Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction

Autor: Martin Houde, Adel Schwertani, Hanène Touil, Louisane Desbiens, Otman Sarrhini, Roger Lecomte, Martin Lepage, Hugo Gagnon, Shinji Takai, Gunnar Pejler, Danielle Jacques, Fernand Gobeil, Robert Day, Pedro D’Orléans-Juste

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Chymase, a mast cell serine protease involved in the generation of multiple cardiovascular factors, such as angiotensin II and endothelin-1 (ET-1), is elevated and participates in tissue degeneration after permanent myocardial infarction (PMI). Anest

Externí odkaz: https://doaj.org/article/7ecc202a5ad84f19a487e143256394bc

Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4–Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1

Autor: Louis Gendron, Gunnar Pejler, Louisane Desbiens, Catherine Lapointe, Denis Gris, Marjan Gharagozloo, Pedro D’Orléans-Juste, Laurence Vincent

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 370:437-446

Multiple sclerosis is a neurodegenerative disease affecting predominantly female patients between 20 and 45 years of age. We previously reported the significant contribution of mouse mast cell protease 4 (mMCP-4) in the synthesis of endothelin-1 (ET-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017a364d6f6e183895d33e371826fe71
https://doi.org/10.1124/jpet.118.256016

25Years of endothelin research: the next generation

Autor: Julia Straube, Matthias Barton, Louisane Desbiens, Rheure A Lopes, Noriaki Emoto, Susi Heiden, Adviye Ergul, Joseph A. Cacioppo, Thomas Leurgans, Masashi Yanagisawa, Danielle Kamato, Raphael Wurm, Nicolas Vignon-Zellweger, Rebecca Moorhouse

Publikováno v: Emoto, N, Vignon-Zellweger, N, Lopes, R A M, Cacioppo, J, Desbiens, L, Kamato, D, Leurgans, T, Moorhouse, R, Straube, J, Wurm, R, Heiden, S, Ergul, A, Yanagisawa, M & Barton, M 2014, ' 25 Years of endothelin research : The next generation ', Life Sciences, vol. 118, no. 2, pp. 77-86 . https://doi.org/10.1016/j.lfs.2014.07.035

In the past three decades, endothelin and endothelin receptor antagonists have received great scientific and clinical interest, leading to the publication of more than 27,000 scientific articles since its discovery. The Thirteenth International Confe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5261fa08d7ce913562f52b7945364f32

Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis

Autor: Pedro D'Orléans-Juste, Louisane Desbiens, Denis Gris, Shaimaa Mahmoud, Catherine Lapointe, Gunnar Pejler, Marjan Gharagozloo

Publikováno v: Mediators of Inflammation
Mediators of Inflammation, Vol 2016 (2016)

Experimental autoimmune encephalomyelitis (EAE) is a mouse model that reproduces cardinal signs of clinical, histopathological, and immunological features found in Multiple Sclerosis (MS). Mast cells are suggested to be involved in the main inflammat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c03f53ef8e8654e4d93d2f8d1b84502
https://pubmed.ncbi.nlm.nih.gov/27610007

Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase

Autor: Hugo Gagnon, Julie Labonté, Ghassan Bkaily, Tanya M. Laidlaw, Roxane Desjardins, Daisuke Yamamoto, Shinji Takai, Pedro D'Orléans-Juste, Walid Semaan, Gunnar Pejler, Martin Houde, Adel Schwertani, Robert Day, Christine Levesque, Louisane Desbiens

Publikováno v: Biochemical pharmacology. 94(2)

Important structural differences imply that human and mouse mast cell chymases may differ with respect to their enzymatic properties. We compared in this study the catalytic efficiencies of recombinant human chymase (rCMA1) and its functional murine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee77b6d60e7e0274a241847bf9580cd6
https://pubmed.ncbi.nlm.nih.gov/25667044