Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Louise A. Galinet"'
Autor:
Douglas Decker, Kathleen A. Ready, Stephen Buxser, Louise A. Galinet, Steven M. Vroegop, Darryl L. Chapman, Colin J. Dunn, R.J. Brideau
Publikováno v:
International Journal of Immunopharmacology. 21:647-662
We showed previously that a 5-halo-6-phenyl-pyrimidinone, bropirimine (PNU-54461), inhibited progression of severe experimental autoimmune encephalomyelitis (EAE), an animal model of human multiple sclerosis. In the work presented here, we examined t
Autor:
Stephen Buxser, Colin J. Dunn, Douglas Decker, Steven M. Vroegop, Louise A. Galinet, Darryl L. Chapman, Kathleen A. Ready, Roger J. Brideau
Publikováno v:
International Journal of Immunopharmacology. 21:391-409
In murine severe experimental autoimmune encephalomyelitis (EAE), an animal model for the human disease multiple sclerosis (MS), we tested the efficacy of a 5-halo-6-phenyl pyrimidinone compound, bropirimine (PNU-54461). We observed that the compound
Autor:
Stephen T. Schlachter, Colin J. Dunn, Sharon K. Shields, Haiyan Wu, Megan Murphy, Danielle G. Aspar, Karen A. Richard, Richard A. Nugent, N. D. Staite, Louise A. Galinet
Publikováno v:
Journal of Medicinal Chemistry. 37:4449-4454
A study of the decomposition of the pyrazoline bisphosphonate ester 2 identified 3 as the sole bisphosphonate component. Evaluation in a delayed-type hypersensitivity granuloma model of chronic inflammation in mice (DTH-GRA) showed 3 to be a potent i
Autor:
N. D. Staite, Sharon K. Shields, Megan Murphy, Robert J. Smith, Louise A. Galinet, Colin J. Dunn, Danielle G. Aspar, Karen A. Richard, N. A. Rohloff, Richard A. Nugent, Stephen T. Schlachter
Publikováno v:
Journal of Medicinal Chemistry. 36:134-139
Vinylidenebisphosphonic acid tetraethyl ester (1) and diazo ketones 7a-1 in ether at 22 degrees C yield pyrazoline bisphosphonate tetraethyl esters 8a-1 in moderate to good yield. These compounds were evaluated in animal models of arthritis: rat adju
Autor:
Louise A. Galinet, Colin J. Dunn
Publikováno v:
Drug Development Research. 23:341-348
Combined steroid-heparin therapy has been shown to inhibit angiogenesis and tumor growth. We therefore decided to test the antiinflammatory activity of this combination therapy using “cotton pellet” and “delayed-type hypersensitivity” granulo
Autor:
Danielle G. Aspar, Louise A. Galinet, Sharon K. Shields, Colin J. Dunn, Stephen T. Schlachter, N. D. Staite, Richard A. Nugent
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(9)
Bisphosphonate ester 2 is an inhibitor of inflammation, but is devoid of antiarthritic effects. SAR studies on a series of related bisphosphonate esters resulted in compounds 6e, 6i, 6j, and 6m, which exhibited excellent inhibition of an arthritis mo
Autor:
Danielle G. Aspar, Colin J. Dunn, Katherine A. Franz, N. D. Staite, Karen A. Richard, Louise A. Galinet
Publikováno v:
Arthritis and rheumatism. 33(2)
We examined the effect of interleukin-1 (IL-1) administration on a mild and transient inflammatory response in the knees of mice injected intraarticularly with methylated bovine serum albumin (mBSA). Injection of mBSA on day 0 into nonsensitized mice