Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Louise, van der Weerd"'
Autor:
Ingeborg Rasing, Sabine Voigt, Emma A. Koemans, Anna M. de Kort, Thijs W. van Harten, Ellis S. van Etten, Erik W. van Zwet, Erik Stoops, Cindy Francois, H. Bea Kuiperij, Catharina J.M. Klijn, Floris H.B.M. Schreuder, Louise van der Weerd, Matthias J.P. van Osch, Marianne A.A. van Walderveen, Marcel M. Verbeek, Gisela M. Terwindt, Marieke J.H. Wermer
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Neurofilament light chain (NFL) is a biomarker for neuroaxonal damage and glial fibrillary acidic protein (GFAP) for reactive astrocytosis. Both processes occur in cerebral amyloid angiopathy (CAA), but studies investigating the p
Externí odkaz:
https://doaj.org/article/0774fef1756f448c8cf8ef7d6c1fd7b1
Autor:
Ingeborg Rasing, Sabine Voigt, Emma A. Koemans, Anna M. de Kort, Thijs W. van Harten, Ellis S. van Etten, Erik W. van Zwet, Erik Stoops, Cindy Francois, H. Bea Kuiperij, Catharina J.M. Klijn, Floris H.B.M. Schreuder, Louise van der Weerd, Matthias J.P. van Osch, Marianne A.A. van Walderveen, Marcel M. Verbeek, Gisela M. Terwindt, Marieke J.H. Wermer
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/ba7cdf1e1de44ba692105223355907bf
Autor:
Narek Manukjan, Daria Majcher, Peter Leenders, Florian Caiment, Marcel van Herwijnen, Hubert J. Smeets, Ernst Suidgeest, Louise van der Weerd, Tim Vanmierlo, Jacobus F. A. Jansen, Walter H. Backes, Robert J. van Oostenbrugge, Julie Staals, Daniel Fulton, Zubair Ahmed, W. Matthijs Blankesteijn, Sébastien Foulquier
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood–brain barrier impairments which play a key role in the development of white matter lesions. We hypothesised that cerebral hypoperfusion causes local
Externí odkaz:
https://doaj.org/article/a3555923891f4aa483f56460bea38e71
Autor:
Elsa C. Kuijper, Maurice Overzier, Ernst Suidgeest, Oleh Dzyubachyk, Cécile Maguin, Jean-Baptiste Pérot, Julien Flament, Yavuz Ariyurek, Hailiang Mei, Ronald A.M. Buijsen, Louise van der Weerd, Willeke van Roon-Mom
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106368- (2024)
In Huntington disease, cellular toxicity is particularly caused by toxic protein fragments generated from the mutant huntingtin (HTT) protein. By modifying the HTT protein, we aim to reduce proteolytic cleavage and ameliorate the consequences of muta
Externí odkaz:
https://doaj.org/article/0b4874be3df4497fb539494749184266
Autor:
Nadine Anniek van de Zande, Marjolein Bulk, Chloé Najac, Louise van der Weerd, Jeroen de Bresser, Jan Lewerenz, Itamar Ronen, Susanne Tamara de Bot
Publikováno v:
NeuroImage: Clinical, Vol 39, Iss , Pp 103450- (2023)
Introduction: Strong evidence suggests a significant role for iron accumulation in the brain in addition to the well-documented neurodegenerative aspects of Huntington’s disease (HD). The putative mechanisms by which iron is linked to the HD pathog
Externí odkaz:
https://doaj.org/article/9b3db2c2e5004b92ac3389c1fe28e6ac
Autor:
Monique R. Bernsen, Wendy McDougald, Laura Mezzanotte, Carmel M. Moran, Adriana Tavares, Louise van der Weerd
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/a32a7740752c4c308c6073a1d055556d
Autor:
Boyd Kenkhuis, Antonios Somarakis, Lorraine de Haan, Oleh Dzyubachyk, Marieke E. IJsselsteijn, Noel F. C. C. de Miranda, Boudewijn P. F. Lelieveldt, Jouke Dijkstra, Willeke M. C. van Roon-Mom, Thomas Höllt, Louise van der Weerd
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still unknown. Microglia have been identified as key players in the disease pathogenesis, and ar
Externí odkaz:
https://doaj.org/article/3f4646cb0a074c658337fbd49da6c5aa
Autor:
Boyd Kenkhuis, Antonios Somarakis, Lynn R.T. Kleindouwel, Willeke M.C. van Roon-Mom, Thomas Höllt, Louise van der Weerd
Publikováno v:
Neurobiology of Disease, Vol 167, Iss , Pp 105684- (2022)
Microglia have been identified as key players in Alzheimer's disease pathogenesis, and other neurodegenerative diseases. Iba1, and more specifically TMEM119 and P2RY12 are gaining ground as presumedly more specific microglia markers, but comprehensiv
Externí odkaz:
https://doaj.org/article/09aedfb13b844e219310394d2add8c36
Autor:
Lena H.P. Vroegindeweij, Piotr A. Wielopolski, Agnita J.W. Boon, J.H. Paul Wilson, Rob M. Verdijk, Sipeng Zheng, Sylvestre Bonnet, Lucia Bossoni, Louise van der Weerd, Juan A. Hernandez-Tamames, Janneke G. Langendonk
Publikováno v:
NeuroImage, Vol 245, Iss , Pp 118752- (2021)
Aims: Non-invasive measures of brain iron content would be of great benefit in neurodegeneration with brain iron accumulation (NBIA) to serve as a biomarker for disease progression and evaluation of iron chelation therapy. Although magnetic resonance
Externí odkaz:
https://doaj.org/article/25680c7f65bc474789a8738d5494e084
Autor:
Jorge Miguel Amaya, Ernst Suidgeest, Isabelle Sahut-Barnola, Typhanie Dumontet, Nathanaëlle Montanier, Guilhem Pagès, Cécile Keller, Louise van der Weerd, Alberto M. Pereira, Antoine Martinez, Onno C. Meijer
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Chronic exposure to high circulating levels of glucocorticoids has detrimental effects on health, including metabolic abnormalities, as exemplified in Cushing’s syndrome (CS). Magnetic resonance imaging (MRI) studies have found volumetric changes i
Externí odkaz:
https://doaj.org/article/e596fd4c771e4e17bbc71da6814d87aa