Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Louise, Organ"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Precision cut lung slices (PCLS) have emerged as powerful experimental tools for respiratory research. Pioneering studies using mouse PCLS to visualize intrapulmonary airway contractility have been extended to pulmonary arteries and for assessment of
Externí odkaz:
https://doaj.org/article/af5f52d2455c4d8d9e7749ed6f6a6164
Autor:
Udari Eshani Perera, Louise Organ, Simon G. Royce, Chrishan S. Samuel, Habtamu B. Derseh, Sasika N. V. Dewage, Emmanuel Koumoundouros, Andrew Stent, Kenneth J. Snibson
Publikováno v:
Canadian Respiratory Journal, Vol 2023 (2023)
Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by excessive deposition of extracellular matrix in the interstitial lung parenchyma, often manifested by dyspnea and progressive loss of lung function. The role of inflammation in
Externí odkaz:
https://doaj.org/article/c4cdbb816e0647ad8668c4493bf7d4c0
Autor:
Jade Jaffar, Kate Griffiths, Sara Oveissi, Mubing Duan, Michael Foley, Ian Glaspole, Karen Symons, Louise Organ, Glen Westall
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-16 (2020)
Abstract Background CXCR4, a transmembrane-receptor located on epithelial cells that is activated by CXCL12, may have a role in IPF via migration of CXCR4+ fibrocytes to the lung. However, its expression has not been fully characterised in idiopathic
Externí odkaz:
https://doaj.org/article/1571d5984cf14f529cc9eb4518d48b90
Autor:
Habtamu B. Derseh, Kopiyawaththage U. E. Perera, Sasika N. Vithana Dewage, Andrew Stent, Emmanuel Koumoundouros, Louise Organ, Charles N. Pagel, Ken J. Snibson
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Idiopathic pulmonary fibrosis (IPF) is a progressive chronic lung disease characterized by excessive extracellular matrix (ECM) deposition in the parenchyma of the lung. Accompanying the fibrotic remodeling, dysregulated angiogenesis has been observe
Externí odkaz:
https://doaj.org/article/bd205fb8776e4e3fa911e8440c80dcab
Autor:
Habtamu B. Derseh, Sasika N. Vithana Dewage, Kopiyawaththage U. E. Perera, Charles N. Pagel, Emmanuel Koumoundouros, Louise Organ, Ken J. Snibson
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with limited therapeutic options and poor prognosis. IPF has been associated with aberrant vascular remodelling, however the role of vascular remodelling in pulmonary
Externí odkaz:
https://doaj.org/article/18bd2ab7a74e400796b59f1eeaf6c5b4
Autor:
Udari E. Perera, Louise Organ, Sasika N. V. Dewage, Habtamu B. Derseh, Andrew Stent, Kenneth J. Snibson
Publikováno v:
Canadian Respiratory Journal, Vol 2021 (2021)
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease, characterized by progressive damage to the lung tissues. Apoptosis and endoplasmic reticulum stress (ER stress) in type II alveolar epithelial cells (AECs) and lung macrophages
Externí odkaz:
https://doaj.org/article/908789700f3c4800baa20f46f7156b29
Autor:
Louise Organ
Publikováno v:
Breathe, Vol 15, Iss 4, Pp 343-345 (2019)
Externí odkaz:
https://doaj.org/article/99bd1dd264fc488c823c1a4e5d1bbb8a
Autor:
Charles N. Pagel, Emmanuel Koumoundouros, Kenneth J. Snibson, Louise Organ, Sasika N. Vithana Dewage, Habtamu B Derseh, Udari Eshani Perera
Publikováno v:
Experimental Lung Research. 46:409-419
Background Although IPF is described traditionally as a disease affecting lung parenchyma, there is renewed interest in the alterations in the structure and function of the small airways in both IPF patients, and animal models of pulmonary fibrosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f900f1b3ae2cfe0eb72c86c35dab76
https://doi.org/10.1080/01902148.2020.1834015
https://doi.org/10.1080/01902148.2020.1834015
Autor:
Natasja Stæhr Gudmann, Richard P. Marshall, Jeni Luckett, Rebecca F. Rogers, Robert J. Slack, Simon J. F. Macdonald, Diana Julie Leeming, Rachel C. Chambers, Joelle Le, Pauline T. Lukey, Anthony Habgood, Paul F. Mercer, Rachel A. Burgoyne, Ben S. Barksby, Lloyd I. Bibby, Yim Man, Maryam Hafeji, Andrew J. Fisher, David J. Flint, Toby M. Maher, Louise Organ, Susan Pyne, Lee A. Borthwick, James A. Roper, Valerie S. Morrison, Alison E. John, Giovanni Vitulli, Rebecca H. Graves, Rochelle C. Edwards-Pritchard, R. Gisli Jenkins, John Barrett, Josie Morrell, K. Tao Pun, Elaine Gower, Rory Barnes, Ellen J. Forty, Chitra Joseph
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The αvβ6 integrin plays a key role in the activation of transforming growth factor-β (TGFβ), a pro-fibrotic mediator that is pivotal to the development of idiopathic pulmonary fibrosis (IPF). We identified a selective small molecule αvβ6 RGD-mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b4959cf67302e9783a88dddd530b0b
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
Autor:
Charles N. Pagel, Louise Organ, Kopiyawaththage U. E. Perera, Emmanuel Koumoundouros, Kenneth J. Snibson, Sasika N. Vithana Dewage, Habtamu B Derseh
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with limited therapeutic options and poor prognosis. IPF has been associated with aberrant vascular remodelling, however the role of vascular remodelling in pulmonary fibrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e9e0c07ee00abf209a71c2b2559df4
https://doaj.org/article/18bd2ab7a74e400796b59f1eeaf6c5b4
https://doaj.org/article/18bd2ab7a74e400796b59f1eeaf6c5b4