Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Louise, Delsing"'
Enhanced xeno-free differentiation of hiPSC-derived astroglia applied in a blood–brain barrier model
Publikováno v:
Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Human induced pluripotent stem cells (hiPSC) hold great promise for use in cell therapy applications and for improved in vitro models of human disease. So far, most hiPSC differentiation protocols to astroglia use undefined, anima
Externí odkaz:
https://doaj.org/article/17a5faa4b8e24315a3a59072cff0d220
Autor:
Anders Lundin, Louise Delsing, Maryam Clausen, Piero Ricchiuto, José Sanchez, Alan Sabirsh, Mei Ding, Jane Synnergren, Henrik Zetterberg, Gabriella Brolén, Ryan Hicks, Anna Herland, Anna Falk
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 1030-1045 (2018)
Summary: In vivo studies of human brain cellular function face challenging ethical and practical difficulties. Animal models are typically used but display distinct cellular differences. One specific example is astrocytes, recently recognized for con
Externí odkaz:
https://doaj.org/article/744833d558064ed48a43910333ebf5f2
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177181 (2017)
The RNA-binding and -processing protein TAR DNA-binding protein 43 (TDP-43) is heavily linked to the underlying causes and pathology of neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration. In these d
Externí odkaz:
https://doaj.org/article/254ae68e506d4436b553113c9b2e51cc
Publikováno v:
Molecular and Cellular Neuroscience. 107:103533
The blood-brain barrier (BBB) constitutes the interface between the blood and the brain tissue. Its primary function is to maintain the tightly controlled microenvironment of the brain. Models of the BBB are useful for studying the development and ma
Autor:
Damian C. Crowther, Ryan Hicks, Lorna Ewart, Nicola Colclough, Kristin M. Fabre, Louise Delsing
Publikováno v:
Advanced drug delivery reviews. 140
Microphysiological systems (MPS) may be able to provide the pharmaceutical industry models that can reflect human physiological responses to improve drug discovery and translational outcomes. With lack of efficacy being the primary cause for drug att
Autor:
Lisbeth, Kristensson, Anders, Lundin, David, Gustafsson, Jan, Fryklund, Tomas, Fex, Louise, Delsing, Erik, Ryberg
Publikováno v:
Neuroscience letters. 681
Plasminogen binding inhibitors (PBIs) reduce the risk of bleeding in hemorrhagic conditions. However, generic PBIs are also associated with an increased risk of seizures, an adverse effect linked to unwanted activities towards inhibitory neuronal rec
Autor:
Louise, Delsing, Pierre, Dönnes, José, Sánchez, Maryam, Clausen, Dimitrios, Voulgaris, Anna, Falk, Anna, Herland, Gabriella, Brolén, Henrik, Zetterberg, Ryan, Hicks, Jane, Synnergren
Publikováno v:
Stem cells (Dayton, Ohio). 36(12)
Cell-based models of the blood-brain barrier (BBB) are important for increasing the knowledge of BBB formation, degradation and brain exposure of drug substances. Human models are preferred over animal models because of interspecies differences in BB
Autor:
Anna Herland, Alan Sabirsh, Mei Ding, Maryam Clausen, Jane Synnergren, Ryan Hicks, Louise Delsing, Piero Ricchiuto, Anders Lundin, Jose Miguel Sanchez, Anna Falk, Gabriella Brolén, Henrik Zetterberg
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 1030-1045 (2018)
Stem Cell Reports
Stem Cell Reports
Summary In vivo studies of human brain cellular function face challenging ethical and practical difficulties. Animal models are typically used but display distinct cellular differences. One specific example is astrocytes, recently recognized for cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8584cc3328e7aacc7f6b6af9dfa2bbaa
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14757
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14757
Autor:
Lisbeth Kristensson, Erik Ryberg, Anders Lundin, Tomas Fex, Jan Fryklund, Louise Delsing, David Gustafsson
Plasminogen binding inhibitors (PBIs) reduce the risk of bleeding in hemorrhagic conditions. However, generic PBIs are also associated with an increased risk of seizures, an adverse effect linked to unwanted activities towards inhibitory neuronal rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e987f2b8a085a5d3580804a7d3c76a5
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-15263
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-15263
Autor:
Shorena Janelidze, Anders Wimo, Henrik Zetterberg, Maria Eriksdotter, Lena Kilander, Niklas Mattsson, Bengt Winblad, Oskar Hansson, Katarina Nägga, Ryan Hicks, Jane Synnergren, Kaj Blennow, Louise Delsing, Tobias Skillbäck
Publikováno v:
Neurobiology of Aging
A connection between dementias and blood-brain barrier (BBB) dysfunction has been suggested, but previous studies have yielded conflicting results. We examined cerebrospinal fluid (CSF)/serum albumin ratio in a large cohort of patients diagnosed with