Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Louisa J. Phillipson"'
Autor:
Christopher J. Burns, Ian P. Wicks, Patrizia M Novello, David J. Segal, Devi Ngo, Helene Jousset, Cynthia Louis, Louisa J. Phillipson, Jacinta Hansen, Kate E. Lawlor, Damian B D'Silva
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 71(1)
Objective The production of class-switched high-affinity autoantibodies derived from organized germinal centers (GCs) is a hallmark of many autoimmune inflammatory diseases, including rheumatoid arthritis (RA). TANK-binding kinase 1 (TBK-1) is a seri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dcd3f36c74b0b0a5e46a61fe883e87
https://pubmed.ncbi.nlm.nih.gov/30009417
https://pubmed.ncbi.nlm.nih.gov/30009417
Autor:
Mark A. Guthridge, Andrew H. Wei, David J. Segal, Tracy L. Nero, Melanie de Silva, Michael W. Parker, Christopher J. Burns, Soo San Wan, Louisa J. Phillipson
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:6280-6296
The serine-threonine kinase CDK9 is a target of emerging interest for the development of anti-cancer drugs. There are multiple lines of evidence linking CDK9 activity to cancer, including the essential role this kinase plays in transcriptional regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320f161d7b5b20cab63cb0f5d609ec23
https://doi.org/10.1016/j.bmc.2015.08.035
https://doi.org/10.1016/j.bmc.2015.08.035
Autor:
Louisa J. Phillipson, Matthew E. Ritchie, Lily Lee, Bhupinder Pal, François Vaillant, Gordon K. Smyth, GB Mann, Delphine Merino, Christopher J. Burns, JE Visvader, GJ Lindeman, Michael Christie, Kelsey Breslin
Publikováno v:
Cancer Research. 73:P2-09
Background: Impairment of apoptosis is a hallmark of cancer and can result in resistance to therapy. Over-expression of the pro-survival protein BCL-2 is common in breast cancer, with elevated levels found in approximately 85% of luminal tumors. Alth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::151ef2e1c7d0079e86c2356f3071401b
https://doi.org/10.1158/0008-5472.sabcs13-p2-09-01
https://doi.org/10.1158/0008-5472.sabcs13-p2-09-01
Autor:
G. Bruce Mann, Bhupinder Pal, Gordon K. Smyth, Matthew E. Ritchie, Lily Lee, Kelsey Breslin, Delphine Merino, Louisa J. Phillipson, Geoffrey J. Lindeman, Christopher J. Burns, Michael Christie, Jane E. Visvader, François Vaillant
Publikováno v:
Cancer Cell. 24:120-129
SummaryThe prosurvival protein BCL-2 is frequently overexpressed in estrogen receptor (ER)-positive breast cancer. We have generated ER-positive primary breast tumor xenografts that recapitulate the primary tumors and demonstrate that the BH3 mimetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bf7a66d6d04482b1ca03d2522f9d09
https://doi.org/10.1016/j.ccr.2013.06.002
https://doi.org/10.1016/j.ccr.2013.06.002
Autor:
Persephone Borrow, Clare Thompson, Louisa J. Phillipson, Elizabeth Taylor, Helen M. I. Osborn, Catherine Thompson, Eriko Yamada, Wendy S. Barclay, Maria Zambon, Rachel E. Owen
Natural killer (NK) cell recognition of influenza virus-infected cells involves hemagglutinin (HA) binding to sialic acid (SA) on activating NK receptors. SA also acts as a receptor for the binding of influenza virus to its target host cells. The SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5b12c9030f1d8cf410794aa52725aa
https://europepmc.org/articles/PMC2045558/
https://europepmc.org/articles/PMC2045558/
Autor:
Wendy S. Barclay, Helen M. I. Osborn, Guadalupe A. Talevera, Junyuan Ren, Ian M. Jones, Catherine Thompson, Louisa J. Phillipson
Publikováno v:
Bioorganicmedicinal chemistry. 15(12)
Influenza viruses attach to host cells by binding to terminal sialic acid (Neu5Ac) on glycoproteins or glycolipids. Both the linkage of Neu5Ac and the identity of other carbohydrates within the oligosaccharide are thought to play roles in restricting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739cd1daf2ad6832d0a50aa03a4f3eb5
https://pubmed.ncbi.nlm.nih.gov/17451959
https://pubmed.ncbi.nlm.nih.gov/17451959