Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Louise, Thiesen"'
Autor:
Nane Griem-Krey, Stine J. Gauger, Emma K. Gowing, Louise Thiesen, Bente Frølund, Andrew N. Clarkson, Petrine Wellendorph
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113895- (2022)
Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a potential target for acute neuroprotection due to its key role in physiological and pathological glutamate signaling. The hub domain organizes the CaMKII holoenzyme into large oligomer
Externí odkaz:
https://doaj.org/article/6b670604d4114ca48d483c8678e6b24c
Autor:
Yongsong Tian, Mohamed A. Shehata, Stine Juul Gauger, Carolina Veronesi, Louise Hamborg, Louise Thiesen, Jesper Bruus-Jensen, Johanne Schlieper Royssen, Ulrike Leurs, Anne Sofie G. Larsen, Jacob Krall, Sara M.Ø. Solbak, Petrine Wellendorph, Bente Frølund
Publikováno v:
Journal of medicinal chemistry. 65(22)
Ca
Autor:
Yongsong Tian, Mohamed Shehata, Stine Gauger, Carolina Veronesi, Louise Hamborg, Louise Thiesen, Jesper Bruus-Jensen, Johanne Schlieper Royssen, Ulrike Leurs, Anne Sofie Larsen, Jacob Krall, Sara Solbak, Petrine Wellendorph, Bente Frølund
Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a brain-relevant kinase and an emerging drug target for ischemic stroke and neurodegenerative disorders. Despite various reported CaMKIIα inhibitors, their usefulness is limited by low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b93ff7e52f322bbe50e39bfc68636bd5
https://doi.org/10.26434/chemrxiv-2022-54d5q
https://doi.org/10.26434/chemrxiv-2022-54d5q
Autor:
Yongsong Tian, Mohamed A. Shehata, Stine Juul Gauger, Clarissa K. L. Ng, Sara Solbak, Louise Thiesen, Jesper Bruus-Jensen, Jacob Krall, Christoffer Bundgaard, K. Michael Gibson, Petrine Wellendorph, Bente Frølund
Publikováno v:
Journal of medicinal chemistry. 65(9)
The Ca
Publikováno v:
Journal of Neurochemistry. 149:195-210
γ-Hydroxybutyric acid (GHB) is an endogenous compound proposed to act as a neurotransmitter. Na+ -dependent, high-affinity GHB transport has long been considered important evidence supporting this hypothesis. However, the molecular identity of such
Autor:
Nina B Johansen, Maria Ek Lie, Andrew N. Clarkson, Nils Ole Dalby, Petrine Wellendorph, Emma K. Gowing, Louise Thiesen
Publikováno v:
Lie, M E, Gowing, E K, Johansen, N B, Dalby, N O, Thiesen, L, Wellendorph, P & Clarkson, A N 2019, ' GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice ', Journal of Cerebral Blood Flow and Metabolism, vol. 39, no. 1, pp. 74-88 . https://doi.org/10.1177/0271678X17744123
Ischemic stroke triggers an elevation in tonic GABA inhibition that impairs the ability of the brain to form new structural and functional cortical circuits required for recovery. This stroke-induced increase in tonic inhibition is caused by impaired
Autor:
Louise Thiesen, Bente Frølund, Anas Al-Khawaja, Maria Damgaard, Aleš Marek, Christoffer Bundgaard, Petrine Wellendorph, Anne S. Haugaard, Mònica Santiveri, Rebekka Löffler
Publikováno v:
ACS Chemical Neuroscience. 9:545-554
The betaine/γ-aminobutyric acid (GABA) transporter 1 (BGT1) is one of the four GABA transporters (GATs) involved in the termination of GABAergic neurotransmission. Although suggested to be implicated in seizure management, the exact functional impor
Autor:
Gitte M. Knudsen, Matthias M. Herth, Claus H. Jensen, Tina Bay, Rasmus P. Clausen, Szabolcs Lehel, Christoffer Bundgaard, Stine B. Vogensen, Bente Frølund, Petrine Wellendorph, Hanne D. Hansen, Louise Thiesen
Publikováno v:
ACS Chemical Neuroscience. 8:22-27
γ-Hydroxybutyric acid (GHB) is an endogenous neuroactive substance and proposed neurotransmitter with affinity for both low- and high-affinity binding sites. A radioligand with high and specific affinity toward the high-affinity GHB binding site wou
Autor:
Petrine Wellendorph, Louise Thiesen, Stine F. Pedersen, Zeinu Mussa Belew, Christoph Crocoll, Hussam Hassan Nour-Eldin, Nane Griem-Krey
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 143
The small-molecule ligand (E)-2-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[7]annulen-6-ylidene)acetic acid (NCS-382) is an analogue of γ-hydroxybutyric acid (GHB) and is widely used for probing the brain-specific GHB high-affinity binding sites. To reac
Autor:
Bente Frølund, Kenneth T. Kongstad, Barbara Rolando, Petrine Wellendorph, Louise Thiesen, Birgitte Nielsen, David E. Gloriam, Kasper Harpsøe, Anders A. Jensen, Rossella De Blasio, Jacob Krall, Karla Frydenvang, Donatella Boschi, Marco Lucio Lolli, Rebekka Löffler, Francesco Bavo, Alessandro Giraudo
Given the heterogeneity within the γ-aminobutyric acid (GABA) receptor and transporter families, a detailed insight into the pharmacology is still relatively sparse. To enable studies of the physiological roles governed by specific receptor and tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83037874b3e5f18ca333938396058973
http://hdl.handle.net/2318/1719861
http://hdl.handle.net/2318/1719861