Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Louisa S Chard"'
Autor:
Jun Wang, Peng Liu, Nicholas Lemoine, Yaohe Wang, Louisa S Chard Dunmall, Carmela Di Gioia, Claude Chelala, Renato Brito Baleeiro, Ai Nagano, Lauren Cutmore, Lydon Wainaina Nyambura, Peter Walden
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Background Triple-negative breast cancer (TNBC) corresponds to approximately 20% of all breast tumors, with a high propensity for metastasis and a poor prognosis. Because TNBC displays a high mutational load compared with other breast cancer types, a
Externí odkaz:
https://doaj.org/article/4a364f55984e4ee2890cd336874dee1d
Autor:
Yangyang Jia, Yanru Wang, Louisa S Chard Dunmall, Nicholas R. Lemoine, Pengju Wang, Yaohe Wang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cancer immunotherapy (CIT) has emerged as an exciting new pillar of cancer treatment. Although benefits have been achieved in individual patients, the overall response rate is still not satisfactory. To address this, an ideal preclinical animal model
Externí odkaz:
https://doaj.org/article/41c87dac90124c76b9c6c211a853f0dd
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Many energy metabolism pathways exist in cancer, including glycolysis, amino acid metabolism, fatty acid oxidation, and mitochondrial respiration. Tumor cells mainly generate energy through glycolysis to maintain growth and biosynthesis of tumor cell
Externí odkaz:
https://doaj.org/article/b2f4d10882ca46df85686eeeb6035f60
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 5 (2022)
Tumor cells manipulate the local environment in which they grow, creating a tumor microenvironment (TME) that promotes tumor survival and metastasis. The TME is an extremely complex environment rich in immunosuppressive cells and cytokines. Various m
Externí odkaz:
https://doaj.org/article/ee9e34c281bd47568d1127c5cd2cb33e
Autor:
Jahangir Ahmed, Ming Yuan, Zhongxian Zhang, Nicholas Lemoine, Yaohe Wang, Giulia Marelli, Louisa S Chard Dunmall, Carmela Di Gioia, Jinxin Miao, Zhenguo Cheng, Rathi Gangeswaran
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Background Pancreatic cancer remains one of the most lethal cancers and is refractory to immunotherapeutic interventions. Oncolytic viruses are a promising new treatment option, but current platforms demonstrate limited efficacy, especially for inacc
Externí odkaz:
https://doaj.org/article/24cba0290a804cf7b8b7cccfb572b712
Autor:
Louisa S Chard, Anwen Howells, Yuenan Li, Haoze Li, Shuangshuang Lu, Dongling Gao, Pengju Wang, Yongchao Chu, Ghassan Alusi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
BackgroundLocal recurrence and remote metastasis are major challenges to overcome in order to improve the survival of patients with cancer after surgery. Oncolytic viruses are a particularly attractive option for prevention of postsurgical disease as
Externí odkaz:
https://doaj.org/article/dfbd090b995442cbb719cb8ef1b6cea3
Autor:
Guozhong Jiang, Zhizhong Wang, Zhenguo Cheng, Weiwei Wang, Shuangshuang Lu, Zifang Zhang, Chinedu A. Anene, Faraz Khan, Yue Chen, Emma Bailey, Huisha Xu, Yunshu Dong, Peinan Chen, Zhongxian Zhang, Dongling Gao, Zhimin Wang, Jinxin Miao, Xia Xue, Pengju Wang, Lirong Zhang, Rathi Gangeswaran, Peng Liu, Louisa S. Chard Dunmall, Junkuo Li, Yongjun Guo, Jianzeng Dong, Nicholas R. Lemoine, Wencai Li, Jun Wang, Yaohe Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Esophageal squamous cell carcinoma (ESCC) is highly heterogeneous. Our understanding of full molecular and immune landscape of ESCC remains limited, hindering the development of personalised therapeutic strategies. To address this, we perfor
Externí odkaz:
https://doaj.org/article/c3c0976adb9a46179840a933958f546b
Autor:
Pengju Wang, Xiaozhu Li, Jiwei Wang, Dongling Gao, Yuenan Li, Haoze Li, Yongchao Chu, Zhongxian Zhang, Hongtao Liu, Guozhong Jiang, Zhenguo Cheng, Shengdian Wang, Jianzeng Dong, Baisui Feng, Louisa S Chard, Nicholas R Lemoine, Yaohe Wang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The originally published version of this Article contained errors in Figure 4. In panel b, the square and diamond labels associated with the uppermost survival curve were incorrectly displayed as ‘n’ and ‘u’, respectively. These errors have n
Externí odkaz:
https://doaj.org/article/480ad26356494b4ba55bf572179933af
Autor:
Ming Yuan, Xuefei Gao, Louisa S Chard, Zarah Ali, Jahangir Ahmed, Yunqing Li, Pentao Liu, Nick R Lemoine, Yaohe Wang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
The current method for creation of vaccinia virus (VACV) vectors involves using a selection and purification marker, however inclusion of a gene without therapeutic value in the resulting vector is not desirable for clinical use. The Cre-LoxP system
Externí odkaz:
https://doaj.org/article/877a270d03ca43068bd8606fc497f5da
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