Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APPswe/PS1dE9 transgenic mice: Effect of long-term treatment with paroxetine

Autor: Louise Ørum Olesen, Mithula Sivasaravanaparan, Maurizio Severino, Alicia A. Babcock, Elena V. Bouzinova, Mark J. West, Ove Wiborg, Bente Finsen

Publikováno v: Neurobiology of Disease, Vol 104, Iss , Pp 50-60 (2017)

Altered neurogenesis may influence hippocampal functions such as learning and memory in Alzheimer's disease. Selective serotonin reuptake inhibitors enhance neurogenesis and have been reported to reduce cerebral amyloidosis in both humans and transge

Externí odkaz: https://doaj.org/article/3f5e20cd7c5a44309461c26328dc1783

Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APPSWE/PS1ΔE9 Transgenic Mice

Autor: Mithula Sivasaravanaparan, Louise Ørum Olesen, Maurizio Severino, Christian Ulrich von Linstow, Kate Lykke Lambertsen, Jan Bert Gramsbergen, Jørgen Hasselstrøm, Athanasios Metaxas, Ove Wiborg, Bente Finsen

Publikováno v: Sivasaravanaparan, M, Olesen, L Ø, Severino, M, von Linstow, M C U, Lambertsen, K L, Gramsbergen, J B, Hasselstrøm, J, Metaxas, A, Wiborg, O & Finsen, B 2022, ' Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APPSWE/PS1ΔE9 Transgenic Mice ', Journal of Alzheimer's Disease, vol. 87, no. 2, pp. 685-699 . https://doi.org/10.3233/JAD-220019
Sivasaravanaparan, M, Olesen, L Ø, Severino, M, Von Linstow, C U, Lambertsen, K L, Gramsbergen, J B, Hasselstrøm, J, Metaxas, A, Wiborg, O & Finsen, B 2022, ' Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APP SWE/PS1 ΔE9 Transgenic Mice ', Journal of Alzheimer's Disease, vol. 87, no. 2, pp. 685-699 . https://doi.org/10.3233/JAD-220019

BACKGROUND: Modulation of serotonergic signaling by treatment with selective serotonin reuptake inhibitors (SSRIs) has been suggested to mitigate amyloid-β (Aβ) pathology in Alzheimer's disease, in addition to exerting an anti-depressant action.OBJ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4714a1ec2df8b56653e6f414046de850
https://pubmed.ncbi.nlm.nih.gov/35342093

Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine

Autor: Athanasios Metaxas, Kate Lykke Lambertsen, Ove Wiborg, Elena V. Bouzinova, Maurizio Severino, Louise Ørum Olesen, Alicia A. Babcock, Asif Manzoor Khan, Jan Bert Gramsbergen, Bente Finsen, Christian Ulrich von Linstow, Mithula Sivasaravanaparan

Publikováno v: Severino, M, Sivasaravanaparan, M, Olesen, L, von Linstow, C U, Metaxas, A, Bouzinova, E V, Khan, A M, Lambertsen, K L, Babcock, A A, Gramsbergen, J B, Wiborg, O & Finsen, B 2018, ' Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine ', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 4, pp. 215-223 . https://doi.org/10.1016/j.trci.2018.04.005
Severino, M, Sivasaravanaparan, M, Olesen, L Ø, von Linstow, C U, Metaxas, A, Bouzinova, E V, Khan, A M, Lambertsen, K L, Babcock, A A, Gramsbergen, J B, Wiborg, O & Finsen, B 2018, ' Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine ', Alzheimer's & Dementia, vol. 4, pp. 215-223 . https://doi.org/10.1016/j.trci.2018.04.005
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Severino, M, Sivasaravanaparan, M, Olesen, L Ø, von Linstow, C U, Metaxas, A, Bouzinova, E, Khan, A M, Lambertsen, K L, Babcock, A, Gramsbergen, J B, Wiborg, O & Finsen, B 2018, ' Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine ', Alzheimer's & Dementia: Translational Research & Clinical Interventions, vol. 4, pp. 215-223 . https://doi.org/10.1016/j.trci.2018.04.005

Introduction Treatment with selective serotonin reuptake inhibitors has been suggested to mitigate amyloid-β (Aβ) pathology in Alzheimer's disease, in addition to an antidepressant mechanism of action. Methods We investigated whether chronic treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c597ae314e2f46c7450ddd37fe67e7e
https://pure.au.dk/portal/da/publications/established-amyloid-pathology-is-unaffected-by-chronic-treatment-with-the-selective-serotonin-reuptake-inhibitor-paroxetine(3a59f02c-25d5-4d98-987c-eec9ea91a21a).html

Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APP

Autor: Louise Ørum, Olesen, Mithula, Sivasaravanaparan, Maurizio, Severino, Alicia A, Babcock, Elena V, Bouzinova, Mark J, West, Ove, Wiborg, Bente, Finsen

Publikováno v: Neurobiology of disease. 104

Altered neurogenesis may influence hippocampal functions such as learning and memory in Alzheimer's disease. Selective serotonin reuptake inhibitors enhance neurogenesis and have been reported to reduce cerebral amyloidosis in both humans and transge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8433b66c2ec7ac477a927414afe277f2
https://pubmed.ncbi.nlm.nih.gov/30717840