Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Louisa Helms"'
Autor:
Sienna R. Li, Ramila E. Gulieva, Louisa Helms, Nelly M. Cruz, Thomas Vincent, Hongxia Fu, Jonathan Himmelfarb, Benjamin S. Freedman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
In polycystic kidney disease (PKD), fluid-filled cysts arise from tubules. Here the authors show that subjecting organoids to fluid shear stress in a PKD-on-a-chip microphysiological system promotes cyst expansion via an absorptive pathway.
Externí odkaz:
https://doaj.org/article/c46ae4379a784182858157d336548bc7
Autor:
Louisa Helms, Silvia Marchiano, Ian B. Stanaway, Tien-Ying Hsiang, Benjamin A. Juliar, Shally Saini, Yan Ting Zhao, Akshita Khanna, Rajasree Menon, Fadhl Alakwaa, Carmen Mikacenic, Eric D. Morrell, Mark M. Wurfel, Matthias Kretzler, Jennifer L. Harder, Charles E. Murry, Jonathan Himmelfarb, Hannele Ruohola-Baker, Pavan K. Bhatraju, Michael Gale Jr., Benjamin S. Freedman
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
Kidneys are critical target organs of COVID-19, but susceptibility and responses to infection remain poorly understood. Here, we combine SARS-CoV-2 variants with genome-edited kidney organoids and clinical data to investigate tropism, mechanism, and
Externí odkaz:
https://doaj.org/article/f1245ff7051b4c249e2410817e4f3c9e
Autor:
Molly OhAinle, Louisa Helms, Jolien Vermeire, Ferdinand Roesch, Daryl Humes, Ryan Basom, Jeffrey J Delrow, Julie Overbaugh, Michael Emerman
Publikováno v:
eLife, Vol 7 (2018)
Interferon (IFN) inhibits HIV replication by inducing antiviral effectors. To comprehensively identify IFN-induced HIV restriction factors, we assembled a CRISPR sgRNA library of Interferon Stimulated Genes (ISGs) into a modified lentiviral vector th
Externí odkaz:
https://doaj.org/article/d00363c9c13a413a99b3da1064c12277
Autor:
Andrew C. Hunt, James Brett Case, Young-Jun Park, Longxing Cao, Kejia Wu, Alexandra C. Walls, Zhuoming Liu, John E. Bowen, Hsien-Wei Yeh, Shally Saini, Louisa Helms, Yan Ting Zhao, Tien-Ying Hsiang, Tyler N. Starr, Inna Goreshnik, Lisa Kozodoy, Lauren Carter, Rashmi Ravichandran, Lydia B. Green, Wadim L. Matochko, Christy A. Thomson, Bastian Vögeli, Antje Krüger, Laura A. VanBlargan, Rita E. Chen, Baoling Ying, Adam L. Bailey, Natasha M. Kafai, Scott E. Boyken, Ajasja Ljubetič, Natasha Edman, George Ueda, Cameron M. Chow, Max Johnson, Amin Addetia, Mary-Jane Navarro, Nuttada Panpradist, Michael Gale, Benjamin S. Freedman, Jesse D. Bloom, Hannele Ruohola-Baker, Sean P. J. Whelan, Lance Stewart, Michael S. Diamond, David Veesler, Michael C. Jewett, David Baker
Publikováno v:
SCIENCE TRANSLATIONAL MEDICINE
Science translational medicine, vol 14, iss 646
Science translational medicine, vol 14, iss 646
New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here, we used a cell-free expression workflow to rapidly screen and optimize constructs conta
Autor:
Eric D. Morrell, Pavan K. Bhatraju, Matthias Kretzler, Fadhl M. Al-Akwaa, Shally Saini, Hannele Ruohola-Baker, Louisa Helms, Benjamin S. Freedman, Rajasree Menon, Mark M. Wurfel, Silvia Marchianò, Michael Gale, Yan Ting Zhao, Benjamin A Juliar, Jonathan Himmelfarb, Carmen Mikacenic, Akshita Khanna, Tien-Ying Hsiang, Ian B. Stanaway, Charles E. Murry, Jennifer L. Harder
Publikováno v:
JCI Insight
Kidneys are critical target organs of COVID-19, but susceptibility and responses to infection remain poorly understood. Here, we combine SARS-CoV-2 variants with genome edited kidney organoids and clinical data to investigate tropism, mechanism, and
Autor:
David Veesler, James Brett Case, Sean P. J. Whelan, Benjamin S. Freedman, Hsien-Wei Yeh, Ajasja Ljubetič, Hannele Ruohola-Baker, Barry R. Lutz, Louisa Helms, Bastain Vogeli, Yan Ting Zhao, Laura A. VanBlargan, Baoling Ying, David Baker, Natasha I. Edman, Jesse D. Bloom, Natasha M. Kafai, Antje Kruger-gericke, Lauren Carter, Adam L. Bailey, Cameron M. Chow, John E. Bowen, George Ueda, Shally Saini, Amin Addetia, Inna Goreshnik, Michael Gale, Longxing Cao, Scott E. Boyken, Rita E. Chen, Andrew Hunt, Lisa Kozodoy, Kejia Wu, Michael S. Diamond, Wadim L. Matochko, Tien-Ying Hsiang, Michael C. Jewett, Young-Jun Park, Alexandra C. Walls, Lance Stewart, Rashmi Ravichandran, Zhuoming Liu, Christy Ann Thomson, Tyler N. Starr, Nuttada Panpradist, Lydia Green
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Escape variants of SARS-CoV-2 are threatening to prolong the COVID-19 pandemic. To address this challenge, we developed multivalent protein-based minibinders as potential prophylactic and therapeutic agents. Homotrimers of single minibinders and fusi
Autor:
Jeffrey J. Delrow, Ryan Basom, Louisa Helms, Jolien Vermeire, Ferdinand Roesch, Julie Overbaugh, Molly OhAinle, Michael Emerman, Daryl Humes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acf7e094ff315651af1ace8bda5985d5
https://doi.org/10.7554/elife.39823.034
https://doi.org/10.7554/elife.39823.034