it regulates cell growth and is frequently activated in cancer. In Malignant Pleural Mesothelioma (MPM), YAP is activated by loss-of-function mutations in upstream components of the Hippo p
Externí odkaz:
https://doaj.org/article/e2b59d291ce047f9846c8773ccba1759
Autor:
Thomas Yau, Ignacio Garrido-Laguna, Pierre-Eric Juif, Markus Joerger, Anna Spreafico, Todd M Bauer, Chia-Chi Lin, Armando Santoro, Richard Greil, Helen Evans, Marc Pelletier, Toshikiko Doi, Maria-Elisabeth Goebeler, Viviana Cremasco, Marie Luise Hütter-Krönke, Antonella Perotti, Darlene Lu, Louise Barys, Claire Fabre
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background NIS793 is a human IgG2 monoclonal antibody that binds to transforming growth factor beta (TGF-β). This first-in-human study investigated NIS793 plus spartalizumab treatment in patients with advanced solid tumors.Methods Patients received
Externí odkaz:
https://doaj.org/article/e339d08408a2485f90c3737b27e2f7e9
Autor:
Melusine Bleu, Fanny Mermet-Meillon, Verena Apfel, Louise Barys, Laura Holzer, Marianne Bachmann Salvy, Rui Lopes, Inês Amorim Monteiro Barbosa, Cecile Delmas, Alexandra Hinniger, Suzanne Chau, Markus Kaufmann, Simon Haenni, Karolin Berneiser, Maria Wahle, Ivana Moravec, Alexandra Vissières, Tania Poetsch, Erik Ahrné, Nathalie Carte, Johannes Voshol, Elisabeth Bechter, Jacques Hamon, Marco Meyerhofer, Dirk Erdmann, Matteo Fischer, Therese Stachyra, Felix Freuler, Sascha Gutmann, César Fernández, Tobias Schmelzle, Ulrike Naumann, Guglielmo Roma, Kate Lawrenson, Cristina Nieto-Oberhuber, Amanda Cobos-Correa, Stephane Ferretti, Dirk Schübeler, Giorgio Giacomo Galli
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extrace
Externí odkaz:
https://doaj.org/article/e459f346777c48fab385e6b2235f6c4c
Autor:
Chrysiis Michaloglou, Waltraut Lehmann, Typhaine Martin, Clara Delaunay, Andreas Hueber, Louise Barys, Honglin Niu, Eric Billy, Markus Wartmann, Moriko Ito, Christopher J Wilson, Mary Ellen Digan, Andreas Bauer, Hans Voshol, Gerhard Christofori, William R Sellers, Francesco Hofmann, Tobias Schmelzle
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61916 (2013)
The Hippo (Hpo) pathway is a novel signaling pathway that controls organ size in Drosophila and mammals and is deregulated in a variety of human cancers. It consists of a set of kinases that, through a number of phosphorylation events, inactivate YAP
Externí odkaz:
https://doaj.org/article/6648f287df874bcc8e7cfe07718ceb1a
Autor:
Saskia M. Brachmann, Simona Cotesta, Anna F. Farago, Frederic Zecri, Kun Xu, Rainer Wilcken, Toni Widmer, Peter Wessels, Hans Voshol, Andrea Vaupel, Rowan Stringer, Toshio Shimizu, Richard Sedrani, Christian Schnell, Danielle Roman, Pascal Rigollier, Johannes Ottl, Nils Ostermann, Helen Oakman, Jason Murphy, Sauveur-Michel Maira, Catherine Leblanc, Jeffrey D. Kearns, Eloísa Jiménez Núñez, Ashley Jaeger, Victoria Head, Daniel Alexander Guthy, Marc Gerspacher, Carmine Fedele, Lekshmi Dharmarajan, Ruben de Kanter, Xiaoming Cui, Xueying Chen, Heather Burks, Claudio Bomio-Confaglia, Kim S. Beyer, Louise Barys, Edwige Lorthiois, Andreas Weiss
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d58af020ff3289026b12e3df1b9a0f4
https://doi.org/10.1158/2159-8290.22541471.v1
https://doi.org/10.1158/2159-8290.22541471.v1
Autor:
Saskia M. Brachmann, Simona Cotesta, Anna F. Farago, Frederic Zecri, Kun Xu, Rainer Wilcken, Toni Widmer, Peter Wessels, Hans Voshol, Andrea Vaupel, Rowan Stringer, Toshio Shimizu, Richard Sedrani, Christian Schnell, Danielle Roman, Pascal Rigollier, Johannes Ottl, Nils Ostermann, Helen Oakman, Jason Murphy, Sauveur-Michel Maira, Catherine Leblanc, Jeffrey D. Kearns, Eloísa Jiménez Núñez, Ashley Jaeger, Victoria Head, Daniel Alexander Guthy, Marc Gerspacher, Carmine Fedele, Lekshmi Dharmarajan, Ruben de Kanter, Xiaoming Cui, Xueying Chen, Heather Burks, Claudio Bomio-Confaglia, Kim S. Beyer, Louise Barys, Edwige Lorthiois, Andreas Weiss
Covalent inhibitors of KRASG12C have shown antitumor activity against advanced/metastatic KRASG12C-mutated cancers, though resistance emerges and additional strategies are needed to improve outcomes. JDQ443 is a structurally unique covalent inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090908cffff39039ae33828ed26022f4
https://doi.org/10.1158/2159-8290.c.6549647
https://doi.org/10.1158/2159-8290.c.6549647
Autor:
Andrew X. Zhu, Nabeel Bardeesy, Ryan B. Corcoran, Dejan Juric, Alberto Bardelli, Ralph Tiedt, Diana Graus Porta, Gad Getz, A. John Iafrate, James R. Stone, David P. Ryan, Pascal Furet, Christelle Stamm, Louise Barys, Barbara Schacher-Engstler, Sabrina Baltschukat, Joseph M. Gurski, Emily E. Van Seventer, Jiaoyuan Elisabeth Sun, Laura Henderson, Stephanie Reyes, Benedetta Mussolin, Avinash Kambadakone, Vikram Deshpande, Phuong Vu, Jochen K. Lennerz, Leanne G. Ahronian, Ignaty Leshchiner, Giulia Siravegna, Leah Y. Liu, Supriya K. Saha, Lipika Goyal
Complete Data for Genetic Analysis of ctDNA and Tumor Tissue for All Samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259d7240a0c496326f717ca14ca60e36
https://doi.org/10.1158/2159-8290.22531277.v1
https://doi.org/10.1158/2159-8290.22531277.v1
Autor:
James D. Griffin, Marion Wiesmann, Sean M. McDonough, Jens U. Wuerthner, Sebastien Jeay, Martin Sattler, Erik Nelson, Kristen Cowens, Ilene Galinsky, Richard Stone, Moriko Ito, Louise Barys, Brandon Antonakos, Jing Yuan, Irene Simkin, Takaomi Sanda, Tao Ren, Atsushi Nonami, Vesselina G. Cooke, Ensar Halilovic, Ellen Weisberg
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77652698c8f5e96ead4e624b606e372c
https://doi.org/10.1158/1535-7163.22506793
https://doi.org/10.1158/1535-7163.22506793
Autor:
James D. Griffin, Marion Wiesmann, Sean M. McDonough, Jens U. Wuerthner, Sebastien Jeay, Martin Sattler, Erik Nelson, Kristen Cowens, Ilene Galinsky, Richard Stone, Moriko Ito, Louise Barys, Brandon Antonakos, Jing Yuan, Irene Simkin, Takaomi Sanda, Tao Ren, Atsushi Nonami, Vesselina G. Cooke, Ensar Halilovic, Ellen Weisberg
Supplementary Table III: AML patient samples tested with HDM2 inhibitor, CGM097: IC50 values for CGM097.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d9f78b11fd339b51f82e9097596b5f
https://doi.org/10.1158/1535-7163.22506781.v1
https://doi.org/10.1158/1535-7163.22506781.v1
Autor:
Andrew X. Zhu, Nabeel Bardeesy, Ryan B. Corcoran, Dejan Juric, Alberto Bardelli, Ralph Tiedt, Diana Graus Porta, Gad Getz, A. John Iafrate, James R. Stone, David P. Ryan, Pascal Furet, Christelle Stamm, Louise Barys, Barbara Schacher-Engstler, Sabrina Baltschukat, Joseph M. Gurski, Emily E. Van Seventer, Jiaoyuan Elisabeth Sun, Laura Henderson, Stephanie Reyes, Benedetta Mussolin, Avinash Kambadakone, Vikram Deshpande, Phuong Vu, Jochen K. Lennerz, Leanne G. Ahronian, Ignaty Leshchiner, Giulia Siravegna, Leah Y. Liu, Supriya K. Saha, Lipika Goyal
Supplementary Figure S1. Confirmation of secondary point mutation in FGFR2-ZMYM4 allele. Supplementary Figure S2. Homology between FGFR2 and FGFR3 proteins. Supplementary Figure S3. FGFR2-OPTN fusion detected in all autopsy lesions. Supplementary Fig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a948c1840bf99757e3637d1d57bc6518
https://doi.org/10.1158/2159-8290.22531280
https://doi.org/10.1158/2159-8290.22531280