Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Louisa MCROBERT"'
Autor:
Louisa McRobert, Cathy J Taylor, Wensheng Deng, Quinton L Fivelman, Ross M Cummings, Spencer D Polley, Oliver Billker, David A Baker
Publikováno v:
PLoS Biology, Vol 6, Iss 6, p e139 (2008)
Malaria parasite transmission requires differentiation of male and female gametocytes into gametes within a mosquito following a blood meal. A mosquito-derived molecule, xanthurenic acid (XA), can trigger gametogenesis, but the signalling events cont
Externí odkaz:
https://doaj.org/article/1b434b20175d41168a2c7a87c04c88a9
Autor:
Louisa McRobert, Anthony A. Holder, Audrey Sicard, Anton R. Dluzewski, Christine S. Hopp, Munira Grainger, Helen M. Taylor, David A. Baker
Publikováno v:
Eukaryotic Cell. 9:37-45
A role for the Plasmodium falciparum cyclic GMP (cGMP)-dependent protein kinase (PfPKG) in gametogenesis in the malaria parasite was elucidated previously. In the present study we examined the role of PfPKG in the asexual blood-stage of the parasite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4c2c2a7707c338d180638c809c3ff5
https://doi.org/10.1128/ec.00186-09
https://doi.org/10.1128/ec.00186-09
Publikováno v:
Molecular Microbiology
Phosphodiesterase (PDE) and guanylyl cyclase (GC) enzymes are key components of the cGMP signalling pathway and are encoded in the genome of Plasmodium falciparum. Here we investigate the role of specific GC and PDE isoforms in gamete formation--a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b329d6350036dd7341a72c39fa1a3df0
http://europepmc.org/articles/PMC2615252
http://europepmc.org/articles/PMC2615252
Autor:
Cathy J. Taylor, Quinton L. Fivelman, Sarah Sharp, Colin J. Sutherland, Louisa McRobert, Claire A. Swales, Maha Saeed, David A. Baker
Publikováno v:
Molecular and Biochemical Parasitology. 154:119-123
The sexual stages of the Plasmodium falciparum life cycle are attractive targets for vaccines and transmission blocking drugs. Difficulties in culturing and obtaining large amounts of sexual stage P. falciparum parasites, particularly early stages, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1e66ca10eeaf34f25c8820a4e2be13
https://doi.org/10.1016/j.molbiopara.2007.04.008
https://doi.org/10.1016/j.molbiopara.2007.04.008
Publikováno v:
Proceedings of the National Academy of Sciences. 103:6706-6711
Centromeres are the chromosomal loci that facilitate segregation, and, in most eukaryotes, they encompass extensive regions of genomic DNA. Topoisomerase-II has been identified as a crucial regulator of segregation in a wide range of organisms and ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d30ffceeff8f2c4987b3a7f3bc85ef
https://doi.org/10.1073/pnas.0510363103
https://doi.org/10.1073/pnas.0510363103
Publikováno v:
Experimental Parasitology. 111:178-181
The shikimate pathway for aromatic biosynthesis presents a target for antimalarial drug development as this pathway is absent from animals. This study extends previous work on inhibitors of the shikimate pathway, by examining their interaction with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40fc1a3f7e96e081d731970163ef179
https://doi.org/10.1016/j.exppara.2005.07.002
https://doi.org/10.1016/j.exppara.2005.07.002
Publikováno v:
Trends in Parasitology. 20:99-102
Among the surface-exposed antigens of the malaria parasite, those with known essential functions that can be disrupted by antibodies represent the most promising candidates for development as malaria vaccines. Two recombinant protein subunits of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c955e94aa411aab1d6cc6c0d10cbddf8
https://doi.org/10.1016/j.pt.2003.12.003
https://doi.org/10.1016/j.pt.2003.12.003
Autor:
Louisa McRobert, Glenn A. McConkey
Publikováno v:
Molecular and Biochemical Parasitology. 119:273-278
RNA interference (RNAi) causes degradation of targeted endogenous RNA in many diverse organisms. Erythrocyte-infecting stages of the malaria parasite Plasmodium falciparum were treated with double-stranded RNA (dsRNA) encoding a segment of the gene e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac62fa666d20721e0fb14b1900613fd2
https://doi.org/10.1016/s0166-6851(01)00429-7
https://doi.org/10.1016/s0166-6851(01)00429-7
Autor:
Marie D. PARKER, Ralph J. HYDE, Sylvia Y. M. YAO, Louisa MCROBERT, Carol E. CASS, James D. YOUNG, Glenn A. MCCONKEY, Stephen A. BALDWIN
Publikováno v:
Biochemical Journal. 349:67-75
Plasmodium, the aetiologic agent of malaria, cannot synthesize purines de novo, and hence depends upon salvage from the host. Here we describe the molecular cloning and functional expression in Xenopus oocytes of the first purine transporter to be id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7312280eddb66b8e268f43d4aee96f12
https://doi.org/10.1042/bj3490067
https://doi.org/10.1042/bj3490067
Autor:
Quinton L. Fivelman, Cathy J. Taylor, Helen M. Taylor, Wensheng Deng, David Baker, Munira Grainger, Oliver Billker, Spencer D. Polley, Louisa McRobert, Anthony A. Holder, Audrey Sicard, Robert W. Moon
Publikováno v:
BMC Pharmacology
The life cycle of the malaria parasite Plasmodium is complex with distinct phases occurring in the human host and the mosquito vector. Proliferation of asexual parasites within blood cells leads to pathology whereas a distinct sexual stage is require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6518883c65abab7c659bc55fb9fa669
https://doi.org/10.1186/1471-2210-9-s1-s2
https://doi.org/10.1186/1471-2210-9-s1-s2