Výsledky vyhledávání - "Louise Tatton"

The impact of proliferative potential of umbilical cord-derived endothelial progenitor cells and hypoxia on vascular tubule formation in vitro

Autor: David J. P. Ferguson, Grigorios Tsaknakis, M. P. H. Tyler, Suzanne M. Watt, Jon Smythe, Thanassi Athanassopoulos, Nita Fisher, Youyi Zhang, Sarah E. Newey, Lee Carpenter, Louise Tatton, Sinead P. Forde, Sarah Hale

Revascularization of the damaged tissue is pivotal to tissue repair. Here, by bringing together two in vitro model systems, we have been able to examine (1) the ability of human umbilical vein endothelial cells (HUVEC) containing a complete hierarchy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63e076b8f2e7bbc268450439aa816d0
https://doi.org/10.1089/scd.2008.0071

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Reactive Oxygen Species and p38 Mitogen-activated Protein Kinase Mediate Tumor Necrosis Factor α-Converting Enzyme (TACE/ADAM-17) Activation in Primary Human Monocytes

Autor: Justina O. Dokpesi, Jonathan Handy, Alasdair Scott, Philip J. Hogg, Masao Takata, Louise Tatton, David O'Callaghan, Kieran P. O'Dea, Lynn M. Williams

Publikováno v: Journal of Biological Chemistry. 286:35466-35476

Tumor necrosis factor α-converting enzyme (TACE) is responsible for the shedding of cell surface TNF. Studies suggest that reactive oxygen species (ROS) mediate up-regulation of TACE activity by direct oxidization or modification of the protein. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3fa5e8bd028e9d1fb33331672a5f44
https://doi.org/10.1074/jbc.m111.277434

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Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study

Autor: Sarah Hale, Enca Martin-Rendon, Kieran Clarke, Daniel J. Stuckey, Suzanne M. Watt, Jiirgen E. Schneider, Sian E. Harding, Carolyn A. Carr, Dominic Sweeney, Damian J. Tyler, Louise Tatton, George K. Radda

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology

Basic and clinical studies have shown that bone marrow cell therapy can improve cardiac function following infarction. In experimental animals, reported stem cell-mediated changes range from no measurable improvement to the complete restoration of fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63980e9650435a10c3ebe2f9b603c548
https://doi.org/10.1152/ajpheart.00094.2008

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Caspase-Mediated Proteolysis and Activation of Protein Kinase Cδ Plays a Central Role in Neutrophil Apoptosis

Autor: Louise Tatton, Asim Khwaja

Publikováno v: Blood. 94:291-301

Neutrophils undergo constitutive apoptosis when aged ex vivo. Recent studies have indicated roles for Fas/CD95 and the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase system in this process. We have investigated the role of protein kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4401db8c0940e59adb293b85009bf35c
https://doi.org/10.1182/blood.v94.1.291.413k10_291_301

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Functional and morphological maturation of implanted neonatal cardiomyocytes as a comparator for cell therapy

Autor: Gaelle Kikonda Kanda, Hikaru Ishii, Enca Martin-Rendon, Louise Tatton, Kieran Clarke, Cesare M. Terracciano, Urszula Siedlecka, Motoki Sato, Daniel J. Stuckey, Carolyn A. Carr, Suzanne M. Watt, Sian E. Harding

Publikováno v: Stem cells and development. 19(7)

Knowledge of the rate of development of immature cardiomyocytes after implantation into a host heart is important for studies using cell therapy. To assess this functionally, we have implanted rat neonatal cardiomyocytes (NCMs) in normal and infarcte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cb8a7d3aba2861e1b1671a83ef6517
http://ora.ox.ac.uk/objects/uuid:ba31c623-7304-4d43-8d77-c4e3b8cf9bc3

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Mobilization and margination of bone marrow Gr-1high monocytes during subclinical endotoxemia predisposes the lungs toward acute injury

Autor: Kenji Wakabayashi, Louise Tatton, Justina O. Dokpesi, Nico van Rooijen, Masao Takata, Kieran P. O'Dea, Michael R. Wilson

Publikováno v: O'Dea, K P, Wilson, M, Dokpesi, J O, Wakabayashi, K, Tatton, L, van Rooijen, N & Takata, M 2009, ' Mobilization and Margination of Bone Marrow Gr-1(high) Monocytes during Subclinical Endotoxemia Predisposes the Lungs toward Acute Injury ', Journal of Immunology, vol. 182, no. 2, pp. 1155-1166 . https://doi.org/10.4049/jimmunol.182.2.1155
Journal of Immunology, 182(2), 1155-1166. American Association of Immunologists

The specialized role of mouse Gr-1high monocytes in local inflammatory reactions has been well documented, but the trafficking and responsiveness of this subset during systemic inflammation and their contribution to sepsis-related organ injury has no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbb577abb1ee6e8729b98bbf2febddb
https://pubmed.ncbi.nlm.nih.gov/19124759

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Iron particles for noninvasive monitoring of bone marrow stromal cell engraftment into, and isolation of viable engrafted donor cells from, the heart

Autor: Sarah Hale, Daniel J. Stuckey, Corinne Willmott, K Clarke, Sian E. Harding, Damian J. Tyler, Suzanne M. Watt, Paul J. Cassidy, Enca Martin-Rendon, Jürgen E. Schneider, Carolyn A. Carr, Louise Tatton, George K. Radda

Publikováno v: Stem cells (Dayton, Ohio). 24(8)

Stem cells offer a promising approach to the treatment of myocardial infarction and prevention of heart failure. We have used iron labeling of bone marrow stromal cells (BMSCs) to noninvasively track cell location in the infarcted rat heart over 16 w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a647841019355bf09fd75c51505825
http://ora.ox.ac.uk/objects/uuid:5fba88ac-836d-45e9-8688-8b19dac8d59e

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The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases

Autor: Louise Tatton, Asim Khwaja, Rajesh Chopra, Gary M. Morley

Publikováno v: The Journal of biological chemistry. 278(7)

4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]- pyrimidine (PP1) was identified as an Src-selective tyrosine kinase inhibitor and has been used extensively to investigate signaling pathways involving Src kinases, including events downstream of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82219c58bf8c532e8759bd676c9a44ac
https://pubmed.ncbi.nlm.nih.gov/12475982

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Resistance to the cytotoxic effects of tumor necrosis factor alpha can be overcome by inhibition of a FADD/caspase-dependent signaling pathway

Autor: Asim Khwaja, Louise Tatton

Publikováno v: The Journal of biological chemistry. 274(51)

Tumor necrosis factor (TNF) alpha initiates the activation of a pro-apoptotic pathway involving the recruitment of the death domain containing protein FADD and the subsequent activation of specific proteases (caspases). Many cells are resistant, howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbdd23d0436e7412784c3b4293e4c4b
https://pubmed.ncbi.nlm.nih.gov/10593992

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