Výsledky vyhledávání - "Louisa Wirthlin"

Akademický článek

Differentially expressed microRNAs in chondrocytes from distinct regions of developing human cartilage.

Autor: Audrey McAlinden, Nobish Varghese, Louisa Wirthlin, Li-Wei Chang

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75012 (2013)

There is compelling in vivo evidence from reports on human genetic mutations and transgenic mice that some microRNAs (miRNAs) play an important functional role in regulating skeletal development and growth. A number of published in vitro studies also

Externí odkaz: https://doaj.org/article/ab152aa1e57c48898994f929f955fa62

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Changes in type II procollagen isoform expression during chondrogenesis by disruption of an alternative 5′ splice site within Col2a1 exon 2

Autor: Louisa Wirthlin, Thomas M. Hering, Audrey McAlinden, Soumya Ravindran

Publikováno v: Matrix Biology. 36:51-63

This study describes a new mechanism controlling the production of alternatively spliced isoforms of type II procollagen (Col2a1) in vivo. During chondrogenesis, precursor chondrocytes predominantly produce isoforms containing alternatively spliced e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ad3b5d85150686c465b2cf8f7366cb
https://doi.org/10.1016/j.matbio.2014.04.004

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Disruption of the developmentally-regulated Col2a1 pre-mRNA alternative splicing switch in a transgenic knock-in mouse model

Autor: Russell J. Fernandes, Louisa Wirthlin, Renate M. Lewis, Soumya Ravindran, Geoffrey Traeger, Audrey McAlinden

Publikováno v: Matrix Biology. 31:214-226

The present study describes the generation of a knock-in mouse model to address the role of type II procollagen (Col2a1) alternative splicing in skeletal development and maintenance. Alternative splicing of Col2a1 precursor mRNA is a developmentally-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5043e012b23a1159b7e4c0fbf6aab85
https://doi.org/10.1016/j.matbio.2011.12.004

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Widespread Nonhematopoietic Tissue Distribution by Transplanted Human Progenitor Cells with High Aldehyde Dehydrogenase Activity

Autor: Sarah A. Hohm, David A. Hess, William C. Eades, Louisa Wirthlin, Jan A. Nolta, Timothy P. Craft, Michael H. Creer, Mark S. Sands, Ping Zhou

Publikováno v: Stem Cells. 26:611-620

Transplanted adult progenitor cells distribute to peripheral organs and can promote endogenous cellular repair in damaged tissues. However, development of cell-based regenerative therapies has been hindered by the lack of preclinical models to effici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd47c6b2be3dfd9e0a49f5e975a36811
https://doi.org/10.1634/stemcells.2007-0429

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Human Progenitor Cells Rapidly Mobilized by AMD3100 Repopulate NOD/SCID Mice with Increased Frequency in Comparison to Cells from the Same Donor Mobilized by Granulocyte Colony Stimulating Factor

Autor: John F. DiPersio, Laura Todt, Louisa Wirthlin, Ryan Lahey, Steven M. Devine, Jesper Bonde, David A. Hess, Timothy P. Craft, Sarah A. Hohm, Jan A. Nolta

Publikováno v: Biology of Blood and Marrow Transplantation. 13(4):398-411

AMD3100 inhibits the interaction between SDF-1 and CXCR4, and rapidly mobilizes hematopoietic progenitors for clinical transplantation. However, the repopulating function of human cells mobilized with AMD3100 has not been characterized in comparison

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106d251e76be9424b5b2fac841a3d064

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In Vivo Distribution of Human Adipose-Derived Mesenchymal Stem Cells in Novel Xenotransplantation Models

Autor: J. Chris Eagon, Todd E. Meyerrose, Mark S. Sands, Louisa Wirthlin, Marc A. Hedrick, Leonard D. Shultz, Daniel A. De Ugarte, A. Alex Hofling, Phillip E. Herrbrich, Jan A. Nolta, Taylor D. Cordonnier

Publikováno v: Stem Cells. 25:220-227

The potential for human adipose-derived mesenchymal stem cells (AMSC) to traffic into various tissue compartments was examined using three murine xenotransplantation models: nonobese diabetic/severe combined immunodeficient (NOD/SCID), nude/NOD/SCID,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c3e41a577ebfe51a7c30273ae92895
https://doi.org/10.1634/stemcells.2006-0243

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Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells

Autor: Michael H. Creer, David A. Hess, Sarah A. Hohm, Timothy P. Craft, Phillip E. Herrbrich, Ryan Lahey, Jan A. Nolta, Louisa Wirthlin, William C. Eades

Publikováno v: Blood. 107:2162-2169

The development of novel cell-based therapies requires understanding of distinct human hematopoietic stem and progenitor cell populations. We recently isolated reconstituting hematopoietic stem cells (HSCs) by lineage depletion and purification based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9cc6c1d7c6cf63902eb1f360b368e0
https://doi.org/10.1182/blood-2005-06-2284

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Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity

Autor: Phillip E. Herrbrich, Timothy P. Craft, Todd E. Meyerrose, Michael H. Creer, David A. Hess, Jan A. Nolta, Louisa Wirthlin

Publikováno v: Blood. 104:1648-1655

Human hematopoietic stem cells (HSCs) are commonly purified by the expression of cell surface markers such as CD34. Because cell phenotype can be altered by cell cycle progression or ex vivo culture, purification on the basis of conserved stem cell f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724b02f3780f265c8f4ab3db1744c844
https://doi.org/10.1182/blood-2004-02-0448

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Glial cell line-derived neurotrophic factor-enriched bridging transplants promote propriospinal axonal regeneration and enhance myelination after spinal cord injury

Autor: Huayin Li, Xiaobin Lu, Xiao Ming Xu, Ping Yan, Christopher Iannotti, Louisa Wirthlin

Publikováno v: Experimental Neurology. 183:379-393

Glial cell line-derived neurotrophic factor (GDNF), a distant member of the transforming growth factor-beta (TGF-beta) family, is widely expressed in the developing and adult central nervous system (CNS). At present, limited information is available

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac5faa7e5f375bc892e7199901276f1
https://doi.org/10.1016/s0014-4886(03)00188-2

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