Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health

Autor: Thi Phuong Nam Bui, Louise Mannerås-Holm, Robert Puschmann, Hao Wu, Antonio Dario Troise, Bart Nijsse, Sjef Boeren, Fredrik Bäckhed, Dorothea Fiedler, Willem M. deVos

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Here, the authors report an anaerobic metabolic pathway from the dominant gut butyrogen Anaerostipes, showing several strains of this genus to be capable of producing propionate from dietary myo-inositol that associates with reduced fasting-glucose l

Externí odkaz: https://doaj.org/article/0a0896c3fef945c5b35c436a101db9ab

Host–microbiota interaction induces bi-phasic inflammation and glucose intolerance in mice

Autor: Antonio Molinaro, Robert Caesar, Louise Mannerås Holm, Valentina Tremaroli, Patrice D. Cani, Fredrik Bäckhed

Publikováno v: Molecular Metabolism, Vol 6, Iss 11, Pp 1371-1380 (2017)

Objective: Gut microbiota modulates adiposity and glucose metabolism in humans and mice. Here we investigated how colonization of germ-free (GF) mice affects kinetics of adiposity and glucose metabolism. Methods: Adiposity and glucose metabolism were

Externí odkaz: https://doaj.org/article/81368eccf9244e549620d9d90f6602e3

Electrical vs manual acupuncture stimulation in a rat model of polycystic ovary syndrome: different effects on muscle and fat tissue insulin signaling.

Autor: Julia Johansson, Louise Mannerås-Holm, Ruijin Shao, AnneLiese Olsson, Malin Lönn, Håkan Billig, Elisabet Stener-Victorin

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e54357 (2013)

In rats with dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS), repeated low-frequency electrical stimulation of acupuncture needles restores whole-body insulin sensitivity measured by euglycemic hyperinsulinemic clamp. We hypothesiz

Externí odkaz: https://doaj.org/article/1feef1a68d6b43fca6d5e63ad83aeeec

Diacylglycerol kinase α deficiency alters inflammation markers in adipose tissue in response to a high-fat diet

Autor: Alexander V. Chibalin, Louise Mannerås-Holm, Marie Björnholm, Juleen R. Zierath, Emmani B.M. Nascimento

Publikováno v: Journal of Lipid Research, Vol 59, Iss 2, Pp 273-282 (2018)

Conversion of diacylglycerol to phosphatidic acid is mediated by diacylglycerol kinases (DGKs), with DGKα specifically linked to adaptive immune responses. We determined the role of DGKα in obesity and inflammatory responses to a high-fat diet (HFD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb5dd8cb0b9ae54e7c0e5560939e481
https://doi.org/10.1194/jlr.m079517

The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism

Autor: Christina N. Heiss, Randy J. Seeley, Ying Shiuan Lee, Fredrik Bäckhed, Anna Håkansson Gladh, Daniel J. Drucker, Louise Mannerås-Holm, Julia Serrano-Lobo, Louise E. Olofsson

Publikováno v: Heiss, C N, Mannerås-Holm, L, Lee, Y S, Serrano-Lobo, J, Håkansson Gladh, A, Seeley, R J, Drucker, D J, Bäckhed, F & Olofsson, L E 2021, ' The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism ', Cell Reports, vol. 35, no. 8, 109163 . https://doi.org/10.1016/j.celrep.2021.109163

Mice lacking a microbiota are protected from diet-induced obesity. Previous studies have shown that feeding a Western diet causes hypothalamic inflammation, which in turn can lead to leptin resistance and weight gain. Here, we show that wild-type (WT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1246c48efc4ba88cddca0f7c9a69b5f7
https://doi.org/10.1016/j.celrep.2021.109163