Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Louis-David Cantin"'
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 77:94-99
MISER chromatography was evaluated to increase data processing speed for a rapid, miniaturized in vitro formulation screen. This approach permitted quick data interpretation by eliminating time-consuming steps such as integration, quantitation and re
Autor:
Valérie Campagna-Slater, Louis-David Cantin, Eric Therrien, Nicolas Moitessier, Joshua Pottel
Publikováno v:
Journal of Chemical Information and Modeling. 52:2471-2483
The metabolism of xenobiotics--and more specifically drugs--in the liver is a critical process controlling their half-life. Although there exist experimental methods, which measure the metabolic stability of xenobiotics and identify their metabolites
Autor:
Jeffrey Shapiro, Bullock William H, Christine Keiper, Manami Tsutsumi, Ling Yang, Roger B Clark, Xin Ma, Sidney X. Liang, James N. Livingston, Louis-David Cantin, Christiana Iwuagwu, Frederick Ehrgott, Jeffrey Johnson, Thomas H. Claus, Ken Boakye, Herbert Ogutu, Christopher Town, Michael Burns, Michelle Daly, Robert Schoenleber, Fernando E. delaCruz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1056-1061
Modulation of PPAR activities represents an attractive approach for the treatment of diabetes with associated cardiovascular complications. The indanylacetic acid structural motif has proven useful in the generation of potent and tunable PPAR ligands
Autor:
Hironori Harada, Ralph Hirschmann, Louis-David Cantin, Craig S. Kenesky, Amos B. Smith, Mark Stahlhut, David B. Olsen, William A. Schleif, Sanjeev Munshi, Lawrence C. Kuo, Adam Kenneth Charnley, Jason J. Beiger
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:859-863
A series of monopyrrolinone-based HIV-1 protease inhibitors possessing rationally designed P2' side chains have been synthesized and evaluated for activity against wild-type HIV-1 protease. The most potent inhibitor displays subnanomolar potency in v
Autor:
Paul A. Sprengeler, Alexander Pasternak, Lawrence C. Kuo, Ralph Hirschmann, Louis-David Cantin, Sanjeev Munshi, William A. Schleif, David B. Olsen, Adam Kenneth Charnley, Wenquin Yao, Amos B. Smith, Lisa Guise-Zawacki, J. Barbosa
Publikováno v:
Journal of Medicinal Chemistry. 46:1831-1844
The design, synthesis, and biological evaluation of a series of HIV-1 protease inhibitors [(-)-6, (-)-7, (-)-23, (+)-24] based upon the 3,5,5-trisubstituted pyrrolin-4-one scaffold is described. Use of a monopyrrolinone scaffold leads to inhibitors w
Publikováno v:
Tetrahedron. 57:6885-6900
The synthesis of cis- and trans-aziridine hydroxamic acid derivatives as MMP inhibitors is described using enantio- and diastereoselective methods for the formation of trisubstituted aziridines. Their preliminary inhibitory activity is reported and d
Autor:
Chicchi G, Smith Ab rd, Rohrer Sp, Josephine Liu, Underwood Dj, Ralph Hirschmann, Louis-David Cantin, Cascieri Ma
Publikováno v:
Journal of Medicinal Chemistry. 43:3827-3831
Autor:
Louis-David Cantin, Stephen Hanessian
Publikováno v:
Tetrahedron Letters. 41:787-790
The addition of a chloroallyl phosphonamide anion to oximes has allowed the preparation of a variety of cis-disubstituted N-alkoxy aziridines in enantiomerically pure form. Oxidative cleavage of the chiral auxiliary followed by derivatization of the
Publikováno v:
Chirality. 12:342-345
Anions of 1-halo-4-hexenyl phosphonamides derived from chiral, enantiopure C2 symmetrical 1,2-diamino cyclohexane react at the γ-position in conjugate addition reactions with α,β-unsaturated carbonyl compounds such as cyclopentenone, 4-(H)-furanon
Publikováno v:
The Journal of Organic Chemistry. 64:4893-4900
We report the total synthesis of the cytotoxic agent (-)-anthoplalone and the determination of its absolute stereochemistry. The cyclopropane moiety was prepared using a nonracemic bicyclic chloroallyl phosphonamide anion addition to tert-butyl 3,3-d