Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Louise BREUIL"'
Autor:
Myriam El Biali, Louise Breuil, Matthias Jackwerth, Severin Mairinger, Maria Weber, Michael Wölfl-Duchek, Karsten Bamminger, Ivo Rausch, Lukas Nics, Marcus Hacker, Sebastian Rodrigo, Viviane Bouilleret, Markus Zeitlinger, Ekaterina Pataraia, Nicolas Tournier, Martin Bauer, Oliver Langer
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Background P-glycoprotein (P-gp) is an efflux transporter which is abundantly expressed at the blood-brain barrier (BBB) and which has been implicated in the pathophysiology of various brain diseases. The radiolabelled antiemetic drug [11C]m
Externí odkaz:
https://doaj.org/article/8f2fa73b674d4061ac07beba12949ff4
Autor:
Amélie Soyer, Sarah Leterrier, Louise Breuil, Maud Goislard, Claire Leroy, Wadad Saba, Karine Thibault, Gregory Dal Bo, Michel Bottlaender, Fabien Caillé, Sébastien Goutal, Nicolas Tournier
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
AimBuprenorphine mainly acts as an agonist of mu-opioid receptors (mu-OR). High dose buprenorphine does not cause respiratory depression and can be safely administered to elicit typical opioid effects and explore pharmacodynamics. Acute buprenorphine
Externí odkaz:
https://doaj.org/article/84f391e756a8445887e0ec19d709974d
Autor:
Solène Marie, Louise Breuil, Zacharias Chalampalakis, Laurent Becquemont, Céline Verstuyft, Anne-Lise Lecoq, Fabien Caillé, Philippe Gervais, Vincent Lebon, Claude Comtat, Michel Bottlaender, Nicolas Tournier
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113994- (2022)
Organic Anion-Transporting Polypeptides (OATPs) are known to control the liver uptake of many drugs. Non-hepatic expression of OATPs has been reported although functional importance for whole-body pharmacokinetics (WBPK) remains unknown. Glyburide is
Externí odkaz:
https://doaj.org/article/020d6170d65e48a7802fb04a277edc87
Autor:
Malvika Sardana, Louise Breuil, Sébastien Goutal, Maud Goislard, Mikhail Kondrashov, Etienne Marchal, Florent L. Besson, Christophe Dugave, Gail Wrigley, Anna C. Jonson, Bertrand Kuhnast, Magnus Schou, Nicolas Tournier, Charles S. Elmore, Fabien Caillé
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1568 (2022)
Crizotinib is a tyrosine kinase inhibitor approved for the treatment of non-small-cell lung cancer, but it is inefficient on brain metastases. Crizotinib is a substrate of the P-glycoprotein, and non-invasive nuclear imaging can be used to assess the
Externí odkaz:
https://doaj.org/article/656bb5c2d5524b698cef9f5f5f03ef39
Autor:
Louise Breuil, Nora Ziani, Sarah Leterrier, Gaëlle Hugon, Fabien Caillé, Viviane Bouilleret, Charles Truillet, Maud Goislard, Myriam El Biali, Martin Bauer, Oliver Langer, Sébastien Goutal, Nicolas Tournier
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2650 (2022)
[11C]metoclopramide PET imaging provides a sensitive and translational tool to explore P-glycoprotein (P-gp) function at the blood-brain barrier (BBB). Patients with neurological diseases are often treated with cytochrome (CYP) modulators which may i
Externí odkaz:
https://doaj.org/article/e65cab58e713472f90382c0f7d93f2af
Autor:
Louise Breuil, Sébastien Goutal, Solène Marie, Antonio Del Vecchio, Davide Audisio, Amélie Soyer, Maud Goislard, Wadad Saba, Nicolas Tournier, Fabien Caillé
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1658 (2022)
Domperidone and metoclopramide are widely prescribed antiemetic drugs with distinct neurological side effects. The impact of P-glycoprotein (P-gp)-mediated efflux at the blood–brain barrier (BBB) on brain exposure and BBB permeation was compared in
Externí odkaz:
https://doaj.org/article/4e969819b45f42e6b09eeef63d0adaeb
Autor:
Solène Marie, Irene Hernández-Lozano, Marc Le Vée, Louise Breuil, Wadad Saba, Maud Goislard, Sébastien Goutal, Charles Truillet, Oliver Langer, Olivier Fardel, Nicolas Tournier
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 392 (2022)
Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which control the hepatobiliary elimination of drugs and bile acids. 99mTc-mebrofenin is a non-metabolized substrate of transporters expressed at the different poles
Externí odkaz:
https://doaj.org/article/27ee7558c859412bb9672fe2db8e091a
Autor:
Gaëlle Hugon, Sébastien Goutal, Ambre Dauba, Louise Breuil, Benoit Larrat, Alexandra Winkeler, Anthony Novell, Nicolas Tournier
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1752 (2021)
Focused ultrasound in combination with microbubbles (FUS) provides an effective means to locally enhance the delivery of therapeutics to the brain. Translational and quantitative imaging techniques are needed to noninvasively monitor and optimize the
Externí odkaz:
https://doaj.org/article/8725d3f997024c7cada22894fcce8252
Autor:
Solène Marie, Irene Hernández-Lozano, Louise Breuil, Charles Truillet, Shuiying Hu, Alex Sparreboom, Nicolas Tournier, Oliver Langer
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 918 (2021)
Organic anion-transporting polypeptide 2B1 (OATP2B1) is co-localized with OATP1B1 and OATP1B3 in the basolateral hepatocyte membrane, where it is thought to contribute to the hepatic uptake of drugs. We characterized a novel Slco2b1(-/-) mouse model
Externí odkaz:
https://doaj.org/article/cc05e363c9f947968ceae48fa5c99dcb
Autor:
Solène Marie, Irene Hernández-Lozano, Louise Breuil, Wadad Saba, Anthony Novell, Jean-Luc Gennisson, Oliver Langer, Charles Truillet, Nicolas Tournier
Publikováno v:
Pharmaceutics, Vol 12, Iss 6, p 486 (2020)
The multidrug resistance-associated protein 2 (MRP2) mediates the biliary excretion of drugs and metabolites. [99mTc]mebrofenin may be employed as a probe for hepatic MRP2 activity because its biliary excretion is predominantly mediated by this trans
Externí odkaz:
https://doaj.org/article/a71a0ed0ba2f4ff096e080b6732a0ca2